Search Results - "Chang, Jason C."

SMARCA4-Deficient Thoracic Sarcomatoid Tumors Represent Primarily Smoking-Related Undifferentiated Carcinomas Rather Than Primary Thoracic Sarcomas by Rekhtman, Natasha, Montecalvo, Joseph, Chang, Jason C, Alex, Deepu, Ptashkin, Ryan N, Ai, Ni, Sauter, Jennifer L, Kezlarian, Brie, Jungbluth, Achim, Desmeules, Patrice, Beras, Amanda, Bishop, Justin A, Plodkowski, Andrew J, Gounder, Mrinal M, Schoenfeld, Adam J, Namakydoust, Azadeh, Li, Bob T, Rudin, Charles M, Riely, Gregory J, Jones, David R, Ladanyi, Marc, Travis, William D

“…Highly aggressive thoracic neoplasms characterized by SMARCA4 (BRG1) deficiency and undifferentiated round cell or rhabdoid morphology have been recently…”
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Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes by Chang, Jason C, Offin, Michael, Falcon, Christina, Brown, David, Houck-Loomis, Brian R, Meng, Fanli, Rudneva, Vasilisa A, Won, Helen H, Amir, Sharon, Montecalvo, Joseph, Desmeules, Patrice, Kadota, Kyuichi, Adusumilli, Prasad S, Rusch, Valerie W, Teed, Sarah, Sabari, Joshua K, Benayed, Ryma, Nafa, Khedoudja, Borsu, Laetitia, Li, Bob T, Schram, Alison M, Arcila, Maria E, Travis, William D, Ladanyi, Marc, Drilon, Alexander, Rekhtman, Natasha

“…Invasive mucinous adenocarcinoma (IMA) is a unique subtype of lung adenocarcinoma, characterized genomically by frequent mutations or specific gene fusions,…”
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Invasive Mucinous Adenocarcinomas With Spatially Separate Lung Lesions: Analysis of Clonal Relationship by Comparative Molecular Profiling by Yang, Soo-Ryum, Chang, Jason C, Leduc, Charles, Tan, Kay See, Dogan, Snjezana, Benayed, Ryma, Borsu, Laetitia, Offin, Michael, Drilon, Alexander, Travis, William D, Arcila, Maria E, Ladanyi, Marc, Rekhtman, Natasha

“…Pulmonary invasive mucinous adenocarcinomas (IMAs) often present with spatially separate lung lesions. Clonal relationship between such lesions, particularly…”
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Lung-only melanoma: UV mutational signature supports origin from occult cutaneous primaries and argues against the concept of primary pulmonary melanoma by Yang, Chen, Sanchez-Vega, Francisco, Chang, Jason C., Chatila, Walid K., Shoushtari, Alexander N., Ladanyi, Marc, Travis, William D., Busam, Klaus J., Rekhtman, Natasha

“…Primary pulmonary melanoma (PPM) is an entity recognized by the thoracic WHO classification. However, given the absence of native melanocytes in the lung and…”
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Bronchiolar Adenoma/Pulmonary Ciliated Muconodular Papillary Tumor by Shirsat, Hemlata, Zhou, Fang, Chang, Jason C, Rekhtman, Natasha, Saqi, Anjali, Argyropoulos, Kimon, Azour, Lea, Simms, Anthony, Melamed, Jonathan, Hung, Yin P, Roden, Anja C, Mino-Kenudson, Mari, Moreira, Andre L, Narula, Navneet

“…Abstract Objectives To describe the histologic features that are helpful in the diagnosis of the rare bronchiolar adenomas/ciliated muconodular papillary…”
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Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies by Murciano-Goroff, Yonina R., Schram, Alison M., Rosen, Ezra Y., Won, Helen, Gong, Yixiao, Noronha, Anne Marie, Janjigian, Yelena Y., Stadler, Zsofia K., Chang, Jason C., Yang, Soo-Ryum, Mandelker, Diana, Offit, Kenneth, Berger, Michael F., Donoghue, Mark T. A., Bandlamudi, Chaitanya, Drilon, Alexander

“…The association between loss of BRCA1/2 and a homologous recombination deficiency phenotype is lineage dependent. In BRCA-associated cancers such as breast,…”
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Diagnosis of thoracic SMARCA4‐deficient undifferentiated tumor in cytology by Kezlarian, Brie, Montecalvo, Joseph, Bodd, Francis M., Chang, Jason C., Riedel, Elyn, White, Charlie, Rekhtman, Natasha, Sauter, Jennifer L.

