Search Results - "Chang, Pamela V"

Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor by Scott, Samantha A., Fu, Jingjing, Chang, Pamela V.

“…Inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis, are associated with dysbiosis of the gut microbiome. Emerging evidence…”
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microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition by Chang, Pamela V., Hao, Liming, Offermanns, Stefan, Medzhitov, Ruslan

“…Given the trillions of microbes that inhabit the mammalian intestines, the host immune system must constantly maintain a balance between tolerance to…”
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Copper-free click chemistry in living animals by Chang, Pamela V, Prescher, Jennifer A, Sletten, Ellen M, Baskin, Jeremy M, Miller, Isaac A, Agard, Nicholas J, Lo, Anderson, Bertozzi, Carolyn R

“…Chemical reactions that enable selective biomolecule labeling in living organisms offer a means to probe biological processes in vivo. Very few reactions…”
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Copper-free click chemistry for dynamic in vivo imaging by Baskin, Jeremy M, Prescher, Jennifer A, Laughlin, Scott T, Agard, Nicholas J, Chang, Pamela V, Miller, Isaac A, Lo, Anderson, Codelli, Julian A, Bertozzi, Carolyn R

“…Dynamic imaging of proteins in live cells is routinely performed by using genetically encoded reporters, an approach that cannot be extended to other classes…”
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Chemical optogenetic modulation of inflammation and immunity by Parasar, Bibudha, Chang, Pamela V

“…The immune system is an essential component of host defense against pathogens and is largely mediated by inflammatory molecules produced by immune cells, such…”
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Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars by Chang, Pamela V, Chen, Xing, Smyrniotis, Chris, Xenakis, Alexander, Hu, Tianshun, Bertozzi, Carolyn R, Wu, Peng

“…Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great…”
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Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity by Parasar, Bibudha, Zhou, Hao, Xiao, Xieyue, Shi, Qiaojuan, Brito, Ilana L, Chang, Pamela V

“…The metagenome of the gut microbiome encodes tremendous potential for biosynthesizing and transforming small-molecule metabolites through the activities of…”
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A Strategy for the Selective Imaging of Glycans Using Caged Metabolic Precursors by Chang, Pamela V, Dube, Danielle H, Sletten, Ellen M, Bertozzi, Carolyn R

“…Glycans can be imaged by metabolic labeling with azidosugars followed by chemical reaction with imaging probes; however, tissue-specific labeling is difficult…”
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Finding the Sweet Spot for Breast Cancer Detection by Parasar, Bibudha, Chang, Pamela V

“…Dual detection of enzymatic activities enables discrimination of benign, malignant, and normal breast tissue in human patient samples…”
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Deciphering the Chemical Lexicon of Host–Gut Microbiota Interactions by Nicolas, Gael R., Chang, Pamela V.

“…The human intestine harbors an immense, diverse, and critical population of bacteria that has effects on numerous aspects of host physiology, immunity, and…”
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Microbial metabolite-receptor interactions in the gut microbiome by Chang, Pamela V.

“…The gut microbiome impacts many physiological processes that greatly influence host health and disease. Metabolites produced by the gut microbiota have emerged…”
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Activity-based protein profiling in microbes and the gut microbiome by Han, Lin, Chang, Pamela V.

“…Activity-based protein profiling (ABPP) is a powerful chemical approach for probing protein function and enzymatic activity in complex biological systems. This…”
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Dopamine receptor D2 confers colonization resistance via microbial metabolites by Scott, Samantha A., Fu, Jingjing, Chang, Pamela V.

“…The gut microbiome has major roles in modulating host physiology. One such function is colonization resistance, or the ability of the microbial collective to…”
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BSH-TRAP: Bile salt hydrolase tagging and retrieval with activity-based probes by Parasar, Bibudha, Chang, Pamela V

“…Bile acids are important molecules that participate in digestion and regulate many host physiological processes, including metabolism and inflammation. Primary…”
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Designer Dendrons To Dissect Innate Immune Signaling by Chang, Pamela V, Grimes, Catherine L

“…Structure-based design of new polymeric inflammasome activators that control immune responses could lead to better vaccines and immunotherapies…”
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Engineered Th17 Cell Differentiation Using a Photoactivatable Immune Modulator by Parasar, Bibudha, Chang, Pamela V

“…T helper 17 (Th17) cells, an important subset of CD4+ T cells, help to eliminate extracellular infectious pathogens that have invaded our tissues. Despite the…”
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Electrostatic Interactions Dictate Bile Salt Hydrolase Substrate Preference by Malarney, Kien P., Chang, Pamela V.

“…The human intestines are colonized by trillions of microbes, comprising the gut microbiota, which produce diverse small molecule metabolites and modify host…”
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Chemical Mechanisms of Colonization Resistance by the Gut Microbial Metabolome by Chang, Pamela V

“…The gut microbiome, the collection of 100 trillion microorganisms that resides in the intestinal lumen, plays major roles in modulating host physiology. One…”
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Shedding Light on Bacterial Physiology with Click Chemistry by Zheng, Qiuyu, Chang, Pamela V.

“…Bacteria constitute a major lifeform on this planet and play numerous roles in ecology, physiology, and human disease. However, conventional methods to probe…”
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Imaging beyond the proteome by Chang, Pamela V, Bertozzi, Carolyn R

“…Imaging technologies developed in the early 20th century achieved contrast solely by relying on macroscopic and morphological differences between the tissues…”
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