SNARE protein regulation of cardiac potassium channels and atrial natriuretic factor secretion

Abstract Coordinated cardiac ion channel gating is fundamental for generation of action potential and excitability throughout the myocardium. The interaction of pore-forming ion channels with auxiliary subunits can regulate surface expression, localization and anchoring of these channels to plasma m...

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Bibliographic Details
Published in:	Journal of molecular and cellular cardiology Vol. 50; no. 3; pp. 401 - 407
Main Authors:	Chao, Christin C.T, Mihic, Anton, Tsushima, Robert G, Gaisano, Herbert Y
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-03-2011
Subjects:	Animals ATP-sensitive potassium channel Atrial Natriuretic Factor - metabolism Cardiovascular Heart - physiology Humans Myocardium - metabolism Potassium Channels - metabolism SNAP-25 SNARE SNARE Proteins - metabolism Syntaxin-1A Voltage-gated potassium channel voltage-gated potassium voltage-gated calcium BNP brain natriuretic peptide ATP-sensitive potassium ATP-sensitive potassium channel adenylate kinase NBF K ATP sulphonylurea receptor pentraxin-like NSF VAMP Syn AK human ether-à-go-go-related gene PTTX SNAP receptor SUR dipeptidyl peptidase Kir ATP-binding cassette ANF ATP-sensitive potassium channel opener CFTR K V ABC CNP DPP Ca v Voltage-gated potassium channel SNARE cystic fibrosis transmembrane regulator inward-rectifier potassium transmembrane domain atrial natriuretic factor creatine kinase K ATPCO SNAP-25 hERG NSF attachment protein CK TMD SNAP nucleotide-binding fold vesicle-associated membrane protein syntaxin c-type natriuretic peptide Syntaxin-1A soluble N-ethylmaleimide sensitive factor KATPCO KV KATP Cav
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Summary:	Abstract Coordinated cardiac ion channel gating is fundamental for generation of action potential and excitability throughout the myocardium. The interaction of pore-forming ion channels with auxiliary subunits can regulate surface expression, localization and anchoring of these channels to plasma membrane. SNARE ( s oluble N -ethylmaleimide sensitive factors a ttachment p rotein or SNAP receptor) proteins mediate the targeting, docking, and fusion of intracellular vesicles for exocytotic release of neurotransmitters and hormones. In secretory neurons and neuroendocrine cells, some voltage-gated channels are physically coupled with SNARE proteins, resulting in alterations in channel gating and trafficking. Coupling of SNARE proteins to membrane ion channels is however not unique to secretory cells. We have demonstrated the expression of SNARE proteins in rodent myocardial tissue, and more importantly, functional interaction of SNARE proteins with cardiac KATP and Kv (Kv 1.2, Kv 2.1, Kv 4.2, Kv 4.3, and Kv 11.1) channels. SNARE proteins, therefore, have similar fundamental functions in ion channel trafficking and regulation per se , independent of secretion. We now review the body of work of SNARE protein regulation on membrane ion channels in the heart.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0022-2828 1095-8584
DOI:	10.1016/j.yjmcc.2010.11.018