“…Introduction Although alterations in SMARCA4‐deficient occur in non–small cell lung carcinoma (SD‐NSCLC), thoracic SMARCA4‐deficient undifferentiated tumor…”
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Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation by Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Zhan, Yingqian A, Hasan, Maysun M, Chavan, Shweta S, Meng, Fanli, Uddin, Fathema, Allaj, Viola, Manoj, Parvathy, Shah, Nisargbhai S, Chan, Joseph M, Ciampricotti, Metamia, Chow, Andrew, Offin, Michael, Ray-Kirton, Jordana, Egger, Jacklynn D, Bhanot, Umesh K, Linkov, Irina, Asher, Marina, Roehrl, Michael H, Ventura, Katia, Qiu, Juan, de Stanchina, Elisa, Chang, Jason C, Rekhtman, Natasha, Houck-Loomis, Brian, Koche, Richard P, Yu, Helena A, Sen, Triparna, Rudin, Charles M

“…Lineage plasticity, the ability to transdifferentiate among distinct phenotypic identities, facilitates therapeutic resistance in cancer. In lung…”
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A Pan-Cancer Study of Somatic TERT Promoter Mutations and Amplification in 30,773 Tumors Profiled by Clinical Genomic Sequencing by Gupta, Sounak, Vanderbilt, Chad M., Lin, Yun-Te, Benhamida, Jamal K., Jungbluth, Achim A., Rana, Satshil, Momeni-Boroujeni, Amir, Chang, Jason C., Mcfarlane, Tiffany, Salazar, Paulo, Mullaney, Kerry, Middha, Sumit, Zehir, Ahmet, Gopalan, Anuradha, Bale, Tejus A., Ganly, Ian, Arcila, Maria E., Benayed, Ryma, Berger, Michael F., Ladanyi, Marc, Dogan, Snjezana

“…TERT gene promoter mutations are known in multiple cancer types. Other TERT alterations remain poorly characterized. Sequencing data from 30,773 tumors…”
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Pathologic Assessment and Staging of Multiple Non–Small Cell Lung Carcinomas: A Paradigm Shift with the Emerging Role of Molecular Methods by Chang, Jason C., Rekhtman, Natasha

“…Non–small cell lung carcinomas (NSCLCs) commonly present as 2 or more separate tumors. Biologically, this encompasses 2 distinct processes: separate primary…”
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Proliferation centers in bone marrows involved by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): a clinicopathologic analysis by Chang, Jason C., M.D, Harrington, Alexandra M., M.D, Olteanu, Horatiu, M.D., Ph.D, VanTuinen, Peter, Ph.D, Kroft, Steven H., M.D

“…ABSTRACT OBJECTIVES Proliferation centers (PCs) are a characteristic finding in CLL/SLL lymph nodes, and their presence and extent in this site are not…”
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Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR -Mutant Lung Cancer by Schoenfeld, Adam J, Chan, Joseph M, Kubota, Daisuke, Sato, Hiroki, Rizvi, Hira, Daneshbod, Yahya, Chang, Jason C, Paik, Paul K, Offin, Michael, Arcila, Maria E, Davare, Monika A, Shinde, Ujwal, Pe'er, Dana, Rekhtman, Natasha, Kris, Mark G, Somwar, Romel, Riely, Gregory J, Ladanyi, Marc, Yu, Helena A

“…Patterns of resistance to first-line osimertinib are not well-established and have primarily been evaluated using plasma assays, which cannot detect histologic…”
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A cutaneous epithelioid vascular tumor harboring a TPM3::ALK fusion by Linos, Konstantinos, Chang, Jason C., Busam, Klaus J.

“…Substantial progress has been made in understanding the molecular pathways associated with vascular tumors over the last two decades. In addition to mutations…”
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Lobectomy Is Associated with Better Outcomes than Sublobar Resection in Spread through Air Spaces (STAS)-Positive T1 Lung Adenocarcinoma: A Propensity Score-Matched Analysis by Eguchi, Takashi, Kameda, Koji, Lu, Shaohua, Bott, Matthew J, Tan, Kay See, Montecalvo, Joseph, Chang, Jason C, Rekhtman, Natasha, Jones, David R, Travis, William D, Adusumilli, Prasad S

“…Spread through air spaces (STAS) is a form of invasion wherein tumor cells extend beyond the tumor edge within the lung parenchyma. In lung adenocarcinoma…”
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Bronchiolar Adenoma: Expansion of the Concept of Ciliated Muconodular Papillary Tumors With Proposal for Revised Terminology Based on Morphologic, Immunophenotypic, and Genomic Analysis of 25 Cases by Chang, Jason C, Montecalvo, Joseph, Borsu, Laetitia, Lu, Shaohua, Larsen, Brandon T, Wallace, William Dean, Sae-Ow, Wichit, Mackinnon, Alexander C, Kim, Hyunjae R, Bowman, Anita, Sauter, Jennifer L, Arcila, Maria E, Ladanyi, Marc, Travis, William D, Rekhtman, Natasha

