Search Results - "Chanock, Stephen J"

LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants by Machiela, Mitchell J, Chanock, Stephen J

“…Assessing linkage disequilibrium (LD) across ancestral populations is a powerful approach for investigating population-specific genetic structure as well as…”
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LDassoc: an online tool for interactively exploring genome-wide association study results and prioritizing variants for functional investigation by Machiela, Mitchell J, Chanock, Stephen J

“…Abstract Motivation Existing approaches to plot association results from genome-wide association studies (GWAS) are in the form of static Manhattan plots and…”
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LDlinkR : An R Package for Rapidly Calculating Linkage Disequilibrium Statistics in Diverse Populations by Myers, Timothy A, Chanock, Stephen J, Machiela, Mitchell J

“…Genomic research involving human genetics and evolutionary biology relies heavily on linkage disequilibrium (LD) to investigate population-specific genetic…”
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Estimation of effect size distribution from genome-wide association studies and implications for future discoveries by Chatterjee, Nilanjan, Park, Ju-Hyun, Wacholder, Sholom, Gail, Mitchell H, Peters, Ulrike, Jacobs, Kevin B, Chanock, Stephen J

“…Nilanjan Chatterjee and colleagues report an analysis of the number and effect size distribution of susceptibility variants identified from current genome-wide…”
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Burden of Nonsynonymous Mutations among TCGA Cancers and Candidate Immune Checkpoint Inhibitor Responses by Colli, Leandro M, Machiela, Mitchell J, Myers, Timothy A, Jessop, Lea, Yu, Kai, Chanock, Stephen J

“…Immune checkpoint inhibitor treatment represents a promising approach toward treating cancer and has been shown to be effective in a subset of melanoma,…”
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Powerful SNP-Set Analysis for Case-Control Genome-wide Association Studies by Wu, Michael C., Kraft, Peter, Epstein, Michael P., Taylor, Deanne M., Chanock, Stephen J., Hunter, David J., Lin, Xihong

“…GWAS have emerged as popular tools for identifying genetic variants that are associated with disease risk. Standard analysis of a case-control GWAS involves…”
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A Subset-Based Approach Improves Power and Interpretation for the Combined Analysis of Genetic Association Studies of Heterogeneous Traits by Bhattacharjee, Samsiddhi, Rajaraman, Preetha, Jacobs, Kevin B., Wheeler, William A., Melin, Beatrice S., Hartge, Patricia, Yeager, Meredith, Chung, Charles C., Chanock, Stephen J., Chatterjee, Nilanjan

“…Pooling genome-wide association studies (GWASs) increases power but also poses methodological challenges because studies are often heterogeneous. For example,…”
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Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma by Shi, Jianxin, Yang, Xiaohong R, Ballew, Bari, Rotunno, Melissa, Calista, Donato, Fargnoli, Maria Concetta, Ghiorzo, Paola, Bressac-de Paillerets, Brigitte, Nagore, Eduardo, Avril, Marie Francoise, Caporaso, Neil E, McMaster, Mary L, Cullen, Michael, Wang, Zhaoming, Zhang, Xijun, Bruno, William, Pastorino, Lorenza, Queirolo, Paola, Banuls-Roca, Jose, Garcia-Casado, Zaida, Vaysse, Amaury, Mohamdi, Hamida, Riazalhosseini, Yasser, Foglio, Mario, Jouenne, Fanélie, Hua, Xing, Hyland, Paula L, Yin, Jinhu, Vallabhaneni, Haritha, Chai, Weihang, Minghetti, Paola, Pellegrini, Cristina, Ravichandran, Sarangan, Eggermont, Alexander, Lathrop, Mark, Peris, Ketty, Scarra, Giovanna Bianchi, Landi, Giorgio, Savage, Sharon A, Sampson, Joshua N, He, Ji, Yeager, Meredith, Goldin, Lynn R, Demenais, Florence, Chanock, Stephen J, Tucker, Margaret A, Goldstein, Alisa M, Liu, Yie, Landi, Maria Teresa

“…Maria Teresa Landi and colleagues identify a rare missense variant in POT1 shared by five melanoma-prone families from Italy and associated with increased…”
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Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery by Hu, Yue, Gaedcke, Jochen, Emons, Georg, Beissbarth, Tim, Grade, Marian, Jo, Peter, Yeager, Meredith, Chanock, Stephen J., Wolff, Hendrik, Camps, Jordi, Ghadimi, B. Michael, Ried, Thomas

“…To understand the molecular mechanism of rectal cancer and develop markers for disease prognostication, we generated and explored a dataset from 243 rectal…”
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Detectable clonal mosaicism from birth to old age and its relationship to cancer by Laurie, Cathy C, Laurie, Cecelia A, Rice, Kenneth, Doheny, Kimberly F, Zelnick, Leila R, McHugh, Caitlin P, Ling, Hua, Hetrick, Kurt N, Pugh, Elizabeth W, Amos, Chris, Wei, Qingyi, Wang, Li-e, Lee, Jeffrey E, Barnes, Kathleen C, Hansel, Nadia N, Mathias, Rasika, Daley, Denise, Beaty, Terri H, Scott, Alan F, Ruczinski, Ingo, Scharpf, Rob B, Bierut, Laura J, Hartz, Sarah M, Landi, Maria Teresa, Freedman, Neal D, Goldin, Lynn R, Ginsburg, David, Li, Jun, Desch, Karl C, Strom, Sara S, Blot, William J, Signorello, Lisa B, Ingles, Sue A, Chanock, Stephen J, Berndt, Sonja I, Le Marchand, Loic, Henderson, Brian E, Monroe, Kristine R, Heit, John A, de Andrade, Mariza, Armasu, Sebastian M, Regnier, Cynthia, Lowe, William L, Hayes, M Geoffrey, Marazita, Mary L, Feingold, Eleanor, Murray, Jeffrey C, Melbye, Mads, Feenstra, Bjarke, Kang, Jae H, Wiggs, Janey L, Jarvik, Gail P, McDavid, Andrew N, Seshan, Venkatraman E, Mirel, Daniel B, Crenshaw, Andrew, Sharopova, Nataliya, Wise, Anastasia, Shen, Jess, Crosslin, David R, Levine, David M, Zheng, Xiuwen, Udren, Jenna I, Bennett, Siiri, Nelson, Sarah C, Gogarten, Stephanie M, Conomos, Matthew P, Heagerty, Patrick, Manolio, Teri, Pasquale, Louis R, Haiman, Christopher A, Caporaso, Neil, Weir, Bruce S

