Search Results - "Chang, Karshing"

A phase 3 double-blind study of the addition of tocilizumab vs placebo to cyclosporin/methotrexate GVHD prophylaxis by Kennedy, Glen A., Tey, Siok-Keen, Buizen, Luke, Varelias, Antiopi, Gartlan, Kate H., Curley, Cameron, Olver, Stuart D., Chang, Karshing, Butler, Jason P., Misra, Ashish, Subramoniapillai, Elango, Morton, A. James, Durrant, Simon, Henden, Andrea S., Moore, John, Ritchie, David, Gottlieb, David, Cooney, Julian, Paul, Sanjoy K., Hill, Geoffrey R.

“…We determined the efficacy of tocilizumab (TCZ) in preventing grade 2-4 acute graft-versus-host disease (aGVHD) in patients with acute leukemia or…”
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IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling by Wilkinson, Andrew N., Chang, Karshing, Kuns, Rachel D., Henden, Andrea S., Minnie, Simone A., Ensbey, Kathleen S., Clouston, Andrew D., Zhang, Ping, Koyama, Motoko, Hidalgo, Juan, Rose-John, Stefan, Varelias, Antiopi, Vuckovic, Slavica, Gartlan, Kate H., Hill, Geoffrey R.

“…Graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (alloSCT) is characterized by interleukin-6 (IL-6) dysregulation. IL-6 can mediate…”
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Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract by Gartlan, Kate H., Koyama, Motoko, Lineburg, Katie E., Chang, Karshing, Ensbey, Kathleen S., Kuns, Rachel D., Henden, Andrea S., Samson, Luke D., Clouston, Andrew D., Lopez, Angel F., MacDonald, Kelli P.A., Hill, Geoffrey R.

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) has recently emerged as an important pathogenic cytokine in acute graft-versus-host disease (GVHD),…”
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A critical role for donor-derived IL-22 in cutaneous chronic GVHD by Gartlan, Kate H., Bommiasamy, Hemamalini, Paz, Katelyn, Wilkinson, Andrew N., Owen, Mary, Reichenbach, Dawn K., Banovic, Tatjana, Wehner, Kimberly, Buchanan, Faith, Varelias, Antiopi, Kuns, Rachel D., Chang, Karshing, Fedoriw, Yuri, Shea, Thomas, Coghill, James, Zaiken, Michael, Plank, Maximilian W., Foster, Paul S., Clouston, Andrew D., Blazar, Bruce R., Serody, Jonathan S., Hill, Geoffrey R.

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Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT by Gartlan, Kate H., Varelias, Antiopi, Koyama, Motoko, Robb, Renee J., Markey, Kate A., Chang, Karshing, Wilkinson, Andrew N., Smith, David, Ullah, Md Ashik, Kuns, Rachel D., Raffelt, Neil C., Olver, Stuart D., Lineburg, Katie E., Teal, Bianca E., Cheong, Melody, Teng, Michele W.L., Smyth, Mark J., Tey, Siok-Keen, MacDonald, Kelli P.A., Hill, Geoffrey R.

“…T-helper 17 (Th17) cells have been widely implicated as drivers of autoimmune disease. In particular, Th17 cytokine plasticity and acquisition of an…”
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IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease by Henden, Andrea S, Koyama, Motoko, Robb, Renee J, Forero, Adriana, Kuns, Rachel D, Chang, Karshing, Ensbey, Kathleen S, Varelias, Antiopi, Kazakoff, Stephen H, Waddell, Nicole, Clouston, Andrew D, Giri, Rabina, Begun, Jakob, Blazar, Bruce R, Degli-Esposti, Mariapia A, Kotenko, Sergei V, Lane, Steven W, Bowerman, Kate L, Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H, Hill, Geoffrey R

“…Immunopathology and intestinal stem cell (ISC) loss in the gastrointestinal (GI) tract is the prima facie manifestation of graft-versus-host disease (GVHD) and…”
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IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease by Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H., Hill, Geoffrey R.

“…Immunopathology and intestinal stem cell (ISC) loss in the gastrointestinal (GI) tract is the prima facie manifestation of graft-versus-host disease (GVHD) and…”
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Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR3 and TLR7/8 ligation by Pearson, Frances E, Chang, Karshing, Minoda, Yoshihito, Rojas, Ingrid M Leal, Haigh, Oscar L, Daraj, Ghazal, Tullett, Kirsteen M, Radford, Kristen J

“…Mice reconstituted with human hematopoietic stem cells are valuable models to study aspects of the human immune system in vivo. We describe a humanized mouse…”
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A critical role for donor‐derived IL‐22 in cutaneous chronic GVHD by Gartlan, Kate H., Bommiasamy, Hemamalini, Paz, Katelyn, Wilkinson, Andrew N., Owen, Mary, Reichenbach, Dawn K., Banovic, Tatjana, Wehner, Kimberly, Buchanan, Faith, Varelias, Antiopi, Kuns, Rachel D., Chang, Karshing, Fedoriw, Yuri, Shea, Thomas, Coghill, James, Zaiken, Michael, Plank, Maximilian W., Foster, Paul S., Clouston, Andrew D., Blazar, Bruce R., Serody, Jonathan S., Hill, Geoffrey R.

