Search Results - "Chang, Esther H"

Phase I Study of a Systemically Delivered p53 Nanoparticle in Advanced Solid Tumors by Senzer, Neil, Nemunaitis, John, Nemunaitis, Derek, Bedell, Cynthia, Edelman, Gerald, Barve, Minal, Nunan, Robert, Pirollo, Kathleen F, Rait, Antonina, Chang, Esther H

“…Selective delivery of therapeutic molecules to primary and metastatic tumors is optimal for effective cancer therapy. A liposomal nanodelivery complex (scL)…”
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Integrated Genomic and Functional microRNA Analysis Identifies miR-30-5p as a Tumor Suppressor and Potential Therapeutic Nanomedicine in Head and Neck Cancer by Saleh, Anthony D, Cheng, Hui, Martin, Scott E, Si, Han, Ormanoglu, Pinar, Carlson, Sophie, Clavijo, Paul E, Yang, Xinping, Das, Rita, Cornelius, Shaleeka, Couper, Jamie, Chepeha, Douglas, Danilova, Ludmila, Harris, Thomas M, Prystowsky, Michael B, Childs, Geoffrey J, Smith, Richard V, Robertson, A Gordon, Jones, Steven J M, Cherniack, Andrew D, Kim, Sang S, Rait, Antonina, Pirollo, Kathleen F, Chang, Esther H, Chen, Zhong, Van Waes, Carter

“…To identify deregulated and inhibitory miRNAs and generate novel mimics for replacement nanomedicine for head and neck squamous cell carcinomas (HNSCC). We…”
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TP53 Gene Therapy as a Potential Treatment for Patients with COVID-19 by Harford, Joe B, Kim, Sang Soo, Pirollo, Kathleen F, Chang, Esther H

“…SGT-53 is a novel investigational agent that comprises an immunoliposome carrying a plasmid vector driving expression of the human gene that encodes wild-type…”
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scL-2PAM: A Novel Countermeasure That Ameliorates Neuroinflammation and Neuronal Losses in Mice Exposed to an Anticholinesterase Organophosphate by Moghe, Manish, Kim, Sang-Soo, Guan, Miaoyin, Rait, Antonina, Pirollo, Kathleen F, Harford, Joe B, Chang, Esther H

“…Due to their inhibition of acetylcholinesterase, organophosphates are among the most toxic of chemicals. Pralidoxime (a.k.a 2-PAM) is the only…”
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Combination with SGT-53 overcomes tumor resistance to a checkpoint inhibitor by Kim, Sang-Soo, Harford, Joe B., Moghe, Manish, Rait, Antonina, Chang, Esther H.

“…The tumor suppressor p53 responds to genotoxic and oncogenic stresses by inducing cell cycle arrest and apoptosis. Recent studies suggest that p53 also…”
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A Phase l Study of a Tumor-targeted Systemic Nanodelivery System, SGT-94, in Genitourinary Cancers by Siefker-Radtke, Arlene, Zhang, Xin-qiao, Guo, Charles C, Shen, Yu, Pirollo, Kathleen F, Sabir, Sharjeel, Leung, Chris, Leong-Wu, Cindy, Ling, Chi-Ming, Chang, Esther H, Millikan, Randall E, Benedict, William F

“…Gene therapy development has been limited by our inability to target multifocal cancer with systemic delivery. We developed a systemically administered,…”
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The Clinical Potential of Targeted Nanomedicine: Delivering to Cancer Stem-like Cells by Kim, Sang-Soo, Rait, Antonina, Rubab, Farwah, Rao, Abhi K, Kiritsy, Michael C, Pirollo, Kathleen F, Wang, Shangzi, Weiner, Louis M, Chang, Esther H

“…Cancer stem-like cells (CSCs) have been implicated in recurrence and treatment resistance in many human cancers. Thus, a CSC-targeted drug delivery strategy to…”
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Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system by PIROLLO, Kathleen F, RAIT, Antonina, QI ZHOU, SUNG HEE HWANG, DAGATA, John A, ZON, Gerald, HOGREFE, Richard I, PALCHIK, Guillermo, CHANG, Esther H

“…The field of small interfering RNA (siRNA) as potent sequence-selective inhibitors of transcription is rapidly developing. However, until now, low transfection…”
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A Novel P53 Nanomedicine Reduces Immunosuppression and Augments Anti-PD-1 Therapy for Non-Small Cell Lung Cancer in Syngeneic Mouse Models by Kim, Sang-Soo, Harford, Joe B, Moghe, Manish, Doherty, Caroline, Chang, Esther H

“…Lung cancer is among the most common and lethal cancers and warrants novel therapeutic approaches to improving patient outcomes. Although immune checkpoint…”
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Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms by Moore, Ellen C., Sun, Lillian, Clavijo, Paul E., Friedman, Jay, Harford, Joe B., Saleh, Anthony D., Van Waes, Carter, Chang, Esther H., Allen, Clint T.

