Search Results - "Chang, Bill C. H."

Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation by Stroehlein, Andreas J, Korhonen, Pasi K, Lee, V Vern, Ralph, Stuart A, Mentink-Kane, Margaret, You, Hong, McManus, Donald P, Tchuenté, Louis-Albert Tchuem, Stothard, J Russell, Kaur, Parwinder, Dudchenko, Olga, Aiden, Erez Lieberman, Yang, Bicheng, Yang, Huanming, Emery, Aidan M, Webster, Bonnie L, Brindley, Paul J, Rollinson, David, Chang, Bill C H, Gasser, Robin B, Young, Neil D

“…Urogenital schistosomiasis is caused by the blood fluke Schistosoma haematobium and is one of the most neglected tropical diseases worldwide, afflicting > 100…”
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Expanded complement of Niemann-Pick type C2-like protein genes in Clonorchis sinensis suggests functions beyond sterol binding and transport by Anari, Marziyeh, Stroehlein, Andreas J, Hall, Ross S, Chang, Bill C H, Gasser, Robin B, Young, Neil D

“…The parasitic flatworm Clonorchis sinensis inhabits the biliary tree of humans and other piscivorous mammals. This parasite can survive and thrive in the bile…”
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Comparative bioinformatic analysis suggests that specific dauer-like signalling pathway components regulate Toxocara canis development and migration in the mammalian host by Ma, Guangxu, Wang, Tao, Korhonen, Pasi K, Nie, Shuai, Reid, Gavin E, Stroehlein, Andreas J, Koehler, Anson V, Chang, Bill C H, Hofmann, Andreas, Young, Neil D, Gasser, Robin B

“…Toxocara canis is quite closely related to Ascaris suum but its biology is more complex, involving a phase of arrested development (diapause or hypobiosis) in…”
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Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus by Jiao, Yaqing, Preston, Sarah, Koehler, Anson V, Stroehlein, Andreas J, Chang, Bill C H, Simpson, Kaylene J, Cowley, Karla J, Palmer, Michael J, Laleu, Benoît, Wells, Timothy N C, Jabbar, Abdul, Gasser, Robin B

“…In partnership with the Medicines for Malaria Venture (MMV), we screened a collection ('Stasis Box') of 400 compounds (which have been in clinical development…”
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Phylogenomic and biogeographic reconstruction of the Trichinella complex by Korhonen, Pasi K., Pozio, Edoardo, La Rosa, Giuseppe, Chang, Bill C. H., Koehler, Anson V., Hoberg, Eric P., Boag, Peter R., Tan, Patrick, Jex, Aaron R., Hofmann, Andreas, Sternberg, Paul W., Young, Neil D., Gasser, Robin B.

“…Trichinellosis is a globally important food-borne parasitic disease of humans caused by roundworms of the Trichinella complex. Extensive biological diversity…”
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Enhanced Genomic and Transcriptomic Resources for Trichinella pseudospiralis and T. spiralis to Underpin the Discovery of Molecular Differences between Stages and Species by Korhonen, Pasi K, La Rosa, Giuseppe, Sumanam, Sunita B, Gomez Morales, Maria Angeles, Ludovisi, Alessandra, Pozio, Edoardo, Tonanzi, Daniele, Chang, Bill C H, Young, Neil D, Gasser, Robin B

“…Nematodes of the genus are important pathogens of humans and animals. This study aimed to enhance the genomic and transcriptomic resources for…”
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Inference of Essential Genes of the Parasite Haemonchus contortus via Machine Learning by Campos, Túlio L, Korhonen, Pasi K, Young, Neil D, Wang, Tao, Song, Jiangning, Marhoefer, Richard, Chang, Bill C H, Selzer, Paul M, Gasser, Robin B

“…Over the years, comprehensive explorations of the model organisms (elegant worm) and (vinegar fly) have contributed substantially to our understanding of…”
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Structure–Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development by Le, Thuy G, Kundu, Abhijit, Ghoshal, Atanu, Nguyen, Nghi H, Preston, Sarah, Jiao, Yaqing, Ruan, Banfeng, Xue, Lian, Huang, Fei, Keiser, Jennifer, Hofmann, Andreas, Chang, Bill C. H, Garcia-Bustos, Jose, Wells, Timothy N. C, Palmer, Michael J, Jabbar, Abdul, Gasser, Robin B, Baell, Jonathan B

“…Recently, we have discovered that the registered pesticide, tolfenpyrad, unexpectedly and potently inhibits the development of the L4 larval stage of the…”
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High Throughput Screening of the NatureBank 'Marine Collection' in a Haemonchus Bioassay Identifies Anthelmintic Activity in Extracts from a Range of Sponges from Australian Waters by Taki, Aya C, Byrne, Joseph J, Jabbar, Abdul, Lum, Kah Yean, Hayes, Sasha, Addison, Russell S, Ramage, Kelsey S, Hofmann, Andreas, Ekins, Merrick G, Wang, Tao, Chang, Bill C H, Davis, Rohan A, Gasser, Robin B

“…Widespread resistance in parasitic nematodes to most classes of anthelmintic drugs demands the discovery and development of novel compounds with distinct…”
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Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain by Preston, Sarah, Korhonen, Pasi K., Mouchiroud, Laurent, Cornaglia, Matteo, McGee, Sean L., Young, Neil D., Davis, Rohan A., Crawford, Simon, Nowell, Cameron, Ansell, Brendan R. E., Fisher, Gillian M., Andrews, Katherine T., Chang, Bill C. H., Gijs, Martin A. M., Sternberg, Paul W., Auwerx, Johan, Baell, Jonathan, Hofmann, Andreas, Jabbar, Abdul, Gasser, Robin B.

