Search Results - "Chang, Donald C."

Regulation of somatic cell reprogramming through inducible mir-302 expression by Lin, Shi-Lung, Chang, Donald C, Lin, Chun-Hung, Ying, Shao-Yao, Leu, Davey, Wu, David T.S

“…Global demethylation is required for early zygote development to establish stem cell pluripotency, yet our findings reiterate this epigenetic reprogramming…”
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MicroRNA miR-302 Inhibits the Tumorigenecity of Human Pluripotent Stem Cells by Coordinate Suppression of the CDK2 and CDK4/6 Cell Cycle Pathways by LIN, Shi-Lung, CHANG, Donald C, YING, Shao-Yao, LEU, Davey, WU, David T. S

“…miR-302 is the major microRNA found in human embryonic stem cells and induced pluripotent stem cells, but its function has been unclear. In mice, there is…”
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Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis by Zhou, Liying, Chang, Donald C

“…Bax and Bak are known to play a central role in facilitating the release of mitochondrial intermembrane proteins during apoptosis. The detailed mechanism,…”
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The mechanism of using NMR for cancer detection by Chang, Donald C.

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Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis by Chen, Ye-Guang, Wang, Qiang, Lin, Shi-Lung, Chang, C Donald, Chuang, Jody, Chung, Jody, Ying, Shao-Yao

“…Activins, cytokine members of the transforming growth factor-beta superfamily, have various effects on many physiological processes, including cell…”
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Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest by Zhou, Lingli, Chan, W.K., Xu, Naihan, Xiao, Kang, Luo, Houwei, Luo, Kathy Qian, Chang, Donald C.

“…Tanshinone IIA (Tan IIA) is a compound isolated from Salvia miltiorrhiza Bunge (Danshen). The aim of this study is to investigate the mechanisms of its…”
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Using a micro electroporation chip to determine the optimal physical parameters in the uptake of biomolecules in HeLa cells by He, Huiqi, Chang, Donald C., Lee, Yi-Kuen

“…In this study, a new micro electroporation (EP) cell chip with three-dimensional (3D) electrodes was fabricated by means of MEMS technology, and tested on…”
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Degradation of Cyclin B Is Required for the Onset of Anaphase in Mammalian Cells by Chang, Donald C., Xu, Naihan, Luo, Kathy Q.

“…Recently, it has been shown that cyclin B1 was degraded mainly before the onset of anaphase in mammalian cells. When a nondegradable form of cyclin B1 was…”
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SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail by Yin, Yinliang, Yu, Vivian C., Zhu, Guang, Chang, Donald C.

“…We report evidence suggesting that methyltransferase SET8 plays a novel role in regulating cell cycle by suppressing DNA replication through histone binding…”
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Minocycline prevents glutamate‐induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways by Pi, Rongbiao, Li, Wenming, Lee, Nelson T. K., Chan, Hugh H. N., Pu, Yongmei, Chan, Ling Nga, Sucher, Nikolaus J., Chang, Donald C., Li, Mingtao, Han, Yifan

“…Minocycline has been shown to have remarkably neuroprotective qualities, but underlying mechanisms remain elusive. We reported here the robust neuroprotection…”
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Different Thresholds of MPF Inactivation are Responsible for Controlling Different Mitotic Events in Mammalian Cell Division by Xu, Naihan, Chang, Donald C.

“…We present evidence for a paradigm that, during cell division, the decreasing activity of MPF acts as a master signal, which utilizes different thresholds to…”
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Novel Dimeric Acetylcholinesterase Inhibitor Bis(7)-tacrine, but Not Donepezil, Prevents Glutamate-induced Neuronal Apoptosis by Blocking N-Methyl-d-aspartate Receptors by Li, Wenming, Pi, Rongbiao, Chan, Hugh H.N., Fu, Hongjun, Lee, Nelson T.K., Tsang, Hing Wai, Pu, Yongmei, Chang, Donald C., Li, Chaoying, Luo, Jialie, Xiong, Keming, Li, Zhiwang, Xue, Hong, Carlier, Paul R., Pang, Yuanping, Tsim, Karl W.K., Li, Mingtao, Han, Yifan

“…The neuroprotective properties of bis(7)-tacrine, a novel dimeric acetylcholinesterase (AChE) inhibitor, on glutamate-induced excitotoxicity were investigated…”
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Bioassay guided discovery of apoptosis inducers from gamboge by high-speed counter-current chromatography and high-pressure liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry by Han, Quan-Bin, Zhou, Yan, Feng, Chao, Xu, Gang, Huang, Sheng-Xiong, Li, Song-Lin, Qiao, Chun-Feng, Song, Jing-Zheng, Chang, Donald C., Luo, Kathy Q., Xu, Hong-Xi

“…A screening system, composed of high-speed counter-current chromatography and high-pressure liquid chromatography/electrospray ionization quadrupole…”
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Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells by Gao, W, Pu, Y, Luo, K Q, Chang, D C

“…During apoptosis, cytochrome c is released from mitochondria to the cytosol to activate a caspase cascade, which commits the cell to the death process. It has…”
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A quantum mechanical interpretation of gravitational redshift of electromagnetic wave by Chang, Donald C.

“…It had been observed that electro-magnetic waves can undergo a frequency shift in a gravitational field. This effect is important for satellite communication…”
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The MicroRNA by Ying, Shao-Yao, Chang, Donald C, Lin, Shi-Lung

“…MicroRNAs (miRNAs), widely distributed, small regulatory RNA genes, target both messenger RNA (mRNA) degradation and suppression of protein translation based…”
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Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state by Lin, Shi-Lung, Chang, Donald C, Chang-Lin, Samantha, Lin, Chun-Hung, Wu, David T S, Chen, David T, Ying, Shao-Yao

“…Renewal of stem cells differs from cancer cell growth in self-controlled cell division. The mir-302 microRNA (miRNA) family (mir-302s) is expressed most…”
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Polyprenylated Xanthones from Garcinia lancilimba Showing Apoptotic Effects against HeLa-C3 Cells by Han, Quan-Bing, Tian, Hong-Lei, Yang, Nian-Yun, Qiao, Chun-Feng, Song, Jing-Zheng, Chang, Donald C., Luo, Kathy Q., Xu, Hong-Xi

“…Three new prenylated xanthones, 1–3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated…”
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Mitochondrial Proteomic Analysis and Characterization of the Intracellular Mechanisms of Bis(7)-tacrine in Protecting against Glutamate-Induced Excitotoxicity in Primary Cultured Neurons by Fu, Hongjun, Li, Wenming, Liu, Yulin, Lao, Yuanzhi, Liu, Wei, Chen, Cheng, Yu, Hua, Lee, Nelson T. K, Chang, Donald C, Li, Peng, Pang, Yuanping, Tsim, Karl W. K, Li, Mingtao, Han, Yifan

“…Increasing evidence supports that the mitochondrial dysfunction, mainly caused by abnormal changes in mitochondrial proteins, plays a pivotal role in…”
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The MicroRNA (miRNA): Overview of the RNA Genes that Modulate Gene Function by Ying, Shao-Yao, Chang, Donald C., Lin, Shi-Lung

“…MicroRNAs (miRNAs), widely distributed, small regulatory RNA genes, target both messenger RNA (mRNA) degradation and suppression of protein translation based…”
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