Search Results - "Chang, Linda L."

Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors by Chu, Lin, Armstrong, Helen M., Chang, Linda L., Cheng, Amy F., Colwell, Lawrence, Cui, Jisong, Evans, Jilly, Galka, Amy, Goulet, Mark T., Hayes, Nancy, Lo, Jane, Menke, John, Ok, Hyun O., Ondeyka, Debra L., Patel, Minal, Quaker, Grace M., Sings, Heather, Witkin, Stephanie L., Zhao, Annie, Ujjainwalla, Feroze

“…The investigation of endo and exo-aryl substitutions and the discovery of the tert-butyl group as a central scaffold on the novel class of FLAP inhibitors are…”
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Single-Point Assessment of Warfarin Use and Risk of Osteoporosis in Elderly Men by Woo, Claudine, Chang, Linda L., Ewing, Susan K., Bauer, Douglas C.

“…OBJECTIVES: To determine whether warfarin use, assessed at a single point in time, is associated with bone mineral density (BMD), rates of bone loss, and…”
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Comparative Assessment of the Ligand and Metal Ion Binding Properties of Integrins α9β1 and α4β1 by Pepinsky, R. Blake, Mumford, Richard A, Chen, Ling Ling, Leone, Diane, Amo, Suzanne E, Riper, Gail Van, Whitty, Adrian, Dolinski, Brian, Lobb, Roy R, Dean, Dennis C, Chang, Linda L, Raab, Conrad E, Si, Qian, Hagmann, William K, Lingham, Russell B

“…Integrins α9β1 and α4β1 form a distinct structural class, but while α4β1 has been subjected to extensive study, α9β1 remains poorly characterized. We have used…”
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Constraining the amide bond in N-Sulfonylated dipeptide VLA-4 antagonists by Chang, Linda L., Yang, Ginger X., McCauley, Ermengilda, Mumford, Richard A., Schmidt, John A., Hagmann, William K.

“…The integrin VLA-4 is implicated in several inflammatory disease states. In search of non-peptidic antagonists of VLA-4, rotational constraints were imposed on…”
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Highly constrained bicyclic VLA-4 antagonists by Chang, Linda L., Truong, Quang, Doss, George A., MacCoss, Malcolm, Lyons, Kathryn, McCauley, Ermengilda, Mumford, Richard, Forrest, Gail, Vincent, Stella, Schmidt, John A., Hagmann, William K.

“…VLA-4 antagonists containing a bicyclic β-amino acid were studied. Activity was found to be related to the P 3-amino-carboxy dihedral angle in the bicycle. The…”
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Substituted Imidazoles as Glucagon Receptor Antagonists by Chang, Linda L., Sidler, Kelly L., Cascieri, Margaret A., de Laszlo, Stephen, Koch, Greg, Li, Bing, MacCoss, Malcolm, Mantlo, Nathan, O'Keefe, Stephen, Pang, Margaret, Rolando, Anna, Hagmann, William K.

“…A modestly active, nonselective triarylimidazole lead was optimized for binding affinity with the human glucagon receptor. This led to the identification of a…”
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The Effects of Using CALL on Advanced Chinese Foreign Language Learners by Chang, Linda L.

“…This study investigates the effect of a CALL application designed to enhance speaking and listening in Mandarin Chinese on advanced students' verbal skills,…”
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Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists by Armstrong, Helen E., Galka, Amy, Lin, Linus S., Lanza, Thomas J., Jewell, James P., Shah, Shrenik K., Guthikonda, Ravi, Truong, Quang, Chang, Linda L., Quaker, Grace, Colandrea, Vincent J., Tong, Xinchun, Wang, Junying, Xu, Sherry, Fong, Tung M., Shen, Chun-Pyn, Lao, Julie, Chen, Jing, Shearman, Lauren P., Stribling, D. Sloan, Rosko, Kimberly, Strack, Alison, Ha, Sookhee, der Ploeg, Lex Van, Goulet, Mark T., Hagmann, William K.

“…Sulfonamide analogues of the potent CB1R inverse agonist 2 (Taranabant) were optimized for CB1R activity. Sulfonamide analogues of the potent CB1R inverse…”
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The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists by Hagmann, William K, Durette, Philippe L, Lanza, Thomas, Kevin, Nancy Jo, de Laszlo, Stephen E, Kopka, Ihor E, Young, David, Magriotis, Plato A, Li, Bing, Lin, Linus S, Yang, Ginger, Kamenecka, Theodore, Chang, Linda L, Wilson, Jonathan, MacCoss, Malcolm, Mills, Sander G, Van Riper, Gail, McCauley, Ermengilda, Egger, Linda A, Kidambi, Usha, Lyons, Kathryn, Vincent, Stella, Stearns, Ralph, Colletti, Adria, Teffera, Johannes, Tong, Sharon, Fenyk-Melody, Judy, Owens, Karen, Levorse, Dorothy, Kim, Philip, Schmidt, John A, Mumford, Richard A

“…Directed screening of a carboxylic acid-containing combinatorial library led to the discovery of potent inhibitors of the integrin VLA-4. Subsequent…”
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The discovery of small molecule carbamates as potent dual α4β1/α4β7 integrin antagonists by CHANG, Linda L, TRUONG, Quang, MACCOSS, Malcolm, HAGMANN, William K, MUMFORD, Richard A, EGGER, Linda A, KIDAMBI, Usha, LYONS, Kathryn, MCCAULEY, Ermengilda, VAN RIPER, Gail, VINCENT, Stella, SCHMIDT, John A

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N-Tetrahydrofuroyl-( l)-phenylalanine derivatives as potent VLA-4 antagonists by Yang, Ginger X., Chang, Linda L., Truong, Quang, Doherty, George A., Magriotis, Plato A., de Laszlo, Stephen E., Li, Bing, MacCoss, Malcolm, Kidambi, Usha, Egger, Linda A., McCauley, Ermengilda, Van Riper, Gail, Mumford, Richard A., Schmidt, John A., Hagmann, William K.

