Search Results - "Chang, Hui Hua"

FDA-Approved and Emerging Next Generation Predictive Biomarkers for Immune Checkpoint Inhibitors in Cancer Patients by Wang, Ye, Tong, Zhuang, Zhang, Wenhua, Zhang, Weizhen, Buzdin, Anton, Mu, Xiaofeng, Yan, Qing, Zhao, Xiaowen, Chang, Hui-Hua, Duhon, Mark, Zhou, Xin, Zhao, Gexin, Chen, Hong, Li, Xinmin

“…A patient's response to immune checkpoint inhibitors (ICIs) is a complex quantitative trait, and determined by multiple intrinsic and extrinsic factors. Three…”
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Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice by Hao, Fang, Xu, Qinhong, Wang, Jing, Yu, Shuo, Chang, Hui-Hua, Sinnett-Smith, James, Eibl, Guido, Rozengurt, Enrique

“…We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic…”
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Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice by Chang, Hui-Hua, Moro, Aune, Takakura, Kazuki, Su, Hsin-Yuan, Mo, Allen, Nakanishi, Masako, Waldron, Richard T, French, Samuel W, Dawson, David W, Hines, O Joe, Li, Gang, Go, Vay Liang W, Sinnett-Smith, James, Pandol, Stephen J, Lugea, Aurelia, Gukovskaya, Anna S, Duff, Michael O, Rosenberg, Daniel W, Rozengurt, Enrique, Eibl, Guido

“…Epidemiologic data has linked obesity to a higher risk of pancreatic cancer, but the underlying mechanisms are poorly understood. To allow for detailed…”
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Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model by Chang, Hui-Hua, Moro, Aune, Chou, Caroline Ei Ne, Dawson, David W., French, Samuel, Schmidt, Andrea I., Sinnett-Smith, James, Hao, Fang, Hines, O. Joe, Eibl, Guido, Rozengurt, Enrique

“…Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus…”
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Obesity-Induced Adipose Tissue Inflammation as a Strong Promotional Factor for Pancreatic Ductal Adenocarcinoma by Chang, Hui-Hua, Eibl, Guido

“…Pancreatic ductal adenocarcinoma (PDAC) is expected to soon become the second leading cause of cancer related deaths in the United States. This may be due to…”
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Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice by Xu, Mu, Chang, Hui-Hua, Jung, Xiaoman, Moro, Aune, Chou, Caroline Ei Ne, King, Jonathan, Hines, O Joe, Sinnett-Smith, James, Rozengurt, Enrique, Eibl, Guido

“…Hormone sensitive lipase (HSL) is a neutral lipase that preferentially catalyzes the hydrolysis of diacylglycerol contributing to triacylglycerol breakdown in…”
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Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells by Yang, Jiayue, Waldron, Richard T, Su, Hsin-Yuan, Moro, Aune, Chang, Hui-Hua, Eibl, Guido, Ferreri, Kevin, Kandeel, Fouad R, Lugea, Aurelia, Li, Ling, Pandol, Stephen J

“…Epidemiological studies support strong links between obesity, diabetes, and pancreatic disorders including pancreatitis and pancreatic adenocarcinoma (PDAC)…”
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Suppression of Gingival NK Cells in Precancerous and Cancerous Stages of Pancreatic Cancer in KC and BLT-Humanized Mice by Kaur, Kawaljit, Chang, Hui-Hua, Cook, Jessica, Eibl, Guido, Jewett, Anahid

“…The aim of our studies is to determine the dynamics of natural killer (NK) cell modulation in gingivae in precancerous and cancerous stages of pancreatic and…”
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Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice by Kaur, Kawaljit, Chang, Hui-Hua, Topchyan, Paytsar, Cook, Jessica Morgan, Barkhordarian, Andre, Eibl, Guido, Jewett, Anahid

“…The combined/synergistic effect of genetic mutation of KRAS in the pancreas and obesity, a life-style factor on suppression of natural killer (NK) cells at the…”
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Upregulated Matrisomal Proteins and Extracellular Matrix Mechanosignaling Underlie Obesity-Associated Promotion of Pancreatic Ductal Adenocarcinoma by Waldron, Richard T, Lugea, Aurelia, Chang, Hui-Hua, Su, Hsin-Yuan, Quiros, Crystal, Lewis, Michael S, Che, Mingtian, Ramanujan, V Krishnan, Rozengurt, Enrique, Eibl, Guido, Pandol, Stephen J

