Search Results - "Chang, C Hong"

Circulating markers of angiogenesis and endotheliopathy in COVID-19 by Pine, Alexander B., Meizlish, Matthew L., Goshua, George, Chang, C-Hong, Zhang, Hanming, Bishai, Jason, Bahel, Parveen, Patel, Amisha, Gbyli, Rana, Kwan, Jennifer M., Won, Christine H., Price, Christina, Dela Cruz, Charles S., Halene, Stephanie, van Dijk, David, Hwa, John, Lee, Alfred I., Chun, Hyung J.

“…Increase in thrombotic and microvascular complications is emerging to be a key feature of patients with critical illness associated with COVID-19 infection…”
Get full text

In developing mouse kidneys, orientation of loop of Henle growth is adaptive and guided by long‐range cues from medullary collecting ducts by Chang, C‐Hong, Davies, Jamie A.

“…The path taken by the loop of Henle, from renal cortex to medulla and back, is critical to the ability of the kidney to concentrate urine and recover water…”
Get full text

A neutrophil activation signature predicts critical illness and mortality in COVID-19 by Meizlish, Matthew L., Pine, Alexander B., Bishai, Jason D., Goshua, George, Nadelmann, Emily R., Simonov, Michael, Chang, C-Hong, Zhang, Hanming, Shallow, Marcus, Bahel, Parveen, Owusu, Kent, Yamamoto, Yu, Arora, Tanima, Atri, Deepak S., Patel, Amisha, Gbyli, Rana, Kwan, Jennifer, Won, Christine H., Dela Cruz, Charles, Price, Christina, Koff, Jonathan, King, Brett A., Rinder, Henry M., Wilson, F. Perry, Hwa, John, Halene, Stephanie, Damsky, William, van Dijk, David, Lee, Alfred I., Chun, Hyung J.

“…Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-19, but the mechanisms involved remain poorly understood. We…”
Get full text

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

“…Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2 infection. However, it remains to be determined whether increased complement…”
Get more information

Engineering kidneys from simple cell suspensions: an exercise in self-organization by Davies, Jamie A., Chang, C-Hong

“…Increasing numbers of people approaching and living with end-stage renal disease and failure of the supply of transplantable kidneys to keep pace has created…”
Get full text

Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by Induced Pluripotent Stem Cell Modeling by Kiskin, Fedir N, Chang, C-Hong, Huang, Christopher J Z, Kwieder, Baraa, Cheung, Christine, Dunmore, Benjamin J, Serrano, Felipe, Sinha, Sanjay, Morrell, Nicholas W, Rana, Amer A

“…[...]other phenotypes such as inner mitochondrial membrane (IMM) hyperpolarization could not be recapitulated. [...]there is a need to better understand the…”
Get full text

Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron by Lindström, Nils O, Lawrence, Melanie L, Burn, Sally F, Johansson, Jeanette A, Bakker, Elvira R M, Ridgway, Rachel A, Chang, C-Hong, Karolak, Michele J, Oxburgh, Leif, Headon, Denis J, Sansom, Owen J, Smits, Ron, Davies, Jamie A, Hohenstein, Peter

“…The different segments of the nephron and glomerulus in the kidney balance the processes of water homeostasis, solute recovery, blood filtration, and…”
Get full text

Node retraction during patterning of the urinary collecting duct system by Lindström, Nils O., Chang, C.‐Hong, Valerius, M. Todd, Hohenstein, Peter, Davies, Jamie A.

“…This report presents a novel mechanism for remodelling a branched epithelial tree. The mouse renal collecting duct develops by growth and repeated branching of…”
Get full text

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study by Goshua, George, Pine, Alexander B, Meizlish, Matthew L, Chang, C-Hong, Zhang, Hanming, Bahel, Parveen, Baluha, Audrey, Bar, Noffar, Bona, Robert D, Burns, Adrienne J, Dela Cruz, Charles S, Dumont, Anne, Halene, Stephanie, Hwa, John, Koff, Jonathan, Menninger, Hope, Neparidze, Natalia, Price, Christina, Siner, Jonathan M, Tormey, Christopher, Rinder, Henry M, Chun, Hyung J, Lee, Alfred I

“…An important feature of severe acute respiratory syndrome coronavirus 2 pathogenesis is COVID-19-associated coagulopathy, characterised by increased thrombotic…”
Get full text

BMPR1A promotes ID2–ZEB1 interaction to suppress excessive endothelial to mesenchymal transition by Lee, Heon-Woo, Adachi, Takaomi, Pak, Boryeong, Park, Saejeong, Hu, Xiaoyue, Choi, Woosoung, Kowalski, Piotr S, Chang, C Hong, Clapham, Katharine R, Lee, Aram, Papangeli, Irinna, Kim, Jongmin, Han, Orjin, Park, Jihwan, Anderson, Daniel G, Simons, Michael, Jin, Suk-Won, Chun, Hyung J

“…Abstract Aims Components of bone morphogenetic protein (BMP) signalling have been implicated in both pathogenesis of pulmonary arterial hypertension (PAH) and…”
Get full text

Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys by Lawrence, Melanie L., Chang, C-Hong, Davies, Jamie A.