“…Graft‐versus‐host disease (GVHD) is the major cause of nonrelapse morbidity and mortality after allogeneic stem cell transplantation (allo‐SCT). Prevention and…”
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Diverse IL-6 signalling modalities drive pathogenic T cell differentiation and graft-versus-host-disease after allotransplantation by Gartlan, Kate H, Wilkinson, Andrew, Chang, Karshing, Kuns, Rachel D, Henden, Andrea, Minnie, Simone A, Ensbey, Kathleen S, Clouston, Andrew, Zhang, Ping, Koyama, Motoko, Hidalgo, Juan, Rose-John, Stefan, Varelias, Antiopi, Vuckovic, Slavica, Hill, Geoffrey R

“…Abstract Allogeneic stem cell transplantation (alloSCT) and graft-versus-host disease (GVHD) are characterized by systemic interleukin 6 (IL-6) dysregulation,…”
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Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo by Spicer, Julie A, Miller, Christian K, O’Connor, Patrick D, Jose, Jiney, Giddens, Anna C, Jaiswal, Jagdish K, Jamieson, Stephen M. F, Bull, Matthew R, Denny, William A, Akhlaghi, Hedieh, Trapani, Joseph A, Hill, Geoff R, Chang, Karshing, Gartlan, Kate H

“…Perforin is a key effector protein in the vertebrate immune system and is secreted by cytotoxic T lymphocytes and natural killer cells to help eliminate…”
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A Critical Role for Donor-Derived IL-22 in Cutaneous Chronic Gvhd by Gartlan, Kate H, Bommiasamy, Hemamalini, Paz, Katelyn, Wilkinson, Andrew, Owen, Mary, Reichenbach, Dawn, Banovic, Tatjana, Wehner, Kimberly, Buchanan, Faith, Varelias, Antiopi, Kuns, Rachel, Chang, Karshing, Fedoriw, Yuri, Shea, Thomas C., Coghill, James M., Zaiken, Michael, Plank, Maximilian, Foster, Paul, Clouston, Andrew, Blazar, Bruce, Serody, Jonathan S, Hill, Geoffrey R

“…Graft-versus-host disease (GVHD) is the major cause of non-relapse morbidity and mortality after allogeneic stem cell transplant (allo-SCT). Chronic cutaneous…”
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ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome by Cheong, Melody, Gartlan, Kate H, Lee, Jason S, Tey, Siok-Keen, Zhang, Ping, Kuns, Rachel D, Andoniou, Christopher E, Martins, Jose Paulo, Chang, Karshing, Sutton, Vivien R, Kelly, Greg, Varelias, Antiopi, Vuckovic, Slavica, Markey, Kate A, Boyle, Glen M, Smyth, Mark J, Engwerda, Christian R, MacDonald, Kelli P A, Trapani, Joseph A, Degli-Esposti, Mariapia A, Koyama, Motoko, Hill, Geoffrey R

“…The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, which is essential for innate…”
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Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors by Gartlan, Kate H., Jaiswal, Jagdish K., Bull, Matthew R., Akhlaghi, Hedieh, Sutton, Vivien R., Alexander, Kylie A., Chang, Karshing, Hill, Geoffrey R., Miller, Christian K., O’Connor, Patrick D., Jose, Jiney, Trapani, Joseph A., Charman, Susan A., Spicer, Julie A., Jamieson, Stephen M. F.

“…Perforin is a key effector of lymphocyte-mediated cell death pathways and contributes to transplant rejection of immunologically mismatched grafts. We have…”
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Interferon Lambda Protects Gastrointestinal Stem Cells from Acute Gvhd by Henden, Andrea S, Robb, Renee, Forero, Adriana, Kuns, Rachel D, Ensbey, Kathleen S, Chang, Karshing, Varelias, Antiopi, Kazakoff, Stephen H, Waddell, Nic, Clouston, Andrew D, Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A, Kotenko, Sergei V, Lane, Steven W, Bowerman, Kate L, Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H, Hill, Geoffrey

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