Search Results - "Chang, ChiehYing J"

Small Molecule Reversible Inhibitors of Bruton’s Tyrosine Kinase (BTK): Structure–Activity Relationships Leading to the Identification of 7‑(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]‑9H‑carbazole-1-carboxamide (BMS-935177) by De Lucca, George V, Shi, Qing, Liu, Qingjie, Batt, Douglas G, Beaudoin Bertrand, Myra, Rampulla, Rick, Mathur, Arvind, Discenza, Lorell, D’Arienzo, Celia, Dai, Jun, Obermeier, Mary, Vickery, Rodney, Zhang, Yingru, Yang, Zheng, Marathe, Punit, Tebben, Andrew J, Muckelbauer, Jodi K, Chang, ChiehYing J, Zhang, Huiping, Gillooly, Kathleen, Taylor, Tracy, Pattoli, Mark A, Skala, Stacey, Kukral, Daniel W, McIntyre, Kim W, Salter-Cid, Luisa, Fura, Aberra, Burke, James R, Barrish, Joel C, Carter, Percy H, Tino, Joseph A

“…Bruton’s tyrosine kinase (BTK) belongs to the TEC family of nonreceptor tyrosine kinases and plays a critical role in multiple cell types responsible for…”
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The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor by Kiefer, Susan E., Chang, ChiehYing J., Kimura, S. Roy, Gao, Mian, Xie, Dianlin, Zhang, Yaqun, Zhang, Guifen, Gill, Martin B., Mastalerz, Harold, Thompson, Lorin A., Cacace, Angela M., Sheriff, Steven

“…Tau‐tubulin kinase 1 (TTBK1) is a dual‐specificity (serine/threonine and tyrosine) kinase belonging to the casein kinase 1 superfamily. TTBK1 is a…”
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Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold by DODD, Dharmpal S, SHERIFF, Steven, MCKINNON, Murray, BARRISH, Joel C, SUCHARD, Suzanne J, MURALI DHAR, T. G, CHANGE, Chiehying J, STETSKO, Dawn K, PHILLIPS, Linda M, YINGRU ZHANG, LAUNAY, Michele, POTIN, Dominique, VACCARO, Wayne, POSS, Michael A

“…A new class of lymphocyte function-associated antigen-1 (LFA-1) antagonists is described. Elaboration of the 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold…”
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De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold by Potin, Dominique, Launay, Michele, Nicolai, Eric, Fabreguette, Maud, Malabre, Patrice, Caussade, François, Besse, Dominique, Skala, Stacey, Stetsko, Dawn K., Todderud, Gordon, Beno, Brett R., Cheney, Daniel L., Chang, Chiehying J., Sheriff, Steven, Hollenbaugh, Diane L., Barrish, Joel C., Iwanowicz, Edwin J., Suchard, Suzanne J., Dhar, T.G. Murali

“…LFA-1 is a member of the β2-integrin family and is expressed on all leukocytes. This paper describes the de novo design, synthesis, and in vitro activity of…”
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Small Molecule Reversible Inhibitors of Bruton’s Tyrosine Kinase (BTK): Structure–Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9 H -carbazole-1-carboxamide (BMS-935177) by De Lucca, George V., Shi, Qing, Liu, Qingjie, Batt, Douglas G., Beaudoin Bertrand, Myra, Rampulla, Rick, Mathur, Arvind, Discenza, Lorell, D’Arienzo, Celia, Dai, Jun, Obermeier, Mary, Vickery, Rodney, Zhang, Yingru, Yang, Zheng, Marathe, Punit, Tebben, Andrew J., Muckelbauer, Jodi K., Chang, ChiehYing J., Zhang, Huiping, Gillooly, Kathleen, Taylor, Tracy, Pattoli, Mark A., Skala, Stacey, Kukral, Daniel W., McIntyre, Kim W., Salter-Cid, Luisa, Fura, Aberra, Burke, James R., Barrish, Joel C., Carter, Percy H., Tino, Joseph A.

“…Bruton’s tyrosine kinase (BTK) belongs to the TEC family of nonreceptor tyrosine kinases and plays a critical role in multiple cell types responsible for…”
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Design of LFA-1 antagonists based on a 2,3-dihydro-1 H-pyrrolizin-5(7aH)-one scaffold by Dodd, Dharmpal S., Sheriff, Steven, Chang, ChiehYing J., Stetsko, Dawn K., Phillips, Linda M., Zhang, Yingru, Launay, Michele, Potin, Dominique, Vaccaro, Wayne, Poss, Michael A., McKinnon, Murray, Barrish, Joel C., Suchard, Suzanne J., Murali Dhar, T.G.

“…A new class of lymphocyte function-associated antigen-1 (LFA-1) antagonists is described. Elaboration of the 2,3-dihydro-1 H-pyrrolizin-5(7aH)-one scaffold…”
Get full text