Search Results - "Chang, Jenny C."

A comprehensive overview of metaplastic breast cancer: clinical features and molecular aberrations by Reddy, Tejaswini P, Rosato, Roberto R, Li, Xiaoxian, Moulder, Stacy, Piwnica-Worms, Helen, Chang, Jenny C

“…Metaplastic breast cancer (MpBC) is an exceedingly rare breast cancer variant that is therapeutically challenging and aggressive. MpBC is defined by the…”
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Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer by Burstein, Matthew D, Tsimelzon, Anna, Poage, Graham M, Covington, Kyle R, Contreras, Alejandro, Fuqua, Suzanne A W, Savage, Michelle I, Osborne, C Kent, Hilsenbeck, Susan G, Chang, Jenny C, Mills, Gordon B, Lau, Ching C, Brown, Powel H

“…Genomic profiling studies suggest that triple-negative breast cancer (TNBC) is a heterogeneous disease. In this study, we sought to define TNBC subtypes and…”
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Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression by La Belle Flynn, Alyssa, Calhoun, Benjamin C., Sharma, Arishya, Chang, Jenny C., Almasan, Alexandru, Schiemann, William P.

“…Breast cancer stem cells (BCSCs) are unique in their ability to undergo unlimited self-renewal, an essential process in breast cancer recurrence following…”
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A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis by Yao, Fan, Deng, Yalan, Zhao, Yang, Mei, Ying, Zhang, Yilei, Liu, Xiaoguang, Martinez, Consuelo, Su, Xiaohua, Rosato, Roberto R., Teng, Hongqi, Hang, Qinglei, Yap, Shannon, Chen, Dahu, Wang, Yumeng, Chen, Mei-Ju May, Zhang, Mutian, Liang, Han, Xie, Dong, Chen, Xin, Zhu, Hao, Chang, Jenny C., You, M. James, Sun, Yutong, Gan, Boyi, Ma, Li

“…The growing knowledge of ferroptosis has suggested the role and therapeutic potential of ferroptosis in cancer, but has not been translated into effective…”
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Microenvironmental Regulation of Epithelial―Mesenchymal Transitions in Cancer by DINGCHENG GAO, VAHDAT, Linda T, WONG, Stephen, CHANG, Jenny C, MITTAL, Vivek

“…The evolution of the cancer cell into a metastatic entity is the major cause of death in patients with cancer. Activation of the epithelial-to-mesenchymal…”
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Molecular characterization of breast cancer CTCs associated with brain metastasis by Boral, Debasish, Vishnoi, Monika, Liu, Haowen N., Yin, Wei, Sprouse, Marc L., Scamardo, Antonio, Hong, David S., Tan, Tuan Z., Thiery, Jean P., Chang, Jenny C., Marchetti, Dario

“…The enumeration of EpCAM-positive circulating tumor cells (CTCs) has allowed estimation of overall metastatic burden in breast cancer patients. However, a…”
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Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts by Liu, Suling, Cong, Yang, Wang, Dong, Sun, Yu, Deng, Lu, Liu, Yajing, Martin-Trevino, Rachel, Shang, Li, McDermott, Sean P., Landis, Melissa D., Hong, Suhyung, Adams, April, D’Angelo, Rosemarie, Ginestier, Christophe, Charafe-Jauffret, Emmanuelle, Clouthier, Shawn G., Birnbaum, Daniel, Wong, Stephen T., Zhan, Ming, Chang, Jenny C., Wicha, Max S.

“…Previous studies have suggested that breast cancer stem cells (BCSCs) mediate metastasis, are resistant to radiation and chemotherapy, and contribute to…”
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Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models by Rosato, Roberto R, Dávila-González, Daniel, Choi, Dong Soon, Qian, Wei, Chen, Wen, Kozielski, Anthony J, Wong, Helen, Dave, Bhuvanesh, Chang, Jenny C

“…Breast cancer has been considered not highly immunogenic, and few patients benefit from current immunotherapies. However, new strategies are aimed at changing…”
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A window-of-opportunity trial of the CXCR1/2 inhibitor reparixin in operable HER-2-negative breast cancer by Goldstein, Lori J, Perez, Raymond P, Yardley, Denise, Han, Linda K, Reuben, James M, Gao, Hui, McCanna, Susan, Butler, Beth, Ruffini, Pier Adelchi, Liu, Yi, Rosato, Roberto R, Chang, Jenny C

“…Cancer stem cells (CSCs) are purported to be responsible for tumor initiation, treatment resistance, disease recurrence, and metastasis. CXCR1, one of the…”
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Epithelial-mesenchymal transition, cancer stem cells and treatment resistance by Dave, Bhuvanesh, Mittal, Vivek, Tan, Nicholas M, Chang, Jenny C

“…Breast cancer relapse, in a large number of patients, after initial response to standard of care therapy warrants development of novel therapies against…”
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Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma by Li, Zongwei, Liu, Huan, He, Jin, Wang, Zhiqiang, Yin, Zheng, You, Gichun, Wang, Zhiming, Davis, Richard E., Lin, Pei, Bergsagel, P. Leif, Manasanch, Elisabet E., Wong, Stephen T.C., Esnaola, Nestor F., Chang, Jenny C., Orlowski, Robert Z., Yi, Qing, Yang, Jing