“…Recent advances in renal tissue engineering have shown that dissociated, early renogenic tissue from the developing embryo can self-assemble into…”
Get full text

A self-avoidance mechanism in patterning of the urinary collecting duct tree by Davies, Jamie A, Hohenstein, Peter, Chang, C-Hong, Berry, Rachel

“…Glandular organs require the development of a correctly patterned epithelial tree. These arise by iterative branching: early branches have a stereotyped…”
Get full text

An improved method of renal tissue engineering, by combining renal dissociation and reaggregation with a low-volume culture technique, results in development of engineered kidneys complete with loops of Henle by Chang, C-Hong, Davies, Jamie A

“…Tissue engineering of functional kidney tissue is an important goal for clinical restoration of renal function in patients damaged by infectious,…”
Get more information

Clinically compatible advances in blood-derived endothelial progenitor cell isolation and reprogramming for translational applications by Eminli, Sarah, Kwieder, Baraa, Yi, Kevin, Huang, Christopher J.Z., Moon, Jung-Il, Chang, C-Hong, Kiskin, Fedir N., Morrell, Nicholas W., Hamilton, Brad, Rana, Amer A.

“…•Clinically-compatible advances in EPC isolation and reprogramming.•Reduced blood-sampling volumes from 80 mL to 10 mL allowing wider use of EPCs.•Unlike other…”
Get full text

Complement Activation Is Associated with Endothelial Damage in Hematopoietic Stem Cell Transplant Associated-Thrombotic Microangiopathy by Jacobi, Paula M, Cofiell, Roxanne, Chang, C-Hong, Kim, SungKwon, Sartain, Sarah E

Get full text

Delayed production of neutralizing antibodies correlates with fatal COVID-19 by Lucas, Carolina, Klein, Jon, Sundaram, Maria E., Liu, Feimei, Wong, Patrick, Silva, Julio, Mao, Tianyang, Oh, Ji Eun, Mohanty, Subhasis, Huang, Jiefang, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Israelow, Benjamin, Vogels, Chantal B. F., Muenker, M. Catherine, Chang, C-Hong, Casanovas-Massana, Arnau, Moore, Adam J., Zell, Joseph, Fournier, John B., Wyllie, Anne L., Campbell, Melissa, Lee, Alfred I., Chun, Hyung J., Grubaugh, Nathan D., Schulz, Wade L., Farhadian, Shelli, Dela Cruz, Charles, Ring, Aaron M., Shaw, Albert C., Wisnewski, Adam V., Yildirim, Inci, Ko, Albert I., Omer, Saad B., Iwasaki, Akiko

“…Recent studies have provided insights into innate and adaptive immune dynamics in coronavirus disease 2019 (COVID-19). However, the exact features of antibody…”
Get full text

Abstract 4139399: Targeting Hepatic Complement C3 Attenuates Pulmonary Arterial Hypertension Phenotype in Rodents by Keles, Merve, Arnold, Nadine, West, Laura, Turton, Helena, Kim, Sung-Kwon, Lasaro, Melissa, Rammanujam, Meera, Chang, C-Hong, Wilkins, M, Lawrie, Allan

“…Abstract only Background: Pulmonary arterial hypertension (PAH) is a severe condition characterized by pulmonary vascular remodelling leading to right…”
Get full text

Plasma Proteomic Profiling Illustrates Endothelial and Complement Signature in Patients with Alcohol-Associated Cirrhosis by Allen, Cecily, Butt, Ayesha, Zhao, Xiwen, Li, Fangyong, Bahel, Parveen, Chang, C-Hong, Chun, Hyung, Gu, Sean, Hwa, John, Jakab, Sofia, Chen, Bonnie, Garcia-Tsao, Guadalupe, Rinder, Henry, To, Uyen, McConnell, Matthew, Lee, Alfred I, Pine, Alexander

Get full text

PRO-THROMBOTIC SIGNATURE FROM NEUTROPHIL ACTIVATION AND DECREASED ADAMTS13 TO VWF RATIO IS A KEY DRIVER OF CARDIAC INJURY IN HOSPITALIZED PATIENTS WITH COVID-19 by Wang, Stephen Yishu, Pine, Alexander B., Mankbadi, Michael, Chang, C. Hong, Madeeva, Daria, Zhang, Hanming, Dajani, Abdel R.B., Crandall, Ian, Sugeng, Lissa, Lee, Alfred I., Chun, Hyung

Get full text

Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19 by Lucas, Carolina, Klein, Jon, Sundaram, Maria E., Liu, Feimei, Wong, Patrick, Silva, Julio, Mao, Tianyang, Oh, Ji Eun, Mohanty, Subhasis, Huang, Jiefang, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Israelow, Benjamin, Vogels, Chantal B. F., Muenker, M. Catherine, Chang, C-Hong, Casanovas-Massana, Arnau, Moore, Adam J., Zell, Joseph, Fournier, John B., Wyllie, Anne L., Campbell, Melissa, Lee, Alfred I., Chun, Hyung J., Grubaugh, Nathan D., Schulz, Wade L., Farhadian, Shelli, Dela Cruz, Charles, Ring, Aaron M., Shaw, Albert C., Wisnewski, Adam V., Yildirim, Inci, Ko, Albert I., Omer, Saad B., Iwasaki, Akiko

Get full text