Search Results - "Chao, M V"

Neurotrophins and their receptors: A convergence point for many signalling pathways by Chao, Moses V

“…The neurotrophins are a family of proteins that are essential for the development of the vertebrate nervous system. Each neurotrophin can signal through two…”
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Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1 by Kim, Albert H., Khursigara, Gus, Sun, Xuan, Franke, Thomas F., Chao, Moses V.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75 by Casaccia-Bonnefil, Patrizia, Carter, Bruce D, Dobrowsky, Rick T, Chao, Moses V

“…Members of the nerve growth factor (NGF) family promote the survival of neurons during development. NGF specifically activates the receptor trkA, initiating a…”
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Cleavage of p75 neurotrophin receptor is linked to Alzheimer’s disease by Chao, M V

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Are BDNF and glucocorticoid activities calibrated? by Jeanneteau, F, Chao, M.V

“…Graphical abstract The schematic is modified from Martin and Finsterwald (Commun Integr Biol. 4, 14–16, 2011). Highlights • Glucocorticoid oscillations enhance…”
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Neurotrophin receptors: a window into neuronal differentiation by Chao, M V

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Brain-Specific Deletion of Neuropathy Target Esterase/swisscheese Results in Neurodegeneration by Akassoglou, Katerina, Malester, Brian, Xu, Jixiang, Tessarollo, Lino, Rosenbluth, Jack, Chao, Moses V., Reese, Thomas S.

“…Neuropathy target esterase (NTE) is a neuronal membrane protein originally identified for its property to be modified by organophosphates (OPs), which in…”
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Differential Expression of Nerve Growth Factor Receptors Leads to Altered Binding Affinity and Neurotrophin Responsiveness by Benedetti, Marta, Levi, Andrea, Chao, Moses V.

“…The low-affinity p75 neurotrophin receptor is believed to participate with the Trk receptor tyrosine kinase in the formation of high-affinity binding sites for…”
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GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways by Lou, X, Yano, H, Lee, F, Chao, M V, Farquhar, M G

“…NGF initiates the majority of its neurotrophic effects by promoting the activation of the tyrosine kinase receptor TrkA. Here we describe a novel interaction…”
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Association of Trk Neurotrophin Receptors with Components of the Cytoplasmic Dynein Motor by Yano, Hiroko, Lee, Francis S, Kong, Haeyoung, Chuang, Jen-Zen, Arevalo, Juan Carlos, Perez, Pilar, Sung, Ching-Hwa, Chao, Moses V

“…Nerve growth factor (NGF) initiates its trophic effects by long-range signaling through binding, internalization, and transport of a ligand-receptor complex…”
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The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus by Ninan, Ipe, Bath, Kevin G, Dagar, Karishma, Perez-Castro, Rosalia, Plummer, Mark R, Lee, Francis S, Chao, Moses V

“…The Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene results in a defect in regulated release of BDNF and affects episodic memory and…”
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Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor by Dobrowsky, Rick T., Werner, Mark H., Castellino, Alexander M., Chao, Moses V., Hannun, Yusuf A.

“…The role of the low-affinity neurotrophin receptor (p75$^{NTR}$) in signal transduction is undefined. Nerve growth factor can activate the sphingomyelin cycle,…”
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Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation by Casaccia-Bonnefil, P, Hardy, R J, Teng, K K, Levine, J M, Koff, A, Chao, M V

“…In many tissues, progenitor cells permanently withdraw from the cell cycle prior to commitment towards a differentiated phenotype. In the oligodendrocyte…”
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K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity by Berg, M M, Sternberg, D W, Parada, L F, Chao, M V

“…The rat pheochromocytoma PC12 cell line differentiates into a sympathetic neuronal phenotype upon treatment with either nerve growth factor (NGF) or basic…”
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Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system by Lee, K F, Li, E, Huber, L J, Landis, S C, Sharpe, A H, Chao, M V, Jaenisch, R

“…We have generated mice carrying a mutation of the gene encoding the low affinity NGF receptor p75NGFR by targeted mutation in embryonic stem cells. Mice…”
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Mechanisms of neurotrophin receptor signalling by Zampieri, N, Chao, M V

“…Regulation of cell survival decisions and neuronal plasticity by neurotrophins are mediated by two classes of receptors, Trks (tropomyosin receptor kinases)…”
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Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death by Casaccia-Bonnefil, P., Aibel, L., Chao, M. V.

“…Ceramide is a lipid second messenger implicated in the mechanism of apoptotic cell death. The effect of the cell‐permeable ceramide analogue C2 has been tested…”
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Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts: implications for neuromodulation by Assaife-Lopes, Natália, Sousa, Vasco C, Pereira, Daniela B, Ribeiro, Joaquim A, Chao, Moses V, Sebastião, Ana M

“…Brain-derived neurotrophic factor (BDNF) signaling is critical for neuronal development and transmission. Recruitment of TrkB receptors to lipid rafts has been…”
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Disruption of cysteine-rich repeats of the p75 nerve growth factor receptor leads to loss of ligand binding by Yan, H, Chao, M V

“…Nerve growth factor (NGF) binds to a low affinity cell surface receptor (p75NGFR) which contains four extracellular repeats, rich in cysteine residues and…”
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The Low-Affinity p75 Nerve Growth Factor (NGF) Receptor Mediates NGF- Induced Tyrosine Phosphorylation by Berg, Margaret M., Sternberg, David W., Hempstead, Barbara L., Chao, Moses V.

“…Protein tyrosine phosphorylation is a potential mechanism for initial signaling in PC12 cells during differentiation in response to nerve growth factor (NGF)…”
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