Search Results - "Chang, Theresa L"

ACE2-Independent Alternative Receptors for SARS-CoV-2 by Lim, Suhyeon, Zhang, Monica, Chang, Theresa L

“…Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is highly contagious and…”
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Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry by Xu, Chuan, Wang, Annie, Marin, Mariana, Honnen, William, Ramasamy, Santhamani, Porter, Edith, Subbian, Selvakumar, Pinter, Abraham, Melikyan, Gregory B., Lu, Wuyuan, Chang, Theresa L.

“…Innate immunity during acute infection plays a critical role in the disease severity of severe acute respiratory syndrome (SARS) and Middle East respiratory…”
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Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture by Bakovic, Allison, Risner, Kenneth, Bhalla, Nishank, Alem, Farhang, Chang, Theresa L, Weston, Warren K, Harness, Jane A, Narayanan, Aarthi

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the newly emergent causative agent of coronavirus disease-19 (COVID-19), has resulted in more…”
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Differential Effects of Antiseptic Mouth Rinses on SARS-CoV-2 Infectivity In Vitro by Xu, Chuan, Wang, Annie, Hoskin, Eileen R, Cugini, Carla, Markowitz, Kenneth, Chang, Theresa L, Fine, Daniel H

“…Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) is detectable in saliva from asymptomatic individuals, suggesting a potential benefit from…”
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Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry Mechanisms by Xu, Chuan, Wang, Annie, Geng, Ke, Honnen, William, Wang, Xuening, Bruiners, Natalie, Singh, Sukhwinder, Ferrara, Fortunato, D'Angelo, Sara, Bradbury, Andrew R M, Gennaro, Maria Laura, Liu, Dongfang, Pinter, Abraham, Chang, Theresa L

“…Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), the causative agent of coronavirus disease 19 (COVID-19), enters cells through attachment…”
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Modulation of HIV transmission by Neisseria gonorrhoeae: molecular and immunological aspects by Jarvis, Gary A, Chang, Theresa L

“…Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial…”
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Key Determinants of Human α-Defensin 5 and 6 for Enhancement of HIV Infectivity by Valere, Kimyata, Lu, Wuyuan, Chang, Theresa L

“…Defensins are antimicrobial peptides important for mucosal innate immunity. They exhibit a broad spectrum of activity against bacteria, viruses, and fungi…”
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Microbiome in Human Immunodeficiency Virus Infection by Salas, January T., PhD, Chang, Theresa L., PhD

“…Human immunodeficiency virus (HIV) primary infection occurs at mucosa tissues, suggesting an intricate interplay between the microbiome and HIV infection…”
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Comprehensive Analysis of Disease Pathology in Immunocompetent and Immunocompromised Hosts following Pulmonary SARS-CoV-2 Infection by Ramasamy, Santhamani, Kolloli, Afsal, Kumar, Ranjeet, Husain, Seema, Soteropoulos, Patricia, Chang, Theresa L., Subbian, Selvakumar

“…The Coronavirus disease 2019 (COVID-19) pandemic disproportionately affects immunocompetent and immunocompromised individuals, with the latter group being more…”
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Differential effects of depot medroxyprogesterone acetate administration on vaginal microbiome in Hispanic White and Black women by Yang, Liying, Hao, Yuhan, Hu, Jiyuan, Kelly, Dervla, Li, Huilin, Brown, Stuart, Tasker, Carley, Roche, Natalie E., Chang, Theresa L., Pei, Zhiheng

“…The use of depot medroxyprogesterone acetate (DMPA), a 3-monthly injectable hormonal contraceptive, is associated with an increased risk of HIV acquisition…”
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Multifaceted immune functions of human defensins and underlying mechanisms by Fruitwala, Saahil, El-Naccache, Darine W., Chang, Theresa L.

