Search Results - "Chang, Zai"

Antimycobacterial Compound of Cynoglossum lanceolatum Forsk.: Bioassay Guided Isolation, Molecular Docking, Synthesis of Analogs, and a Plausible Mechanism of Action by Zhao, Xin, Wang, Lei, Xia, Meng‐Yu, Yang, Zai‐Chang

“…Tuberculosis (TB) remains a major threat to human health. Due to the prevalence of drug‐resistant Mycobacterium tuberculosis (Mtb), it is urgent to discover…”
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The landscape of accessible chromatin in mammalian preimplantation embryos by Wu, Jingyi, Huang, Bo, Chen, He, Yin, Qiangzong, Liu, Yang, Xiang, Yunlong, Zhang, Bingjie, Liu, Bofeng, Wang, Qiujun, Xia, Weikun, Li, Wenzhi, Li, Yuanyuan, Ma, Jing, Peng, Xu, Zheng, Hui, Ming, Jia, Zhang, Wenhao, Zhang, Jing, Tian, Geng, Xu, Feng, Chang, Zai, Na, Jie, Yang, Xuerui, Xie, Wei

“…In mammals, extensive chromatin reorganization is essential for reprogramming terminally committed gametes to a totipotent state during preimplantation…”
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Synthesis, antimycobacterial evaluation, and molecular docking study of 1,2,4-triazole derivatives by Xia, Meng-Yu, Cai, Yu-Xiang, Chen, Jun-Xian, Zhao, Xin, Dong, Hong-Mei, Yang, Zai-Chang

“…Fifteen 1,2,4-triazole derivatives were synthesised in this study and their MIC values against Mycobacterium tuberculosis (Mtb) ranged from 2 to 32 μg/mL…”
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Effects of a nurse‐led transitional care programme on readmission, self‐efficacy to implement health‐promoting behaviours, functional status and life quality among Chinese patients with coronary artery disease: A randomised controlled trial by Zhang, Pan, Xing, Feng‐Mei, Li, Chang‐Zai, Wang, Feng‐Lan, Zhang, Xiao‐Li

“…Aims and objectives To examine the effectiveness of a nurse‐led transitional care programme on readmission, self‐efficacy to implement health‐promoting…”
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PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness by Yang, Meixiang, Li, Dan, Chang, Zai, Yang, Zhongzhou, Tian, Zhigang, Dong, Zhongjun

“…E4BP4, a circadian protein, is indispensable for NK cell development. It remains largely unknown which signal is required to induce E4BP4 expression and what…”
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Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome by Lu, J. Yuyang, Chang, Lei, Li, Tong, Wang, Ting, Yin, Yafei, Zhan, Ge, Han, Xue, Zhang, Ke, Tao, Yibing, Percharde, Michelle, Wang, Liang, Peng, Qi, Yan, Pixi, Zhang, Hui, Bi, Xianju, Shao, Wen, Hong, Yantao, Wu, Zhongyang, Ma, Runze, Wang, Peizhe, Li, Wenzhi, Zhang, Jing, Chang, Zai, Hou, Yingping, Zhu, Bing, Ramalho-Santos, Miguel, Li, Pilong, Xie, Wei, Na, Jie, Sun, Yujie, Shen, Xiaohua

“…Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation. In…”
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The lncRNA Hand2os1 / Uph locus orchestrates heart development through regulation of precise expression of Hand2 by Han, Xue, Zhang, Jiejie, Liu, Yaxi, Fan, Xiaoying, Ai, Shanshan, Luo, Yingjie, Li, Xin, Jin, Hengwei, Luo, Sai, Zheng, Hui, Yue, Yanzhu, Chang, Zai, Yang, Zhongzhou, Tang, Fuchou, He, Aibin, Shen, Xiaohua

“…Exploration and dissection of potential actions and effects of long noncoding RNA (lncRNA) in animals remain challenging. Here, using multiple knockout mouse…”
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19 Schiff bases as antimycobacterial agents: synthesis, molecular docking and a plausible mechanism of action by Cai, Yu-Xiang, Chen, Jun-Xian, Dong, Hong-Mei, Yang, Zai-Chang

“…To discover novel anti- ( ) drugs, 19 compounds were synthesized; their anti- effects were evaluated and mechanisms of action were preliminarily explored. The…”
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Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development by Zhang, Wenhao, Xia, Weikun, Wang, Qiujun, Towers, Aaron J, Chen, Jiayu, Gao, Rui, Zhang, Yu, Yen, Chia-an, Lee, Ah Young, Li, Yuanyuan, Zhou, Chen, Liu, Kaili, Zhang, Jing, Gu, Tian-Peng, Chen, Xiuqi, Chang, Zai, Leung, Danny, Gao, Shaorong, Jiang, Yong-hui, Xie, Wei

