Search Results - "Changiz Geula"

Primary progressive aphasia and the evolving neurology of the language network by Mesulam, M.-Marsel, Rogalski, Emily J., Wieneke, Christina, Hurley, Robert S., Geula, Changiz, Bigio, Eileen H., Thompson, Cynthia K., Weintraub, Sandra

“…Key Points Primary progressive aphasia (PPA) is a clinical syndrome caused by selective neurodegeneration of the language-dominant cerebral hemisphere, thus…”
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Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance by Geula, Changiz, Dunlop, Sara R., Ayala, Ivan, Kawles, Allegra S., Flanagan, Margaret E., Gefen, Tamar, Mesulam, Marek‐Marsel

“…The basal forebrain cholinergic neurons (BFCN) provide the primary source of cholinergic innervation of the human cerebral cortex. They are involved in the…”
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Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway by Jiang, Shanya, Maphis, Nicole M., Binder, Jessica, Chisholm, Devon, Weston, Lea, Duran, Walter, Peterson, Crina, Zimmerman, Amber, Mandell, Michael A., Jett, Stephen D., Bigio, Eileen, Geula, Changiz, Mellios, Nikolaos, Weick, Jason P., Rosenberg, Gary A., Latz, Eicke, Heneka, Michael T., Bhaskar, Kiran

“…Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of…”
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Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons by Khrapko, Konstantin, Kraytsberg, Yevgenya, Kudryavtseva, Elena, McKee, Ann C, Geula, Changiz, Kowall, Neil W

“…Using a novel single-molecule PCR approach to quantify the total burden of mitochondrial DNA (mtDNA) molecules with deletions, we show that a high proportion…”
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Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project by Rogalski, Emily J, Gefen, Tamar, Shi, Junzi, Samimi, Mehrnoosh, Bigio, Eileen, Weintraub, Sandra, Geula, Changiz, Mesulam, M-Marsel

“…The Northwestern University SuperAging Project recruits community dwellers over the age of 80 who have unusually high performance on tests of episodic memory…”
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Nosology of Primary Progressive Aphasia and the Neuropathology of Language by Mesulam, M -Marsel, Coventry, Christina, Bigio, Eileen H, Geula, Changiz, Thompson, Cynthia, Bonakdarpour, Borna, Gefen, Tamar, Rogalski, Emily J, Weintraub, Sandra

“…Primary progressive aphasia (PPA) is a dementia syndrome associated with several neuropathologic entities, including Alzheimer's disease (AD) and all major…”
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Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS by Genç, Barış, Jara, Javier H., Lagrimas, Amiko K. B., Pytel, Peter, Roos, Raymond P., Mesulam, M. Marsel, Geula, Changiz, Bigio, Eileen H., Özdinler, P. Hande

“…Apical dendrites of Betz cells are important sites for the integration of cortical input, however their health has not been fully assessed in ALS patients. We…”
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Cortical and subcortical pathological burden and neuronal loss in an autopsy series of FTLD-TDP-type C by Kawles, Allegra, Nishihira, Yasushi, Feldman, Alex, Gill, Nathan, Minogue, Grace, Keszycki, Rachel, Coventry, Christina, Spencer, Callen, Lilek, Jaclyn, Ajroud, Kaouther, Coppola, Giovanni, Rademakers, Rosa, Rogalski, Emily, Weintraub, Sandra, Zhang, Hui, Flanagan, Margaret E, Bigio, Eileen H, Mesulam, M-Marsel, Geula, Changiz, Mao, Qinwen, Gefen, Tamar

“…The TDP-43 type C pathological form of frontotemporal lobar degeneration is characterized by the presence of immunoreactive TDP-43 short and long dystrophic…”
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Dendritic spinule-mediated structural synaptic plasticity: Implications for development, aging, and psychiatric disease by Zaccard, Colleen R, Gippo, Isabel, Song, Amy, Geula, Changiz, Penzes, Peter

“…Dendritic spines are highly dynamic and changes in their density, size, and shape underlie structural synaptic plasticity in cognition and memory. Fine…”
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Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging by Paudel, Bidur, Jeong, Si-Yeon, Martinez, Carolina Pena, Rickman, Alexis, Haluck-Kangas, Ashley, Bartom, Elizabeth T., Fredriksen, Kristina, Affaneh, Amira, Kessler, John A., Mazzulli, Joseph R., Murmann, Andrea E., Rogalski, Emily, Geula, Changiz, Ferreira, Adriana, Heckmann, Bradlee L., Green, Douglas R., Sadleir, Katherine R., Vassar, Robert, Peter, Marcus E.

