Search Results - "Chang, Stephanie S"

Guidance of Cell Migration by Substrate Dimension by Chang, Stephanie S., Guo, Wei-hui, Kim, Youngeun, Wang, Yu-li

“…There is increasing evidence to suggest that physical parameters, including substrate rigidity, topography, and cell geometry, play an important role in cell…”
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Reversible covalent direct thrombin inhibitors by Sivaraja, Mohanram, Pozzi, Nicola, Rienzo, Matthew, Lin, Kenneth, Shiau, Timothy P, Clemens, Daniel M, Igoudin, Lev, Zalicki, Piotr, Chang, Stephanie S, Estiarte, M Angels, Short, Kevin M, Williams, David C, Datta, Anirban, Di Cera, Enrico, Kita, David B

“…In recent years, the traditional treatments for thrombotic diseases, heparin and warfarin, are increasingly being replaced by novel oral anticoagulants…”
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Migration regulates cellular mechanical states by Chang, Stephanie S, Rape, Andrew D, Wong, Stephanie A, Guo, Wei-Hui, Wang, Yu-Li

“…Recent studies indicate that adherent cells are keenly sensitive to external physical environment, such as substrate rigidity and topography, and internal…”
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VE-1902—A direct thrombin inhibitor with reversible covalent mechanism of action shows efficacy with reduced bleeding in rodent models of thrombosis by Sivaraja, Mohanram, Clemens, Daniel M., Sizikov, Sivan, Dash, Subhadra, Xu, Chengpei, Rienzo, Matthew, Yang, Bo, Ryan, Molly, Chattopadhyay, Madhuri, Igoudin, Lev, Chang, Stephanie S., Keutzer, Samuel, Zalicki, Piotr, Estiarte, M. Angels, Shiau, Timothy P., Short, Kevin M., Williams, David C., Datta, Anirban, Pozzi, Nicola, Di Cera, Enrico, Gibson, C. Michael, Fox, Keith A.A., Kita, David B.

“…High incidence of bleeding events remains a key risk for patients taking anticoagulants, especially those in need of long-term combination therapy with…”
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Abstract 1260: First-in-class, orally bioavailable KRASG12V(ON) tri-complex inhibitors, as single agents and in combinations, drive profound anti-tumor activity in preclinical models of KRASG12V mutant cancers by Koltun, Elena, Cregg, Jim, Rice, Meghan A., Whalen, Dan M., Freilich, Rebecca, Jiang, Jingjing, Hansen, Richard, Bermingham, Alun, Knox, John E., Dinglasan, Jay, Seamon, Kyle, Blaj, Cristina, Chang, Stephanie S., Liu, Yang, Huang, Jun, Chou, Kang-Jye, McDowell, Laura, Lee, Bianca J., Wildes, David, Wang, Zhengping, Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A.

“…Abstract KRASG12V mutant cancers represent a significant unmet medical need with nearly 44,000 new diagnoses annually in the US. The KRASG12V mutation occurs…”
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αB-Crystallin Improves Murine Cardiac Function and Attenuates Apoptosis in Human Endothelial Cells Exposed to Ischemia-Reperfusion by Velotta, Jeffrey B., MD, Kimura, Naoyuki, MD, Chang, Stephanie H., BS, Chung, Jaehoon, MD, Itoh, Satoshi, MD, Rothbard, Jonathan, PhD, Yang, Philip C., MD, Steinman, Lawrence, MD, Robbins, Robert C., MD, Fischbein, Michael P., MD, PhD

“…Background This study investigates the protective effect of exogenous αB-crystallin (CryAB) on myocardial function after ischemia-reperfusion injury. Methods…”
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