Search Results - "Chang, Yanqi"

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation by Hashimoto, Hideharu, Liu, Yiwei, Upadhyay, Anup K, Chang, Yanqi, Howerton, Shelley B, Vertino, Paula M, Zhang, Xing, Cheng, Xiaodong

“…Cytosine residues in mammalian DNA occur in at least three forms, cytosine (C), 5-methylcytosine (M; 5mC) and 5-hydroxymethylcytosine (H; 5hmC). During…”
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A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability by Pradhan, Sriharsa, Estève, Pierre-Olivier, Chang, Yanqi, Samaranayake, Mala, Upadhyay, Anup K, Horton, John R, Feehery, George R, Cheng, Xiaodong

“…DNA methyltransferase-1 (DNMT1) is involved in CpG methylation, and its stability is known to be regulated by lysine methylation. Now it has been shown that…”
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Structural basis for a pH-sensitive calcium leak across membranes by Chang, Yanqi, Bruni, Renato, Kloss, Brian, Assur, Zahra, Kloppmann, Edda, Rost, Burkhard, Hendrickson, Wayne A., Liu, Qun

“…Calcium homeostasis balances passive calcium leak and active calcium uptake. Human Bax inhibitor–1 (hBI-1) is an antiapoptotic protein that mediates a calcium…”
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Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells by Valente, Sergio, Liu, Yiwei, Schnekenburger, Michael, Zwergel, Clemens, Cosconati, Sandro, Gros, Christina, Tardugno, Maria, Labella, Donatella, Florean, Cristina, Minden, Steven, Hashimoto, Hideharu, Chang, Yanqi, Zhang, Xing, Kirsch, Gilbert, Novellino, Ettore, Arimondo, Paola B, Miele, Evelina, Ferretti, Elisabetta, Gulino, Alberto, Diederich, Marc, Cheng, Xiaodong, Mai, Antonello

“…DNA methyltransferases (DNMTs) are important enzymes involved in epigenetic control of gene expression and represent valuable targets in cancer chemotherapy. A…”
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MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a by Chang, Yanqi, Sun, Lidong, Kokura, Kenji, Horton, John R., Fukuda, Mikiko, Espejo, Alexsandra, Izumi, Victoria, Koomen, John M., Bedford, Mark T., Zhang, Xing, Shinkai, Yoichi, Fang, Jia, Cheng, Xiaodong

“…DNA CpG methylation and histone H3 lysine 9 (H3K9) methylation are two major repressive epigenetic modifications, and these methylations are positively…”
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Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294 by Zhang, Xing, Snyder, James P, Spannhoff, Astrid, Horton, John R, Upadhyay, Anup K, Bedford, Mark T, Chang, Yanqi, Cheng, Xiaodong, Liu, Jin

“…The G9a-like lysine methyltransferases can be inhibited by the small molecule BIX-01294, recently identified through a chemical screen and shown to be capable…”
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Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases by Chang, Yanqi, Ganesh, Thota, Horton, John R., Spannhoff, Astrid, Liu, Jin, Sun, Aiming, Zhang, Xing, Bedford, Mark T., Shinkai, Yoichi, Snyder, James P., Cheng, Xiaodong

“…Dynamic histone lysine methylation involves the activities of modifying enzymes (writers), enzymes removing modifications (erasers), and readers of the histone…”
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An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases by Upadhyay, Anup K., Rotili, Dante, Han, Ji Woong, Hu, Ruogu, Chang, Yanqi, Labella, Donatella, Zhang, Xing, Yoon, Young-sup, Mai, Antonello, Cheng, Xiaodong

“…BIX-01294 and its analogs were originally identified and subsequently designed as potent inhibitors against histone H3 lysine 9 (H3K9) methyltransferases G9a…”
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Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity by Rotili, Dante, Tarantino, Domenico, Marrocco, Biagina, Gros, Christina, Masson, Véronique, Poughon, Valérie, Ausseil, Fréderic, Chang, Yanqi, Labella, Donatella, Cosconati, Sandro, Di Maro, Salvatore, Novellino, Ettore, Schnekenburger, Michael, Grandjenette, Cindy, Bouvy, Celine, Diederich, Marc, Cheng, Xiaodong, Arimondo, Paola B, Mai, Antonello

“…Chemical manipulations performed on the histone H3 lysine 9 methyltransferases (G9a/GLP) inhibitor BIX-01294 afforded novel desmethoxyquinazolines able to…”
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Isolation of a flagellar operon in Azospirillum brasilense and functional analysis of FlbD by Chang, Yanqi, Tang, Tao, Li, Ji-Lun

“…A 10 kb fragment containing fliF, fliH, fliN, motA, flbD, flhA, flhF and fleN genes was cloned from the genomic DNA of Azospirillum brasilense Yu62. These…”
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Dwarf and High Tillering1 represses rice tillering through mediating the splicing of D14 pre-mRNA by Liu, Tianzhen, Zhang, Xin, Zhang, Huan, Cheng, Zhijun, Liu, Jun, Zhou, Chunlei, Luo, Sheng, Luo, Weifeng, Li, Shuai, Xing, Xinxin, Chang, Yanqi, Shi, Cuilan, Ren, Yulong, Zhu, Shanshan, Lei, Cailin, Guo, Xiuping, Wang, Jie, Zhao, Zhichao, Wang, Haiyang, Zhai, Huqu, Lin, Qibing, Wan, Jianmin