“…Alzheimer’s disease (AD) is characterized by progressive neurodegeneration, but the specific events that cause cell death remain poorly understood. Death…”
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Cholinergic Neuronal and Axonal Abnormalities Are Present Early in Aging and in Alzheimer Disease by Geula, Changiz, Nagykery, Nicholas, Nicholas, Alexander, Wu, Chuang-Kuo

“…A large body of evidence indicates that basal forebrain cholinergic neurons are selectively vulnerable to degeneration early in Alzheimer disease (AD). Recent…”
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Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes by Nishihira, Yasushi, Gefen, Tamar, Mao, Qinwen, Appin, Christina, Kohler, Missia, Walker, Jamie, Rademakers, Rosa, Rademaker, Alfred, Rogalski, Emily, Weintraub, Sandra, Geula, Changiz, Mesulam, M-Marsel, Bigio, Eileen H.

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Morphology and Distribution of TDP-43 Pre-inclusions in Primary Progressive Aphasia by Kim, Garam, Bolbolan, Kabriya, Shahidehpour, Ryan, Jamshidi, Pouya, Gefen, Tamar, Ayala, Ivan A, Weintraub, Sandra, Bigio, Eileen H, Mesulam, Marek-Marsel, Geula, Changiz

“…Abstract Diffusely stained phosphorylated 43-kDa TAR DNA-binding protein (TDP-43)-positive “pre-inclusions” have been described. This experiment investigated…”
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Distinct and shared neuropsychiatric phenotypes in FTLD-tauopathies by Keszycki, Rachel, Kawles, Allegra, Minogue, Grace, Zouridakis, Antonia, Macomber, Alyssa, Gill, Nathan, Vu, My, Zhang, Hui, Coventry, Christina, Rogalski, Emily, Weintraub, Sandra, Mesulam, M-Marsel, Geula, Changiz, Gefen, Tamar

“…Frontotemporal lobar degeneration (FTLD) with tau pathology (FTLD-tau) commonly causes dementia syndromes that include primary progressive aphasia (PPA) and…”
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Biochemical differentiation of cholinesterases from normal and Alzheimer's disease cortex by Ciro, Alexis, Park, Joon, Burkhard, Gary, Yan, Nicole, Geula, Changiz

“…In Alzheimer's disease, histochemically visualized cholinesterases with altered pH optimum for activity and inhibitable by indoleamines and the protease…”
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Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories by Gefen, Tamar, Kim, Garam, Bolbolan, Kabriya, Geoly, Andrew, Ohm, Daniel, Oboudiyat, Carly, Shahidehpour, Ryan, Rademaker, Alfred, Weintraub, Sandra, Bigio, Eileen H, Mesulam, M-Marsel, Rogalski, Emily, Geula, Changiz

“…Activation of microglia, the primary mediators of inflammation in the brain, is a major component of gliosis and neuronal loss in a number of age-related…”
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DJ-1 Transcriptionally Up-regulates the Human Tyrosine Hydroxylase by Inhibiting the Sumoylation of Pyrimidine Tract-binding Protein-associated Splicing Factor by Zhong, Nan, Kim, Christina Y., Rizzu, Patrizia, Geula, Changiz, Porter, Douglas R., Pothos, Emmanuel N., Squitieri, Ferdinando, Heutink, Peter, Xu, Jin

“…Loss-of-function mutations in DJ-1 cause a subset of familial Parkinson disease (PD). However, the mechanism underlying the selective vulnerability in…”
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A lifespan observation of a novel mouse model: in vivo evidence supports aβ oligomer hypothesis by Zhang, Yichi, Lu, Lu, Jia, Jianping, Jia, Longfei, Geula, Changiz, Pei, Jinjing, Xu, Zhiqing, Qin, Wei, Liu, Ruiqin, Li, Dan, Pan, Na

“…Transgenic mouse models are powerful tools in exploring the mechanisms of AD. Most current transgenic models of AD mimic the memory impairment and the main…”
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Alterations of Ca2+ -responsive proteins within cholinergic neurons in aging and Alzheimer's disease by Riascos, David, Nicholas, Alexander, Samaeekia, Ravand, Yukhananov, Rustam, Mesulam, M.-Marsel, Bigio, Eileen H, Weintraub, Sandra, Guo, Ling, Geula, Changiz

“…Abstract The molecular basis of selective neuronal vulnerability in Alzheimer's disease (AD) remains poorly understood. Using basal forebrain cholinergic…”
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Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology by Martersteck, Adam, Ayala, Ivan, Ohm, Daniel T, Spencer, Callen, Coventry, Christina, Weintraub, Sandra, Bigio, Eileen H, Mesulam, M -Marsel, Geula, Changiz, Rogalski, Emily

“…Quantification of in vivo amyloid and tau PET imaging relationships with postmortem measurements are critical for validating the sensitivity and specificity…”
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