“…The methylcytosine oxidase TET proteins play important roles in DNA demethylation and development. However, it remains elusive how exactly they target…”
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NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation by Yang, Meixiang, Chen, Shasha, Du, Juan, He, Junming, Wang, Yuande, Li, Zehua, Liu, Guangao, Peng, Wanwen, Zeng, Xiaokang, Li, Dan, Xu, Panglian, Guo, Wei, Chang, Zai, Wang, Song, Tian, Zhigang, Dong, Zhongjun

“…Activation of metabolic signalling by IL-15 is required for natural killer (NK) cell development. Here we show that Tsc1, a repressor of mTOR, is dispensable…”
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Compounds Derived from 5‐Fluoropyridine and Benzo[b]thiophene: Killing Mycobacterium tuberculosis and Reducing its Virulence by Dong, Hong‐Mei, Chen, Jun‐Xian, Cai, Yu‐Xiang, Tian, Li‐Xia, Yang, Zai‐Chang

“…The rise of drug‐resistant Mycobacterium tuberculosis (Mtb) has extended the duration of tuberculosis (TB) treatment and reduced the likelihood of cure. One…”
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Synthesis of narrow-spectrum anti-mycobacterial molecules without effect on the diversity of gut microbiota in mice based on the structure of rifampicin by Chen, Jun-Xian, Dong, Hong-Mei, Cai, Yu-Xiang, Tian, Li-Xia, Yang, Zai-Chang

“…[Display omitted] •Sixteen narrow-spectrum anti-Mtb molecules were synthesized.•Compound 3c (2-((6-hydroxynaphthalen-2-yl) methylene)…”
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Vibration Performance of Steel Fiber Concrete Tunnel Lining by Adjacent Tunnel Blasting Construction by Wu, Li-Ming, Wang, Zi-Jian, Chang, Yong-Zai, Gao, Feng, Zhang, Bin, Wu, Yi, Fan, Han-Xiu

“…When constructing tunnels in mountainous areas, the drilling and blasting method is the most commonly used because of its economy. Ordinary reinforced concrete…”
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Effects of a nurse-led transitional care program on clinical outcomes, health-related knowledge, physical and mental health status among Chinese patients with coronary artery disease: A randomized controlled trial by Zhang, Pan, Hu, Yu-ding, Xing, Feng-Mei, Li, Chang-Zai, Lan, Wang-Feng, Zhang, Xiao-Li

“…Coronary artery disease is a major cause of morbidity and mortality among adults worldwide, including China. After a hospital stay, transitional care could…”
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Bioassay-guided isolation of a Mycobacterium tuberculosis bioflim inhibitor from Arisaema sinii Krause by Jiang, Chang-He, Gan, Meng-Lan, An, Ting-Ting, Yang, Zai-Chang

“…Mycobacterium tuberculosis biofilms harbour drug-tolerant bacteria. Identification of drugs that inhibit biofilm formation could enable the dramatic shortening…”
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S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt by Di, Ruomin, Wu, Xiangqi, Chang, Zai, Zhao, Xia, Feng, Qiuting, Lu, Shuangshuang, Luan, Qing, Hemmings, Brian A, Li, Xinli, Yang, Zhongzhou

“…In the present study, we observed a rapid and robust activation of the ribosomal protein S6K (S6 kinase) provoked by MI (myocardial infarction) in mice. As…”
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The mediating role of emotional intelligence between negative life events and psychological distress among nursing students: A cross-sectional study by Zhang, Pan, Li, Chang-Zai, Zhao, Ya-Ning, Xing, Feng-Mei, Chen, Chang-Xiang, Tian, Xi-Feng, Tang, Qi-Qun

“…Previous studies have highlighted that negative life events and emotional intelligence are significant predictors of mental health. However, whether emotional…”
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PDK1 Regulates Vascular Remodeling and Promotes Epithelial-Mesenchymal Transition in Cardiac Development by Feng, Qiuting, Di, Ruomin, Tao, Fang, Chang, Zai, Lu, Shuangshuang, Fan, Wenjing, Shan, Congjia, Li, Xinli, Yang, Zhongzhou

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality by Ma, Aiping, Wang, Lianmei, Gao, Yunzhou, Chang, Zai, Peng, Haiyong, Zeng, Ni, Gui, Yao-Song, Tian, Xinlun, Li, Xue, Cai, Baiqiang, Zhang, Hongbing, Xu, Kai-Feng

“…This is a study on the role of tuberous sclerosis complex1 (TSC1) mutation and mTOR activation in endothelial cells during angiogenic and embryonic…”
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A novel franchetine type norditerpenoid isolated from the roots of Aconitum carmichaeli Debx. with potential analgesic activity and less toxicity by Wang, Dao-Ping, Lou, Hua-Yong, Huang, Lan, Hao, Xiao-Jiang, Liang, Guang-Yi, Yang, Zai-Chang, Pan, Wei-Dong

“…A new franchetine type C19-diterpenoid alkaloid, guiwuline 1, was isolated from the plant Aconitum carmichaeli Debx. Its structure was established on the basis…”
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