“…Cathy Laurie and colleagues detect mosaicism for large chromosomal abnormalities in peripheral blood in a subset of healthy individuals. They show that the…”
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GWASdb: a database for human genetic variants identified by genome-wide association studies by Li, Mulin Jun, Wang, Panwen, Liu, Xiaorong, Lim, Ee Lyn, Wang, Zhangyong, Yeager, Meredith, Wong, Maria P., Sham, Pak Chung, Chanock, Stephen J., Wang, Junwen

“…Recent advances in genome-wide association studies (GWAS) have enabled us to identify thousands of genetic variants (GVs) that are associated with human…”
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Distribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants by Park, Ju-Hyun, Gail, Mitchell H, Weinberg, Clarice R, Carroll, Raymond J, Chung, Charles C, Wang, Zhaoming, Chanock, Stephen J, Fraumeni, Joseph F. Jr, Chatterjee, Nilanjan

“…Recent discoveries of hundreds of common susceptibility SNPs from genome-wide association studies provide a unique opportunity to examine population genetic…”
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Population structure of human gut bacteria in a diverse cohort from rural Tanzania and Botswana by Hansen, Matthew E B, Rubel, Meagan A, Bailey, Aubrey G, Ranciaro, Alessia, Thompson, Simon R, Campbell, Michael C, Beggs, William, Dave, Jaanki R, Mokone, Gaonyadiwe G, Mpoloka, Sununguko Wata, Nyambo, Thomas, Abnet, Christian, Chanock, Stephen J, Bushman, Frederic D, Tishkoff, Sarah A

“…Gut microbiota from individuals in rural, non-industrialized societies differ from those in individuals from industrialized societies. Here, we use 16S rRNA…”
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Interpretable, non-mechanistic forecasting using empirical dynamic modeling and interactive visualization by Mason, Lee, Berrington de Gonzalez, Amy, Garcia-Closas, Montserrat, Chanock, Stephen J, Hicks, Blànaid, Almeida, Jonas S

“…Forecasting methods are notoriously difficult to interpret, particularly when the relationship between the data and the resulting forecasts is not obvious…”
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The case for increasing diversity in tissue-based functional genomics datasets to understand human disease susceptibility by Long, Erping, García-Closas, Montserrat, Chanock, Stephen J., Camargo, M. Constanza, Banovich, Nicholas E., Choi, Jiyeon

“…Tissue-based functional genomics resources including molecular quantitative trait loci datasets lack diversity in ancestry and tissue types and thus are…”
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Genetically predicted telomere length is associated with clonal somatic copy number alterations in peripheral leukocytes by Brown, Derek W, Lin, Shu-Hong, Loh, Po-Ru, Chanock, Stephen J, Savage, Sharon A, Machiela, Mitchell J

“…Telomeres are DNA-protein structures at the ends of chromosomes essential in maintaining chromosomal stability. Observational studies have identified…”
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Circulating adipokine concentrations and risk of five obesity‐related cancers: A Mendelian randomization study by Dimou, Niki L., Papadimitriou, Nikos, Mariosa, Daniela, Johansson, Mattias, Brennan, Paul, Peters, Ulrike, Chanock, Stephen J., Purdue, Mark, Bishop, D. Timothy, Gago‐Dominquez, Manuela, Giles, Graham G., Moreno, Victor, Platz, Elizabeth A., Tangen, Catherine M., Wolk, Alicja, Zheng, Wei, Wu, Xifeng, Campbell, Peter T., Giovannucci, Edward, Lin, Yi, Gunter, Marc J., Murphy, Neil

“…Obesity is considered a chronic inflammatory state characterized by continued secretion of adipokines and cytokines. Experimental and epidemiological evidence…”
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Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men by Lin, Shu-Hong, Loftfield, Erikka, Sampson, Josh N., Zhou, Weiyin, Yeager, Meredith, Freedman, Neal D., Chanock, Stephen J., Machiela, Mitchell J.

“…Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number alteration in leukocytes of men. In this study, we investigate blood…”
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Constitutional telomerase mutations are genetic risk factors for cirrhosis by Calado, Rodrigo T., Brudno, Jennifer, Mehta, Paulomi, Kovacs, Joseph J., Wu, Colin, Zago, Marco A., Chanock, Stephen J., Boyer, Thomas D., Young, Neal S.

“…Some patients with liver disease progress to cirrhosis, but the risk factors for cirrhosis development are unknown. Dyskeratosis congenita, an inherited bone…”
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C-Reactive Protein and Risk of Lung Cancer by CHATURVEDI, Anil K, CAPORASO, Neil E, KATKI, Hormuzd A, WONG, Hui-Lee, CHATTERJEE, Nilanjan, PINE, Sharon R, CHANOCK, Stephen J, GOEDERT, James J, ENGELS, Eric A

“…Chronic inflammation could play a role in lung carcinogenesis, underscoring the potential for lung cancer prevention and screening. We investigated the…”
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