Search Results - "Chang, Zhenzhan"
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Genome-Wide Identification and Functional Characterization of UDP-Glucosyltransferase Genes Involved in Flavonoid Biosynthesis in Glycine max
Published in Plant and cell physiology (01-09-2017)“…Flavonoids, natural products abundant in the model legume Glycine max, confer benefits to plants and to animal health. Flavonoids are present in soybean mainly…”
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2
Crystal structure of CYP76AH1 in 4-PI-bound state from Salvia miltiorrhiza
Published in Biochemical and biophysical research communications (16-04-2019)“…Tanshinones are important diterpenoid secondary metabolites from Salvia miltiorrhiza, widely used as cardiovascular and cerebrovascular medicines. CYP76AH1 is…”
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3
Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase
Published in Proceedings of the National Academy of Sciences - PNAS (16-09-2008)“…Cytochrome P450s exist ubiquitously in all organisms and are involved in many biological processes. Allene oxide synthase (AOS) is a P450 enzyme that plays a…”
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4
Genomic, transcriptomic, and epigenomic analysis of a medicinal snake, Bungarus multicinctus, to provides insights into the origin of Elapidae neurotoxins
Published in Acta pharmaceutica Sinica. B (01-05-2023)“…The many-banded krait, Bungarus multicinctus, has been recorded as the animal resource of JinQianBaiHuaShe in the Chinese Pharmacopoeia. Characterization of…”
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5
Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model
Published in Research (Washington) (2024)“…Although cytochrome P450 enzymes are the most versatile biocatalysts in nature, there is insufficient comprehension of the molecular mechanism underlying their…”
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Panax ginseng genome examination for ginsenoside biosynthesis
Published in Gigascience (01-11-2017)Get full text
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7
Crystal Structure of Isoflavone Reductase from Alfalfa ( Medicago sativa L.)
Published in Journal of molecular biology (19-05-2006)“…Isoflavonoids play important roles in plant defense and exhibit a range of mammalian health-promoting activities. Isoflavone reductase (IFR) specifically…”
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8
Chemical Cross-linking and Mass Spectrometric Identification of Sites of Interaction for UreD, UreF, and Urease
Published in The Journal of biological chemistry (09-04-2004)“…Synthesis of active Klebsiella aerogenes urease requires four accessory proteins to generate, in a GTP-dependent process, a dinuclear nickel active site with…”
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Involvement of three putative glucosyltransferases from the UGT72 family in flavonol glucoside/rhamnoside biosynthesis in Lotus japonicus seeds
Published in Journal of experimental botany (01-01-2017)“…Flavonols are one of the largest groups of flavonoids that confer benefits for the health of plants and animals. Flavonol glycosides are the predominant…”
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10
Crystal structure combined with metabolomics and biochemical studies indicates that FAM3A participates in fatty acid beta-oxidation upon binding of acyl-L-carnitine
Published in Biochemical and biophysical research communications (26-11-2024)“…As the first member of the family with sequence similarity 3 (FAM3), FAM3A promotes synthesis of ATP in mitochondria of hepatic cells and cells from other…”
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11
Unraveling the Catalytic Mechanism of Taxadiene-5α-hydroxylase from Crystallography and Computational Analyses
Published in ACS catalysis (15-03-2024)“…Paclitaxel is a famous chemotherapeutic agent, but its microbial production poses a long-standing challenge due to its poor product selectivity…”
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12
Structural insights revealed by crystal structures of CYP76AH1 and CYP76AH1 in complex with its natural substrate
Published in Biochemical and biophysical research communications (10-12-2021)“…CYP76AH1 is the key enzyme in the biosynthesis pathway of tanshinones in Salvia miltiorrhiza, which are famous natural products with activities against various…”
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13
Anthraquinones from hairy root cultures of Cassia obtusifolia
Published in Phytochemistry (Oxford) (20-11-1998)“…Hairy root cultures of Cassia obtusifolia clones transformed with Agrobacterium rhizogenes strain 9402 were established to investigate the anthraquinone…”
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14
Shotgun proteomic analysis of sarcoplasmic reticulum preparations from rabbit skeletal muscle
Published in Proteomics (Weinheim) (01-08-2013)“…To obtain a comprehensive understanding of proteins involved in excitation–contraction coupling, a catalog of proteins from sarcoplasmic reticulum (SR)…”
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15
Functional expression and purification of CYP93C20, a plant membrane-associated cytochrome P450 from Medicago truncatula
Published in Protein expression and purification (01-10-2018)“…Plants possess very large numbers of biosynthetic cytochrome P450 enzymes. In spite of the importance of these enzymes for the synthesis of bioactive plant…”
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16
The interactions between mitochondria and sarcoplasmic reticulum and the proteome characterization of mitochondrion-associated membrane from rabbit skeletal muscle
Published in Proteomics (Weinheim) (01-08-2015)“…To obtain a comprehensive understanding of proteins involved in mitochondrion‐sarcoplasmic reticulum (SR) linking, a catalog of proteins from…”
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17
Panax ginseng genome examination for ginsenoside biosynthesis
Published in Gigascience (01-11-2017)“…Ginseng, which contains ginsenosides as bioactive compounds, has been regarded as an important traditional medicine for several millennia. However, the genetic…”
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18
The Function of Ile-X-Ile Motif in the Oligomerization and Chaperone-Like Activity of Small Heat Shock Protein AgsA at Room Temperature
Published in Protein Journal (01-12-2016)“…Small heat shock proteins assemble as large oligomers in vitro and exhibit ATP-independent chaperone activities. Ile-X-Ile motif is essential in both the…”
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19
Functional Expression and Purification of CYP93C20,a Plant Membrane-Associated Cytochrome P450 from Medicago truncatula
Published in Protein expression and purification (04-12-2010)“…Plants possess very large numbers of biosynthetic cytochrome P450 enzymes. In spite of the importance of these enzymes for the synthesis of bioactive plant…”
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Crystallization and preliminary X-ray analysis of allene oxide synthase, cytochrome P450 CYP74A2, from Parthenium argentatum
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01-07-2008)“…Oxylipins are oxygenated derivatives of fatty acids and pivotal signaling molecules in plants and animals. Allene oxide synthase (AOS) is a key cytochrome P450…”
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