“…Obesity is often linked to malignancies including multiple myeloma, and the underlying mechanisms remain elusive. Here we showed that acetyl-CoA synthetase 2…”
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Epithelial-Mesenchymal Transition (EMT) in Tumor-Initiating Cells and Its Clinical Implications in Breast Cancer by Creighton, Chad J, Chang, Jenny C, Rosen, Jeffrey M

“…There is increasing support for the hypothesis that most tumors contain a subpopulation of cells, referred to here as tumor initiating cells (TICs), with the…”
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Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1 by Yuan, Xiangliang, Duan, Yimin, Xiao, Yi, Sun, Kai, Qi, Yutao, Zhang, Yuan, Ahmed, Zamal, Moiani, Davide, Yao, Jun, Li, Hongzhong, Zhang, Lin, Yuzhalin, Arseniy E, Li, Ping, Zhang, Chenyu, Badu-Nkansah, Akosua, Saito, Yohei, Liu, Xianghua, Kuo, Wen-Ling, Ying, Haoqiang, Sun, Shao-Cong, Chang, Jenny C, Tainer, John A, Yu, Dihua

“…Despite the popular use of dietary supplements during conventional cancer treatments, their impacts on the efficacies of prevalent immunotherapies, including…”
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Multicenter Phase II Study of Neoadjuvant Lapatinib and Trastuzumab With Hormonal Therapy and Without Chemotherapy in Patients With Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer: TBCRC 006 by RIMAWI, Mothaffar F, MAYER, Ingrid A, SCHIFF, Rachel, KENT OSBORNE, C, CHANG, Jenny C, FORERO, Andres, NANDA, Rita, GOETZ, Matthew P, RODRIGUEZ, Angel A, PAVLICK, Anne C, TAO WANG, HILSENBECK, Susan G, GUTIERREZ, Carolina

“…We previously reported the eradication of human epidermal growth factor receptor 2 (HER2)- amplified human xenografts in mice by inhibition of the HER2 pathway…”
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Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer by Granados-Principal, Sergio, Liu, Yi, Guevara, Maria L, Blanco, Elvin, Choi, Dong Soon, Qian, Wei, Patel, Tejal, Rodriguez, Angel A, Cusimano, Joseph, Weiss, Heidi L, Zhao, Hong, Landis, Melissa D, Dave, Bhuvanesh, Gross, Steven S, Chang, Jenny C

“…Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) is…”
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Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features by Creighton, Chad J, Li, Xiaoxian, Landis, Melissa, Dixon, J. Michael, Neumeister, Veronique M, Sjolund, Ashley, Rimm, David L, Wong, Helen, Rodriguez, Angel, Herschkowitz, Jason I, Fan, Cheng, Zhang, Xiaomei, He, Xiaping, Pavlick, Anne, Gutierrez, M. Carolina, Renshaw, Lorna, Larionov, Alexey A, Faratian, Dana, Hilsenbeck, Susan G, Perou, Charles M, Lewis, Michael T, Rosen, Jeffrey M, Chang, Jenny C

“…Some breast cancers have been shown to contain a small fraction of cells characterized by CD44⁺/CD24⁻/low cell-surface antigen profile that have high…”
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Cancer stem cells: Role in tumor growth, recurrence, metastasis, and treatment resistance by Chang, Jenny C.

“…Cancer stem cells (CSCs) are a class of pluripotent cells that have been observed in most types of solid and hematologic cancers. CSCs have been shown in…”
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Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer by Dávila-González, Daniel, Choi, Dong Soon, Rosato, Roberto R, Granados-Principal, Sergio M, Kuhn, John G, Li, Wen-Feng, Qian, Wei, Chen, Wen, Kozielski, Anthony J, Wong, Helen, Dave, Bhuvanesh, Chang, Jenny C

“…Chemoresistance in triple-negative breast cancer (TNBC) is associated with the activation of a survival mechanism orchestrated by the endoplasmic reticulum…”
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Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival by den Hollander, Petra, Rawls, Kathryn, Tsimelzon, Anna, Shepherd, Jonathan, Mazumdar, Abhijit, Hill, Jamal, Fuqua, Suzanne A W, Chang, Jenny C, Osborne, C Kent, Hilsenbeck, Susan G, Mills, Gordon B, Brown, Powel H

“…Triple-negative breast cancer (TNBC) has the worst prognosis of all breast cancers, and women diagnosed with TNBC currently lack targeted treatment options. To…”
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The impact of nitric oxide on HER family post-translational modification and downstream signaling in cancer by O'Neill, Ciara E, Sun, Kai, Sundararaman, Sugunapriyadharshini, Chang, Jenny C, Glynn, Sharon A

“…The human epidermal growth factor receptor (HER) family consists of four members, activated by two families of ligands. They are known for mediating cell-cell…”
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