Changing Grains for the Prevention and Treatment of Kashin-Beck Disease in Children: a Meta-analysis

To evaluate the efficacy of changing grains on the prevention and treatment of Kashin-Beck Disease (KBD) in children, community-based trials were acquired from seven electronic databases (up to July 2014). As a result, the methodological quality of the six trials that have been included into our ana...

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Bibliographic Details
Published in:	Biomedical and environmental sciences Vol. 28; no. 4; p. 308
Main Authors:	Han, Jing, Yu, Fang Fang, Chang, Zai Ping, Yang, Bo, Qu, Cheng Juan, Zhou, Tian Tian, Liu, Rui Yu, Guo, Xiong
Format:	Journal Article
Language:	English
Published:	Netherlands 01-04-2015
Subjects:	Adolescent Child Child, Preschool Community-Based Participatory Research Edible Grain - physiology Humans Infant Infant, Newborn Kashin-Beck Disease - etiology Kashin-Beck Disease - prevention & control Kashin-Beck Disease - therapy
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Summary:	To evaluate the efficacy of changing grains on the prevention and treatment of Kashin-Beck Disease (KBD) in children, community-based trials were acquired from seven electronic databases (up to July 2014). As a result, the methodological quality of the six trials that have been included into our analysis was low. The pooled ORs favoring the prevention and treatment effects of changing grains were 0.15 (95% CI: 0.03-0.70) and 2.13 (95% CI: 1.44-3.16) respectively by meta-analysis. Subgroup analysis demonstrated the pooled OR favoring treatment effect of exchanging grains rather than drying grains both compared with endemic grains. The results showed that changing grains had obvious effects on the prevention and treatment of KBD in children. However, the evidences were limited by the potential biases and confounders. Large and well-designed trials are still needed.
ISSN:	0895-3988
DOI:	10.3967/bes2015.043