“…Given the proposed involvement of VLA-4 in inflammatory processes, a program to identify orally active VLA-4 antagonists was initiated. Herein, we report the…”
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Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists by Doherty, George A., Yang, Ginger X., Borges, Edite, Chang, Linda L., MacCoss, Malcolm, Tong, Sharon, Kidambi, Usha, Egger, Linda A., McCauley, Ermenegilda, Van Riper, Gail, Mumford, Richard A., Schmidt, John A., Hagmann, William K.

“…A series of substituted tetrahydrofuroyl-1-phenylalanine derivatives was prepared and evaluated as VLA-4 antagonists. Substitution of the α carbon of the…”
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Triazolinone Biphenylsulfonamides as Angiotensin II Receptor Antagonists with High Affinity for Both the AT1 and AT2 Subtypes by Chang, Linda L, Ashton, Wallace T, Flanagan, Kelly L, Chen, Tsing-Bau, O'Malley, Stacey S, Zingaro, Gloria J, Siegl, Peter K. S, Kivlighn, Salah D, Lotti, Victor J

“…Angiotensin II (AII), the endogenous peptide ligand of the AII receptor, has equivalent high affinity for both the AT1 and AT2 receptor subtypes while most of…”
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Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles by Ashton, Wallace T, Cantone, Christine L, Chang, Linda L, Hutchins, Steven M, Strelitz, Robert A, MacCoss, Malcolm, Chang, Raymond S. L, Lotti, Victor J, Faust, Kristie A

“…By a variety of synthetic routes, we have synthesized a series of 3,4,5-trisubstituted 4H-1,2,4-triazoles and a related series of…”
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Phase I study of MEDI0639 in patients with advanced solid tumors by Falchook, Gerald Steven, Dowlati, Afshin, Naing, Aung, Gribbin, Matthew Joseph, Jenkins, David William, Chang, Linda L, Lai, Dominic W, Smith, David C.

“…Abstract only…”
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Triazolinone Biphenylsulfonamide Derivatives as Orally Active Angiotensin II Antagonists with Potent AT1 Receptor Affinity and Enhanced AT2 Affinity by Ashton, Wallace T, Chang, Linda L, Flanagan, Kelly L, Hutchins, Steven M, Naylor, Elizabeth M, Chakravarty, Prasun K, Patchett, Arthur A, Greenlee, William J, Chen, Tsing-Bau

“…Several series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones with acidic sulfonamide replacements of tetrazole at the 2'-position of the…”
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Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes by Chang, Linda L, Ashton, Wallace T, Flanagan, Kelly L, Chen, Tsing-Bau, O'Malley, Stacey S, Zingaro, Gloria J, Kivlighn, Salah D, Siegl, Peter K. S, Lotti, Victor J

“…In order to block the effects induced by the interactions between angiotensin II (AII) and both AT1 and AT2 receptors, we have pursued the discovery of orally…”
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Triazolinones as nonpeptide angiotensin II antagonists. 1. Synthesis and evaluation of potent 2,4,5-trisubstituted triazolinones by Chang, Linda L, Ashton, Wallace T, Flanagan, Kelly L, Strelitz, Robert A, MacCoss, Malcolm, Greenlee, William J, Chang, Raymond S. L, Lotti, Victor J, Faust, Kristie A

“…A series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones was prepared via several synthetic routes and evaluated as AII receptor antagonists in…”
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The discovery of small molecule carbamates as potent dual alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists by Chang, Linda L, Truong, Quang, Mumford, Richard A, Egger, Linda A, Kidambi, Usha, Lyons, Kathryn, McCauley, Ermengilda, Van Riper, Gail, Vincent, Stella, Schmidt, John A, MacCoss, Malcolm, Hagmann, William K

“…The alpha(4)beta(1) and alpha(4)beta(7) integrins are implicated in several inflammatory disease states. Systematic SAR studies of an alpha(4)beta(1)-specific…”
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Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1 by Pepinsky, R Blake, Mumford, Richard A, Chen, Ling Ling, Leone, Diane, Amo, Suzanne E, Riper, Gail Van, Whitty, Adrian, Dolinski, Brian, Lobb, Roy R, Dean, Dennis C, Chang, Linda L, Raab, Conrad E, Si, Qian, Hagmann, William K, Lingham, Russell B

“…Integrins alpha9beta1 and alpha4beta1 form a distinct structural class, but while alpha4beta1 has been subjected to extensive study, alpha9beta1 remains poorly…”
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