Search Results - "Chang, Stacey"
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Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule
Published in Nature structural & molecular biology (01-06-2019)“…The drug-like molecule PF-06446846 (PF846) binds the human ribosome and selectively blocks the translation of a small number of proteins by an unknown…”
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2
Selective inhibition of human translation termination by a drug-like compound
Published in Nature communications (02-10-2020)“…Methods to directly inhibit gene expression using small molecules hold promise for the development of new therapeutics targeting proteins that have evaded…”
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Immediate birth for women between 34 and 37 weeks of gestation with prolonged preterm prelabour rupture of membranes and detection of vaginal or urine group B streptococcus: an economic evaluation
Published in BJOG : an international journal of obstetrics and gynaecology (01-09-2022)“…Objective What are the costs, benefits and harms of immediate birth compared with expectant management in women with prolonged preterm prelabour rupture of…”
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4
A highly efficient human cell-free translation system
Published in RNA (Cambridge) (01-12-2023)“…Cell-free protein synthesis (CFPS) systems enable easy in vitro expression of proteins with many scientific, industrial, and therapeutic applications. Here we…”
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Examining the Real-Life Journey of Individuals and Families Affected by Single-Ventricle Congenital Heart Disease
Published in Journal of the American Heart Association (07-03-2023)“…Background The lifetime journey of patients with single-ventricle congenital heart disease is characterized by long-term challenges that are incompletely…”
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Network Meta-Analysis of Tofacitinib, Biologic Disease-Modifying Antirheumatic Drugs, and Apremilast for the Treatment of Psoriatic Arthritis
Published in Current therapeutic research (01-01-2020)“…Tofacitinib and other new treatments approved for use in psoriatic arthritis have only recently been included in psoriatic arthritis treatment guidelines, and…”
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7
Beyond Evidence-Based Medicine
Published in The New England journal of medicine (22-11-2018)“…Evidence-based medicine shifted medicine’s center of gravity away from the space between clinician and patient. A new “interpersonal medicine” would be a…”
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The presence of preoperative neurodegeneration biofluid markers in patients with postoperative delirium
Published in Anesthesiology (Philadelphia) (01-10-2023)“…The pathophysiology of delirium is incompletely understood, including what molecular pathways are involved in brain vulnerability to delirium. This study…”
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Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial
Published in Anesthesiology (Philadelphia) (01-10-2017)“…BACKGROUND:Postoperative pain and opioid use are associated with postoperative delirium. We designed a single-center, randomized, placebo-controlled,…”
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10
Cannabis-based medicinal products: summary of NICE guidance
Published in BMJ (Online) (21-04-2020)“…Do not offer CBD to manage chronic pain in adults unless as part of a clinical trial In September 2018, in light of the UK chief medical officer’s review and…”
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Cost-effectiveness of asenapine in the treatment of bipolar I disorder patients with mixed episodes
Published in Journal of medical economics (01-07-2014)“…Around one-third of patients with bipolar I disorder (BD-I) experience mixed episodes, characterized by both mania and depression, which tend to be more…”
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Costs and Health Outcomes Associated with Tofacitinib Treatment for Active Psoriatic Arthritis in the United States
Published in Journal of managed care & specialty pharmacy (01-08-2020)“…Psoriatic arthritis (PsA) is a chronic progressive inflammatory condition associated with significant direct and indirect costs. Tofacitinib is an oral Janus…”
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