Search Results - "Chang, Chuan‐Fa"
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Enterovirus A71 Containing Codon-Deoptimized VP1 and High-Fidelity Polymerase as Next-Generation Vaccine Candidate
Published in Journal of virology (01-07-2019)“…Enterovirus A71 (EV-A71) is a major pathogen that causes hand-foot-and-mouth disease (HFMD), which occasionally results in severe neurological complications…”
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2
Cell surface nucleolin facilitates enterovirus 71 binding and infection
Published in Journal of virology (01-04-2015)“…Because the pathogenesis of enterovirus 71 (EV71) remains mostly ambiguous, identifying the factors that mediate viral binding and entry to host cells is…”
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3
Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer
Published in Proceedings of the National Academy of Sciences - PNAS (26-02-2019)“…The globo-series glycosphingolipids (GSLs) SSEA3, SSEA4, and Globo-H specifically expressed on cancer cells are found to correlate with tumor progression and…”
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4
Detection of adulterated drugs in traditional Chinese medicine and dietary supplements using hydrogen as a carrier gas
Published in PloS one (10-10-2018)“…Helium, a minor component of natural gas and radioactive minerals, is most commonly used as a carrier in gas chromatography-mass spectrometry (GC-MS). Its…”
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Increased APOE glycosylation plays a key role in the atherogenicity of L5 low‐density lipoprotein
Published in The FASEB journal (01-07-2020)“…Low‐density lipoprotein (LDL) is heterogeneous, composed of particles with variable atherogenicity. Electronegative L5 LDL exhibits atherogenic properties in…”
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Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells
Published in Proceedings of the National Academy of Sciences - PNAS (26-01-2016)“…The discovery of cancer stem cells (CSCs), which are responsible for self-renewal and tumor growth in heterogeneous cancer tissues, has stimulated interests in…”
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Leukocyte cell‐derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment
Published in Hepatology (Baltimore, Md.) (01-03-2014)“…Leukocyte cell‐derived chemotoxin 2 (LECT2) has been shown to act as a tumor suppressor in hepatocellular carcinoma (HCC). However, the underlying mechanism…”
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Glycan-binding preferences and genetic evolution of human seasonal influenza A(H3N2) viruses during 1999-2007 in Taiwan
Published in PloS one (10-05-2018)“…It is generally agreed that human influenza virus preferentially binds to α-2,6-linked sialic acid-containing receptors, and mutations that change the binding…”
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9
Serum N-glycome characterization and anti-carbohydrate antibody profiling in oral squamous cell carcinoma patients
Published in PloS one (08-06-2017)“…Glycosylation is a protein post translational modification which plays important role in protein function, stabilization, trafficking, and turnover. Alteration…”
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Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via β-catenin/GSK-3β modulation in colorectal carcinoma
Published in PloS one (26-11-2013)“…Multidrug resistance (MDR), an unfavorable factor compromising the treatment efficacy of anticancer drugs, involves the upregulation of ATP binding cassette…”
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Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response
Published in Blood (01-11-2008)“…Thrombomodulin (TM), a widely expressing glycoprotein originally identified in vascular endothelium, is an important cofactor in the protein C anticoagulant…”
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12
Glycoproteomic identification of novel plasma biomarkers for oral cancer
Published in Yàowu shi͡p︡in fenxi (01-04-2019)“…Oral cancer with high incidence rates is occurring in many countries including in India, Pakistan, Bangladesh, Sri Lanka and Taiwan. Smoking, alcoholism, and…”
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13
Carbohydrate Ligands for COVID-19 Spike Proteins
Published in Viruses (06-02-2022)“…An outbreak of SARS-CoV-2 coronavirus (COVID-19) first detected in Wuhan, China, has created a public health emergency all over the world. The pandemic has…”
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The interaction Between Carbohydrates and the Antimicrobial Peptide P-113Tri is Involved in the Killing of Candida albicans
Published in Microorganisms (Basel) (21-02-2020)“…The emergence of drug resistance to is problematic in the clinical setting. Therefore, developing new antifungal drugs is in high demand. Our previous work…”
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Monocytic thrombomodulin promotes cell adhesion through interacting with its ligand, Lewis y
Published in Immunology and cell biology (01-04-2017)“…The leukocyte adhesion cascade involves multiple events that efficiently localize circulating leukocytes into the injured sites to mediate inflammatory…”
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Cell surface sialylation affects binding of enterovirus 71 to rhabdomyosarcoma and neuroblastoma cells
Published in BMC microbiology (01-08-2012)“…Enterovirus 71 (EV71) is a major causative agent of hand-foot-and-mouth disease (HFMD), and infection of EV71 to central nerve system (CNS) may result in a…”
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17
Derivation of Cinnamon Blocks Leukocyte Attachment by Interacting with Sialosides
Published in PloS one (15-06-2015)“…Molecules derived from cinnamon have demonstrated diverse pharmacological activities against infectious pathogens, diabetes and inflammatory diseases. This…”
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Toll-Like Receptor 3 Is Involved in Detection of Enterovirus A71 Infection and Targeted by Viral 2A Protease
Published in Viruses (05-12-2018)“…Enterovirus A71 (EV-A71) has emerged as a major pathogen causing hand, foot, and mouth disease, as well as neurological disorders. The host immune response…”
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Suppression of interleukin-6 increases enterovirus A71 lethality in mice
Published in Journal of biomedical science (12-12-2017)“…Enterovirus A71 (EV-A71) infection can induce fatal encephalitis in young children. Clinical reports show that interleukin-6 (IL-6) levels in the serum and…”
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Identification of novel tumor markers for oral squamous cell carcinoma using glycoproteomic analysis
Published in Clinica chimica acta (01-05-2013)“…Oral cancer, the largest subset of head and neck cancer, has become one of the most lethal malignancies during the last two decades. Although several…”
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