“…Diet-induced obesity (DIO) promotes pancreatic ductal adenocarcinoma (PDAC) in mice expressing KRasG12D in the pancreas (KC mice), but the precise mechanisms…”
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Robust Early Inflammation of the Peripancreatic Visceral Adipose Tissue During Diet-Induced Obesity in the KrasG12D Model of Pancreatic Cancer by Hertzer, Kathleen M, Xu, Mu, Moro, Aune, Dawson, David W, Du, Lin, Li, Gang, Chang, Hui-Hua, Stark, Alexander P, Jung, Xiaoman, Hines, Oscar Joe, Eibl, Guido

“…Obesity increases the incidence of multiple types of cancer. Our previous work has shown that a high-fat, high-calorie diet (HFCD) leads to visceral obesity,…”
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Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism by Schmidt, Andrea, MD, Sinnett-Smith, James, BSc, Young, Steven, PhD, Chang, Hui-Hua, PhD, Hines, O. Joe, MD, Dawson, David W., MD, Rozengurt, Enrique, PhD, Eibl, Guido, MD

“…Background There is strong evidence linking inflammation and the development of pancreatic ductal adenocarcinoma. Cyclooxygenase-2 (COX-2) and COX-2-derived…”
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E-cadherin expression in obesity-associated, Kras-initiated pancreatic ductal adenocarcinoma in mice by Stark, Alexander P., MD, Chang, Hui-Hua, PhD, Jung, Xiaoman, MD, Moro, Aune, MS, Hertzer, Kathleen, MD, PhD, Xu, Mu, MD, PhD, Schmidt, Andrea, MD, Hines, O. Joe, MD, Eibl, Guido, MD

“…Background The epithelial-mesenchymal transition (EMT) is critical in the development of invasive epithelial malignancies. EMT is accelerated by inflammation…”
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The prevalence of metabolic syndrome in drug-naïve bipolar II disorder patients before and after twelve week pharmacological intervention by Hung Chi, Mei, Hua Chang, Hui, Tzeng, Nian-Sheng, Huang, San-Yuan, Chou, Kuei-Ru, Chun Tsai, Hsin, Kuang Yang, Yen, Lu, Ru-Band, See Chen, Po

“…Abstract Background Accumulating evidence indicates a high prevalence rate of metabolic disturbance in bipolar disorder (BP) patients. However, the prevalence…”
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Insulin-Like Growth Factor–1 Preserves Salivary Gland Function After Fractionated Radiation by Limesand, Kirsten H., Ph.D, Avila, Jennifer L., M.S, Victory, Kerton, Chang, Hui-Hua, Shin, Yoon Joo, Grundmann, Oliver, Ph.D, Klein, Rob R., M.D

“…Purpose Radiotherapy for head-and-neck cancer consists of fractionated radiation treatments that cause significant damage to salivary glands leading to chronic…”
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Metformin alters the duodenal microbiome and decreases the incidence of pancreatic ductal adenocarcinoma promoted by diet-induced obesity by Dong, Tien S, Chang, Hui-Hua, Hauer, Meg, Lagishetty, Venu, Katzka, William, Rozengurt, Enrique, Jacobs, Jonathan P, Eibl, Guido

“…Pancreatic ductal adenocarcinoma (PDAC)'s growing incidence has been linked to the rise in obesity and type 2 diabetes mellitus. In previous work, we have…”
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A Longitudinal Study of the Association between the LEPR Polymorphism and Treatment Response in Patients with Bipolar Disorder by Chang, Hui Hua, Hsueh, Yuan-Shuo, Cheng, Yung Wen, Tseng, Huai-Hsuan

“…Patients with bipolar disorder (BD) exhibit individual variability in the treatment outcome, and genetic background could contribute to BD itself and the…”
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Identification and development of mPGES-1 inhibitors: where we are at? by Chang, Hui-Hua, Meuillet, Emmanuelle J

“…Microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal synthase responsible for the synthesis of the pro-tumorigenic prostaglandin E(2) (PGE(2))…”
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Associations of leptin and corticostriatal connectivity in bipolar disorder by Wei, Shyh-Yuh, Tseng, Huai-Hsuan, Chang, Hui Hua, Chang, Wei Hung, Yang, Yen Kuang, Chen, Po See

“…Bipolar disorder (BD) and metabolic disturbance represent a chronic state of low-grade inflammation and corticostriatal circuitry alterations. Herein, we aimed…”
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Increased leptin-b expression and metalloprotease expression contributed to the pyridoxine-associated toxicity in zebrafish larvae displaying seizure-like behavior by Chen, Po-Yuan, Tsai, Yi-Wen, Chang, Alice YW, Chang, Hui-Hua, Hsiao, Ya-Hsin, Huang, Chin-Wei, Sung, Pi-Shan, Chen, Bing-Hung, Fu, Tzu-Fun

“…[Display omitted] Epilepsy is a common neurological disorder affecting people of all ages, races and ethnic backgrounds world-wide. Vitamin B6 supplementation…”
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