“…ABSTRACT As a result of limited classes of anthelmintics and an over‐reliance on chemical control, there is a great need to discover new compounds to combat…”
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Three Small Molecule Entities (MPK18, MPK334 and YAK308) with Activity against Haemonchus contortus In Vitro by Taki, Aya C., Jabbar, Abdul, Kurz, Thomas, Lungerich, Beate, Ma, Guangxu, Byrne, Joseph J., Pflieger, Marc, Asfaha, Yodita, Fischer, Fabian, Chang, Bill C. H., Sleebs, Brad E., Gasser, Robin B.

“…Due to widespread multi-drug resistance in parasitic nematodes of livestock animals, there is an urgent need to discover new anthelmintics with distinct…”
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Identification of Fromiamycalin and Halaminol A from Australian Marine Sponge Extracts with Anthelmintic Activity against Haemonchus contortus by Herath, H M P Dilrukshi, Preston, Sarah, Jabbar, Abdul, Garcia-Bustos, Jose, Taki, Aya C, Addison, Russell S, Hayes, Sasha, Beattie, Karren D, McGee, Sean L, Martin, Sheree D, Ekins, Merrick G, Hooper, John N A, Chang, Bill C H, Hofmann, Andreas, Davis, Rohan A, Gasser, Robin B

“…There is an urgent need to discover and develop new anthelmintics for the treatment of parasitic nematodes of veterinary importance to circumvent challenges…”
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Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868 by Taki, Aya C., Wang, Tao, Nguyen, Nghi N., Ang, Ching-Seng, Leeming, Michael G., Nie, Shuai, Byrne, Joseph J., Young, Neil D., Zheng, Yuanting, Ma, Guangxu, Korhonen, Pasi K., Koehler, Anson V., Williamson, Nicholas A., Hofmann, Andreas, Chang, Bill C. H., Häberli, Cécile, Keiser, Jennifer, Jabbar, Abdul, Sleebs, Brad E., Gasser, Robin B.

“…Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. The control of these parasites…”
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High-Throughput Phenotypic Assay to Screen for Anthelmintic Activity on Haemonchus contortus by Taki, Aya C., Byrne, Joseph J., Wang, Tao, Sleebs, Brad E., Nguyen, Nghi, Hall, Ross S., Korhonen, Pasi K., Chang, Bill C.H., Jackson, Paul, Jabbar, Abdul, Gasser, Robin B.

“…Parasitic worms cause very significant diseases in animals and humans worldwide, and their control is critical to enhance health, well-being and productivity…”
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Natural Compounds from the Marine Brown Alga Caulocystis cephalornithos with Potent In Vitro-Activity against the Parasitic Nematode Haemonchus contortus by Taki, Aya C., Brkljača, Robert, Wang, Tao, Koehler, Anson V., Ma, Guangxu, Danne, Jill, Ellis, Sarah, Hofmann, Andreas, Chang, Bill C. H., Jabbar, Abdul, Urban, Sylvia, Gasser, Robin B.

“…Eight secondary metabolites (1 to 8) were isolated from a marine sponge, a marine alga and three terrestrial plants collected in Australia and subsequently…”
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Mitochondrial genomes of Trichinella species and genotypes – a basis for diagnosis, and systematic and epidemiological explorations by Mohandas, Namitha, Pozio, Edoardo, La Rosa, Giuseppe, Korhonen, Pasi K., Young, Neil D., Koehler, Anson V., Hall, Ross S., Sternberg, Paul W., Boag, Peter R., Jex, Aaron R., Chang, Bill C.H., Gasser, Robin B.

“…[Display omitted] •Deep sequencing of 15 mitochondrial (mt) genomes of Trichinella is reported.•The systematic relationships among taxa (T1–T12) were…”
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Synthetic Kavalactone Analogues with Increased Potency and Selective Anthelmintic Activity against Larvae of Haemonchus contortus In Vitro by Herath, H M P Dilrukshi, Taki, Aya C, Nguyen, Nghi, Garcia-Bustos, José, Hofmann, Andreas, Wang, Tao, Ma, Guangxu, Chang, Bill C H, Jabbar, Abdul, Sleebs, Brad E, Gasser, Robin B

“…Kava extract, an aqueous rhizome emulsion of the plant , has been used for centuries by Pacific Islanders as a ceremonial beverage, and has been sold as an…”
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Human toxocariasis – A look at a neglected disease through an epidemiological ‘prism’ by Rostami, Ali, Ma, Guangxu, Wang, Tao, Koehler, Anson V., Hofmann, Andreas, Chang, Bill C.H., Macpherson, Calum N., Gasser, Robin B.

“…Toxocariasis, a disease caused by infection with larvae of Toxocara canis, T. cati and/or congeners, represents clinical syndromes in humans including visceral…”
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Analyses of Compact Trichinella Kinomes Reveal a MOS-Like Protein Kinase with a Unique N-Terminal Domain by Stroehlein, Andreas J, Young, Neil D, Korhonen, Pasi K, Chang, Bill C H, Sternberg, Paul W, La Rosa, Giuseppe, Pozio, Edoardo, Gasser, Robin B

“…Parasitic worms of the genus Trichinella (phylum Nematoda; class Enoplea) represent a complex of at least twelve taxa that infect a range of different host…”
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Gene functionality's influence on the second codon: A large-scale survey of second codon composition in three domains by Tang, Sen-Lin, Chang, Bill C.H., Halgamuge, Saman K.

“…The second codon of a transcript, besides encoding for an amino acid, is now known to also have multiple molecular functions and is involved in translation…”
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