“…Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic…”
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A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival in a mouse model of glioblastoma multiforme by Kim, Sang-Soo, PhD, Rait, Antonina, PhD, Kim, Eric, BSc, Pirollo, Kathleen F., PhD, Chang, Esther H., PhD

“…Abstract Development of temozolomide (TMZ) resistance contributes to the poor prognosis for glioblastoma multiforme (GBM) patients. It was previously…”
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Tumor-Targeting Nanocomplex Delivery of Novel Tumor Suppressor RB94 Chemosensitizes Bladder Carcinoma Cells In vitro and In vivo by Pirollo, Kathleen F, Rait, Antonina, Zhou, Qi, Zhang, Xin-qiao, Zhou, Jain, Kim, Chang-Soo, Benedict, William F, Chang, Esther H

“…Purpose: RB94, a truncated form of RB110, has enhanced tumor suppressor potency and activity against all tumor types tested to date including bladder…”
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Nanoimmunoliposome delivery of superparamagnetic iron oxide markedly enhances targeting and uptake in human cancer cells in vitro and in vivo by Yang, Chengli, PhD, Rait, Antonina, PhD, Pirollo, Kathleen F., PhD, Dagata, John A., PhD, Farkas, Natalia, PhD, Chang, Esther H., PhD

“…Abstract To circumvent the problem of reduction of the supermagnetic properties of superparamagnetic iron oxide (SPIO) nanoparticles after chemical…”
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Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide by Kim, Sang-Soo, Harford, Joe B, Moghe, Manish, Rait, Antonina, Pirollo, Kathleen F, Chang, Esther H

“…Abstract Intrinsic therapeutic resistance especially in cancer stem cells (CSCs) together with extensive tumor cell infiltration and restricted permeation of…”
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Effective treatment of glioblastoma requires crossing the blood–brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine by Kim, Sang-Soo, Harford, Joe B., Pirollo, Kathleen F., Chang, Esther H.

“…Glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor. Both therapeutic resistance and restricted permeation of drugs across the…”
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Antisense therapeutics: from theory to clinical practice by Pirollo, Kathleen F, Rait, Antonina, Sleer, Leanne S, Chang, Esther H

“…The use of antisense (AS) oligonucleotides as therapeutic agents was proposed as far back as the 1960s/1970s when the AS strategy was initially developed…”
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Safety and Efficacy in Advanced Solid Tumors of a Targeted Nanocomplex Carrying the p53 Gene Used in Combination with Docetaxel: A Phase 1b Study by Pirollo, Kathleen F, Nemunaitis, John, Leung, Po Ki, Nunan, Robert, Adams, Jana, Chang, Esther H

“…Loss of p53 suppressor function, through mutations or inactivation of the p53 pathway, occurs in most human cancers. SGT-53 is a liposomal nanocomplex designed…”
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Antisense oligonucleotides targeted to the human α folate receptor inhibit breast cancer cell growth and sensitize the cells to doxorubicin treatment by Jhaveri, Mona S, Rait, Antonina S, Chung, Koong-Nah, Trepel, Jane B, Chang, Esther H

“…Folates are essential for cell survival and are required for numerous biochemical processes. The human α isoform folate receptor (αhFR) has a very high…”
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Encapsulation of temozolomide in a tumor-targeting nanocomplex enhances anti-cancer efficacy and reduces toxicity in a mouse model of glioblastoma by Kim, Sang-Soo, Rait, Antonina, Kim, Eric, DeMarco, James, Pirollo, Kathleen F, Chang, Esther H

“…Highlights • GBM is the most aggressive and lethal type of brain tumor with a poor prognosis. • Novel strategies are needed to improve limited efficacy of TMZ…”
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Nanomedicine: Past, present and future – A global perspective by Chang, Esther H., Harford, Joe B., Eaton, Michael A.W., Boisseau, Patrick M., Dube, Admire, Hayeshi, Rose, Swai, Hulda, Lee, Dong Soo

“…Nanomedicine is an emerging and rapidly evolving field and includes the use of nanoparticles for diagnosis and therapy of a variety of diseases, as well as in…”
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