“…We have identified 25 lesions involving alveolar lung parenchyma characterized by nodular proliferation of bland bilayered bronchiolar-type epithelium…”
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Insights into pathogenesis of fatal COVID‐19 pneumonia from histopathology with immunohistochemical and viral RNA studies by Sauter, Jennifer L, Baine, Marina K, Butnor, Kelly J, Buonocore, Darren J, Chang, Jason C, Jungbluth, Achim A, Szabolcs, Matthias J, Morjaria, Sejal, Mount, Sharon L, Rekhtman, Natasha, Selbs, Elena, Sheng, Zong‐Mei, Xiao, Yongli, Kleiner, David E, Pittaluga, Stefania, Taubenberger, Jeffery K, Rapkiewicz, Amy V, Travis, William D

“…Introduction We describe post‐mortem pulmonary histopathologic findings of COVID‐19 pneumonia in patients with a spectrum of disease course, from rapid demise…”
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Comprehensive Next-Generation Sequencing Unambiguously Distinguishes Separate Primary Lung Carcinomas From Intrapulmonary Metastases: Comparison with Standard Histopathologic Approach by Chang, Jason C, Alex, Deepu, Bott, Matthew, Tan, Kay See, Seshan, Venkatraman, Golden, Andrew, Sauter, Jennifer L, Buonocore, Darren J, Vanderbilt, Chad M, Gupta, Sounak, Desmeules, Patrice, Bodd, Francis M, Riely, Gregory J, Rusch, Valerie W, Jones, David R, Arcila, Maria E, Travis, William D, Ladanyi, Marc, Rekhtman, Natasha

“…In patients with >1 non-small cell lung carcinoma (NSCLC), the distinction between separate primary lung carcinomas (SPLCs) and intrapulmonary metastases…”
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Cellular Cutaneous Epithelioid Hemangioma Harboring the Rare GATA6::FOXO1 Gene Fusion by Tepp, Jonathan A, Agaram, Narasimhan P, Chang, Jason C, Linos, Konstantinos

“…Epithelioid hemangioma (EH) is a benign vascular tumor displaying diverse histomorphologies. Among these, one EH subtype comprises cellular sheets of atypical…”
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Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS by Rose Brannon, A., Jayakumaran, Gowtham, Diosdado, Monica, Patel, Juber, Razumova, Anna, Hu, Yu, Meng, Fanli, Haque, Mohammad, Sadowska, Justyna, Murphy, Brian J., Baldi, Tessara, Johnson, Ian, Ptashkin, Ryan, Hasan, Maysun, Srinivasan, Preethi, Rema, Anoop Balakrishnan, Rijo, Ivelise, Agarunov, Aaron, Won, Helen, Perera, Dilmi, Brown, David N., Samoila, Aliaksandra, Jing, Xiaohong, Gedvilaite, Erika, Yang, Julie L., Stephens, Dennis P., Dix, Jenna-Marie, DeGroat, Nicole, Nafa, Khedoudja, Syed, Aijazuddin, Li, Alan, Lebow, Emily S., Bowman, Anita S., Ferguson, Donna C., Liu, Ying, Mata, Douglas A., Sharma, Rohit, Yang, Soo-Ryum, Bale, Tejus, Benhamida, Jamal K., Chang, Jason C., Dogan, Snjezana, Hameed, Meera R., Hechtman, Jaclyn F., Moung, Christine, Ross, Dara S., Vakiani, Efsevia, Vanderbilt, Chad M., Yao, JinJuan, Razavi, Pedram, Smyth, Lillian M., Chandarlapaty, Sarat, Iyer, Gopa, Abida, Wassim, Harding, James J., Krantz, Benjamin, O’Reilly, Eileen, Yu, Helena A., Li, Bob T., Rudin, Charles M., Diaz, Luis, Solit, David B., Arcila, Maria E., Ladanyi, Marc, Loomis, Brian, Tsui, Dana, Berger, Michael F., Zehir, Ahmet, Benayed, Ryma

“…Circulating cell-free DNA from blood plasma of cancer patients can be used to non-invasively interrogate somatic tumor alterations. Here we develop MSK-ACCESS…”
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Rb Tumor Suppressor in Small Cell Lung Cancer: Combined Genomic and IHC Analysis with a Description of a Distinct Rb-Proficient Subset by Febres-Aldana, Christopher A, Chang, Jason C, Ptashkin, Ryan, Wang, Yuhan, Gedvilaite, Erika, Baine, Marina K, Travis, William D, Ventura, Katia, Bodd, Francis, Yu, Helena A, Quintanal-Villalonga, Alvaro, Lai, W Victoria, Egger, Jacklynn V, Offin, Michael, Ladanyi, Marc, Rudin, Charles M, Rekhtman, Natasha

“…RB1 mutations and loss of retinoblastoma (Rb) expression represent consistent but not entirely invariable hallmarks of small cell lung cancer (SCLC). The…”
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