Search Results - "Chang, Thomas H."

High-level cognition during story listening is reflected in high-order dynamic correlations in neural activity patterns by Owen, Lucy L. W., Chang, Thomas H., Manning, Jeremy R.

“…Our thoughts arise from coordinated patterns of interactions between brain structures that change with our ongoing experiences. High-order dynamic correlations…”
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Synthetic Drugs and Natural Products as Modulators of Constitutive Androstane Receptor (Car) and Pregnane X Receptor (PXR) by Chang, Thomas K. H., Waxman, David J.

“…Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are members of the nuclear receptor superfamily. These transcription factors are…”
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Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes by Surendradoss, Jayakumar, Chang, Thomas K.H., Abbott, Frank S.

“…Valproic acid (VPA) undergoes cytochrome P450-mediated desaturation to form 4-ene-VPA, which subsequently yields (E)-2,4-diene-VPA by β-oxidation. Another…”
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Inhibition of Human CYP2B6-Catalyzed Bupropion Hydroxylation by Ginkgo biloba Extract: Effect of Terpene Trilactones and Flavonols by LAU, Aik Jiang, CHANG, Thomas K. H

“…Cytochrome P450 2B6 (CYP2B6) is expressed predominantly in human liver. It catalyzes the oxidative biotransformation of various drugs, including bupropion,…”
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Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity by Kiang, Tony K.L., Teng, Xiao Wei, Surendradoss, Jayakumar, Karagiozov, Stoyan, Abbott, Frank S., Chang, Thomas K.H.

“…The present study was conducted in sandwich-cultured rat hepatocytes to investigate the chemical basis of glutathione (GSH) depletion by valproic acid (VPA)…”
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Identification of Ginkgo biloba as a Novel Activator of Pregnane X Receptor by YEUNG, Eugene Y. H, SUEYOSHI, Tatsuya, NEGISHI, Masahiko, CHANG, Thomas K. H

“…Pregnane X receptor (PXR; NR1I2 ) is a ligand-activated transcription factor that plays a role not only in drug metabolism and transport but also in various…”
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Role of Oxidative Metabolism in the Effect of Valproic Acid on Markers of Cell Viability, Necrosis, and Oxidative Stress in Sandwich-Cultured Rat Hepatocytes by Kiang, Tony K. L., Teng, Xiao Wei, Karagiozov, Stoyan, Surendradoss, Jayakumar, Chang, Thomas K. H., Abbott, Frank S.

“…Valproic acid (VPA) is a drug known for idiosyncratic hepatotoxicity and is associated with oxidative stress. It is metabolized extensively with at least one…”
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Valproic Acid I: Time Course of Lipid Peroxidation Biomarkers, Liver Toxicity, and Valproic Acid Metabolite Levels in Rats by Tong, Vincent, Teng, Xiao Wei, Chang, Thomas K. H., Abbott, Frank S.

“…A single dose of valproic acid (VPA), which is a widely used antiepileptic drug, is associated with oxidative stress in rats, as recently demonstrated by…”
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Valproic Acid II: Effects on Oxidative Stress, Mitochondrial Membrane Potential, and Cytotoxicity in Glutathione-Depleted Rat Hepatocytes by Tong, Vincent, Teng, Xiao Wei, Chang, Thomas K. H., Abbott, Frank S.

“…Oxidative stress has been associated with valproic acid (VPA) treatment, and mitochondrial dysfunction has been implicated in the pathogenesis of…”
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Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines by Chang, Thomas K. H.

“…Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription factors that control the expression of a broad array of genes involved…”
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Constitutive Androstane Receptor and Pregnane X Receptor Gene Expression in Human Liver: Interindividual Variability and Correlation with CYP2B6 mRNA Levels by CHANG, Thomas K. H, BANDIERA, Stelvio M, JIE CHEN

“…The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mediate the expression of mammalian cytochrome P450 (P450) 2B genes, including CYP2B6…”
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Developmental Expression and Endocrine Regulation of CYP1B1 in Rat Testis by LEUNG, Grace S, KAWAI, Masahiko, TAI, Jenny K, JIE CHEN, BANDIERA, Stelvio M, CHANG, Thomas K. H

“…Mammalian testis expresses xenobiotic-metabolizing enzymes, including cytochrome P450 1B1 (CYP1B1), which catalyzes the bioactivation of procarcinogens and…”
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DISTINCT ROLE OF BILOBALIDE AND GINKGOLIDE A IN THE MODULATION OF RAT CYP2B1 AND CYP3A23 GENE EXPRESSION BY GINKGO BILOBA EXTRACT IN CULTURED HEPATOCYTES by Chang, Thomas K H, Chen, Jie, Teng, Xiao Wei

“…In the present study, primary cultures of rat hepatocytes were treated for 48 h with one of several extracts of Ginkgo biloba (10, 100, or 1000 μg/ml)…”
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Negative Regulation of Human Pregnane X Receptor by MicroRNA-18a-5p: Evidence for Suppression of MicroRNA-18a-5p Expression by Rifampin and Rilpivirine by Sharma, Devinder, Turkistani, Abdullah A, Chang, Wenjun, Hu, Catherine, Xu, Zhaoming, Chang, Thomas K H

“…Small noncoding microRNAs act as post-transcriptional regulators of gene expression involved in diverse biologic functions. Pregnane X receptor (PXR, NR1I2), a…”
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In Vitro Effect of Standardized Ginseng Extracts and Individual Ginsenosides on the Catalytic Activity of Human CYP1A1, CYP1A2, and CYP1B1 by Chang, Thomas K H, Chen, Jie, Benetton, Salete A

“…Ginseng extract has been reported to decrease the incidence of 7,12-dimethylbenz[ a ]anthracene (DMBA)-initiated tumorigenesis in mice. A potential mechanism…”
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Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells by Rajaraman, Ganesh, Yang, Guixiang, Chen, Jie, Chang, Thomas K H

“…The aryl hydrocarbon receptor (AhR) signaling pathway regulates the production of CYP1B1 and CYP1A1, which catalyze the bioactivation of various…”
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Localization of cytochrome P450 and related enzymes in adult rat testis and downregulation by estradiol and bisphenol A by Gilibili, Ravindranath Reddy, Vogl, A Wayne, Chang, Thomas K H, Bandiera, Stelvio M

“…There is a growing body of evidence that exposure to endocrine disrupting chemicals and to estrogenic compounds in particular can affect the testis and male…”
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Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides by Lau, Aik Jiang, Yang, Guixiang, Rajaraman, Ganesh, Baucom, Christie C, Chang, Thomas K H

“…Ginkgo biloba extract activates pregnane X receptor (PXR), but how this occurs is not known. Therefore, we investigated the mechanism of PXR activation by the…”
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Fetal bovine serum and human constitutive androstane receptor: Evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system by Lau, Aik Jiang, Chang, Thomas K.H.

“…The naturally occurring SV23 splice variant of human constitutive androstane receptor (hCAR-SV23) is activated by di-(2-ethylhexyl)phthalate (DEHP), which is…”
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Selective agonism of human pregnane X receptor by individual ginkgolides by Lau, Aik Jiang, Yang, Guixiang, Yap, Chun Wei, Chang, Thomas K H

“…Ginkgolide A, ginkgolide B, ginkgolide C, and ginkgolide J are structurally related terpene trilactones present in Ginkgo biloba extract. Pregnane X receptor…”
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