“…Defensins have been long recognized as natural antimicrobial peptides, but they also possess diverse and versatile immune functions. Defensins can both induce…”
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Influence of the tryptophan-indole-IFNγ axis on human genital Chlamydia trachomatis infection: role of vaginal co-infections by Aiyar, Ashok, Quayle, Alison J, Buckner, Lyndsey R, Sherchand, Shardulendra P, Chang, Theresa L, Zea, Arnold H, Martin, David H, Belland, Robert J

“…The natural history of genital Chlamydia trachomatis infections can vary widely; infections can spontaneously resolve but can also last from months to years,…”
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3D host cell and pathogen-based bioassay development for testing anti-tuberculosis (TB) drug response and modeling immunodeficiency by Mukundan, Shilpaa, Bhatt, Rachana, Lucas, John, Tereyek, Matthew, Chang, Theresa L., Subbian, Selvakumar, Parekkadan, Biju

“…Tuberculosis (TB) is a global health threat that affects 10 million people worldwide. Human Immunodeficiency Virus (HIV) remains one of the major contributors…”
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Neisseria gonorrhoeae-Induced Human Defensins 5 and 6 Increase HIV Infectivity: Role in Enhanced Transmission by Klotman, Mary E, Rapista, Aprille, Teleshova, Natalia, Micsenyi, Amanda, Jarvis, Gary A, Lu, Wuyuan, Porter, Edith, Chang, Theresa L

“…Sexually transmitted infections (STIs) increase the likelihood of HIV transmission. Defensins are part of the innate mucosal immune response to STIs and…”
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Oral Epithelial Cells Expressing Low or Undetectable Levels of Human Angiotensin-Converting Enzyme 2 Are Susceptible to SARS-CoV-2 Virus Infection In Vitro by Ebraham, Laith, Xu, Chuan, Wang, Annie, Hernandez, Cyril, Siclari, Nicholas, Rajah, Divino, Walter, Lewins, Marras, Salvatore A E, Tyagi, Sanjay, Fine, Daniel H, Daep, Carlo Amorin, Chang, Theresa L

“…The oral cavity is thought to be one of the portals for SARS-CoV-2 entry, although there is limited evidence of active oral infection by SARS-CoV-2 viruses. We…”
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Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment by Rapista, Aprille, Ding, Jian, Benito, Bernadette, Lo, Yung-Tai, Neiditch, Matthew B, Lu, Wuyuan, Chang, Theresa L

“…Concurrent sexually transmitted infections (STIs) increase the likelihood of HIV transmission. The levels of defensins are frequently elevated in genital…”
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Inhibition of HIV Infectivity by a Natural Human Isolate of Lactobacillus jensenii Engineered to Express Functional Two-Domain CD4 by Theresa L. -Y. Chang, Chang, Chia-Hwa, Simpson, David A., Xu, Qiang, Martin, Patrick K., Lagenaur, Laurel A., Schoolnik, Gary K., Ho, David D., Hillier, Sharon L., Holodniy, Mark, Lewicki, John A., Lee, Peter P.

“…The predominant mode of HIV transmission worldwide is via heterosexual contact, with the cervico-vaginal mucosa being the main portal of entry in women. The…”
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Defensins in Viral Infections by Ding, Jian, Chou, Yi-Ying, Chang, Theresa L.

“…Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses…”
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Anti-HIV activity of human defensin 5 in primary CD4+ T cells under serum-deprived conditions is a consequence of defensin-mediated cytotoxicity by Ding, Jian, Tasker, Carley, Valere, Kimyata, Sihvonen, Tiina, Descalzi-Montoya, Dante B, Lu, Wuyuan, Chang, Theresa L

“…We have previously shown that human defensin 5 (HD5) promotes HIV infectivity in both primary CD4+ T cells and HeLa cells expressing CD4 and CCR5. HD5 is…”
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ERRγ, a new player in the type I IFN arena by Xu, Chuan, Chang, Theresa L.

“…Graphical Discussion on how the nuclear orphan receptor ERRγ induces type I IFNs and impacts the estrogenic response in host defense and disease progression…”
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