“…Strigolactones (SLs) constitute a class of plant hormones that regulate many aspects of plant development, including repressing tillering in rice (Oryza…”
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Ion and pH Sensitivity of a TMBIM Ca2+ Channel by Guo, Gongrui, Xu, Min, Chang, Yanqi, Luyten, Tomas, Seitaj, Bruno, Liu, Wu, Zhu, Ping, Bultynck, Geert, Shi, Lei, Quick, Matthias, Liu, Qun

“…The anti-apoptotic transmembrane Bax inhibitor motif (TMBIM) containing protein family regulates Ca2+ homeostasis, cell death, and the progression of diseases…”
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Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling by Chang, Yanqi, Levy, Dan, Horton, John R, Peng, Junmin, Zhang, Xing, Gozani, Or, Cheng, Xiaodong

“…SET domain containing 6 (SETD6) monomethylates the RelA subunit of nuclear factor kappa B (NF-κB). The ankyrin repeats of G9a-like protein (GLP) recognizes…”
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OsPRMT6a-mediated arginine methylation of OsJAZ1 regulates jasmonate signaling and spikelet development in rice by Dong, Kun, Wu, Fuqing, Cheng, Siqi, Li, Shuai, Zhang, Feng, Xing, Xinxin, Jin, Xin, Luo, Sheng, Feng, Miao, Miao, Rong, Chang, Yanqi, Zhang, Shuang, You, Xiaoman, Wang, Peiran, Zhang, Xin, Lei, Cailin, Ren, Yulong, Zhu, Shanshan, Guo, Xiuping, Wu, Chuanyin, Yang, Dong-Lei, Lin, Qibing, Cheng, Zhijun, Wan, Jianmin

“…Although both protein arginine methylation (PRMT) and jasmonate (JA) signaling are crucial for regulating plant development, the relationship between these…”
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Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling by Gozani, Or, Levy, Dan, Kuo, Alex J, Chang, Yanqi, Schaefer, Uwe, Kitson, Christopher, Cheung, Peggie, Espejo, Alexsandra, Zee, Barry M, Liu, Chih Long, Tangsombatvisit, Stephanie, Tennen, Ruth I, Kuo, Andrew Y, Tanjing, Song, Cheung, Regina, Chua, Katrin F, Utz, Paul J, Shi, Xiaobing, Prinjha, Rab K, Lee, Kevin, Garcia, Benjamin A, Bedford, Mark T, Tarakhovsky, Alexander, Cheng, Xiaodong

“…Binding of the transcription factor NF-κB subunit RelA activates proinflammatory gene expression. Gozani and colleagues show that basal expression of RelA…”
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Ion and pH Sensitivity of a TMBIM Ca2+ Channel by Guo, Gongrui, Xu, Min, Chang, Yanqi, Luyten, Tomas, Seitaj, Bruno, Liu, Wu, Zhu, Ping, Bultynck, Geert, Shi, Lei, Quick, Matthias, Liu, Qun

“…The anti-apoptotic transmembrane Bax inhibitor motif (TMBIM) containing protein family regulates Ca2+ homeostasis, cell death, and diseases including cancers…”
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Structural Insights for MPP8 Chromodomain Interaction with Histone H3 Lysine 9: Potential Effect of Phosphorylation on Methyl-Lysine Binding by Chang, Yanqi, Horton, John R., Bedford, Mark T., Zhang, Xing, Cheng, Xiaodong

“…M-phase phosphoprotein 8 (MPP8) harbors an N-terminal chromodomain and a C-terminal ankyrin repeat domain. MPP8, via its chromodomain, binds histone H3 peptide…”
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Ion and pH Sensitivity of a TMBIM Ca 2+ Channel by Guo, Gongrui, Xu, Min, Chang, Yanqi, Luyten, Tomas, Seitaj, Bruno, Liu, Wu, Zhu, Ping, Bultynck, Geert, Shi, Lei, Quick, Matthias, Liu, Qun

“…The anti-apoptotic transmembrane Bax inhibitor motif (TMBIM) containing protein family regulates Ca homeostasis, cell death, and the progression of diseases…”
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Multi-crystal native SAD analysis at 6keV by Liu, Qun, Guo, Youzhong, Chang, Yanqi, Cai, Zheng, Assur, Zahra, Mancia, Filippo, Greene, Mark I, Hendrickson, Wayne A

“…Anomalous diffraction signals from typical native macromolecules are very weak, frustrating their use in de novo structure determination. Here, native SAD…”
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Multi-crystal native SAD analysis at 6 keV by Liu, Qun, Guo, Youzhong, Chang, Yanqi, Cai, Zheng, Assur, Zahra, Mancia, Filippo, Greene, Mark I., Hendrickson, Wayne A.

“…Anomalous diffraction signals from typical native macromolecules are very weak, frustrating their use in de novo structure determination. Here, native SAD…”
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