Search Results - "Chandu, Ala"

Filamin A Regulates Cardiovascular Remodeling by Bandaru, Sashidar, Ala, Chandu, Zhou, Alex-Xianghua, Akyürek, Levent M.

“…Filamin A (FLNA) is a large actin-binding cytoskeletal protein that is important for cell motility by stabilizing actin networks and integrating them with cell…”
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A critical review of therapeutic interventions in sickle cell disease: Progress and challenges by Ala, Chandu, Joshi, Renuka Parshuram, Gupta, Pragya, Goswami, Sangam Giri, Ramalingam, Sivaprakash, Kondapalli Venkata Gowri, Chandra Sekhar, Sankaranarayanan, Murugesan

“…Sickle cell disease (SCD) is an autosomal recessive genetic disorder that occurs due to the point mutation in the β‐globin gene, which results in the formation…”
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Retrospective Review of Chromane Analogues as Anti-protozoal Leads: A Decade's Worth of Evolution by Jadhav, Snehal Rajkumar, Karan Kumar, Banoth, Joshi, Renuka Parshuram, Suryakant, Chougule Kishor, Chandu, Ala, Muzaffar-Ur-Rehman, Mohammed, Khetmalis, Yogesh Mahadu, Nandikolla, Adinarayana, Murugesan, Sankaranarayan, Chandra Sekhar, Kondapalli Venkata Gowri

“…Tropical, vector-borne, and neglected diseases with a limited number of medication therapies include Leishmaniasis, Malaria, Chagas and Human African…”
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The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway by Gul, Nadia, Karlsson, Joakim, Tängemo, Carolina, Linsefors, Sanna, Tuyizere, Samuel, Perkins, Rosie, Ala, Chandu, Zou, Zhiyuan, Larsson, Erik, Bergö, Martin O., Lindahl, Per

“…The mut-T homolog-1 (MTH1) inhibitor TH588 has shown promise in preclinical cancer studies but its targeting specificity has been questioned. Alternative…”
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Lack of RAC1 in macrophages protects against atherosclerosis by Bandaru, Sashidar, Ala, Chandu, Ekstrand, Matias, Akula, Murali K, Pedrelli, Matteo, Liu, Xi, Bergström, Göran, Håversen, Liliana, Borén, Jan, Bergo, Martin O, Akyürek, Levent M, Lutgens, Esther, Bader, Michael

“…The Rho GTPase RAC1 is an important regulator of cytoskeletal dynamics, but the role of macrophage-specific RAC1 has not been explored during atherogenesis. We…”
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Development and Biological Evaluation of Novel Spiro 4‐Chromanones as Potent Quorum Sensing Inhibitors by Sai Chaitanya, Kosana, Gupta, Pooja, Chitti, Surendar, Khetmalis, Yogesh Mahadu, Chandu, Ala, Murugesan, Sankaranarayanan, Pasupuleti, Mukesh

“…Infectious diseases are an integral part of human life and have the potential to cause significant damage to life. Currently, antimicrobial agents are no…”
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Discovery of potent DNMT1 inhibitors against sickle cell disease using structural-based virtual screening, MM-GBSA and molecular dynamics simulation-based approaches by Ala, Chandu, Joshi, Renuka Parshuram, Gupta, Pragya, Ramalingam, Sivaprakash, Sankaranarayanan, Murugesan

“…Sickle cell disease (SCD) is an autosomal recessive genetic disorder affecting millions of people worldwide. A reversible and selective DNMT1 inhibitor,…”
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Pharmacoinformatics-based identification of phytochemicals from Solanum torvum Swartz. fruits as potential inhibitors for MAPK14 protein by Petchimuthu, Priya, Ala, Chandu, Kunjiappan, Selvaraj, Pavadai, Parasuraman, Sankaranarayanan, Murugesan, Ram Kumar Pandian, Sureshbabu, Sundar, Krishnan

“…Plants and phytocompounds gained more attention because of their unrivalled variety of chemical diversity. In this view, the present study was executed to…”
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Microwave expedited Cu(I) catalyzed regioselective 1,2,3-triazoles as Mycobacterium Tuberculosis H37Rv inhibitors, in vitro α-amylase and α-glucosidase inhibition, in silico studies by Nesaragi, Aravind R., Kamat, Vinuta, Sharanakumar, T.M., Chandu, Ala, Barretto, Delicia A., Vidyasagar, C.C., Guddappa, Halligudra, Almutairi, Tahani Mazyad, Sankaranarayanan, Murugesan, Pandith, Anup

“…•Novel 1,2,3-triazoles (8i-t) incorporated quinoline and coumarin cores has been reported.•Huisgen 1,3-dipolar cycloaddition reaction of azide and alkyne…”
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Exploring 4-morpholinopyrrolo-[2,3-d]-pyrimidine derivatives as novel anti-cancer agents: Design, synthesis and biological studies by Nakka, Srinuvasu, Swati, Chaitanya, Kosana Sai, Sengar, Suryansh, Chandu, Ala, Sankaranarayanan, Murugesan, Sharma, Vivek, Devunuri, Nagaraju, Sekhar, Kondapalli Venkata Gowri Chandra

“…•Morpholinopyrrolo [2,3-d] pyrimidine derivatives were designed & synthesized.•Compounds were evaluated against three cancer lines MCF-7, SCC-25 and…”
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Drug Delivery Applications of Exopolysaccharides from Endophytic Bacteria Pseudomonas otitidis from Tribulus terrestris L by Kalimuthu, Arjun Kumar, Pandian, Sureshbabu Ram Kumar, Pavadai, Parasuraman, Panneerselvam, Theivendren, Kabilan, Shanmugampillai Jeyaraguru, Sankaranarayanan, Murugesan, Ala, Chandu, Kunjiappan, Selvaraj

“…The present study aimed to produce a novel biocompatible, stable and biodegradable exopolysaccharide (EPS) from endophytic bacteria to deliver drugs into…”
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Design, synthesis and biological evaluation of novel pyrido-[2,3-d]-pyrimidin-2-amine analogues as antimycobacterial agents by Kumar, Boddupalli Venkata Siva, Khetmalis, Yogesh Mahadu, Chaitanya, Kosana Sai, Chandu, Ala, Shetye, Gauri, Ma, Rui, Murugesan, Sankaranarayanan, Franzblau, Scott G., Sekhar, Kondapalli Venkata Gowri Chandra

“…•Thirty-eight Pyrido[2,3-d]pyrimidin-2-amine analogs were synthesized, characterized, and tested against Mycobacterium tuberculosis (Mtb) H37Rv.•P35 showed…”
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Design, synthesis, and biological evaluation of novel quinoxaline aryl ethers as anticancer agents by Nakka, Srinuvasu, Raza, Asif, Chaitanya, Kosana Sai, Bandaru, Naga Venkata Madhusudhan Rao, Chandu, Ala, Murugesan, Sankaranarayanan, Devunuri, Nagaraju, Sharma, Arun K., Chandrasekhar, Kondapalli Venkata Gowri

“…We designed and synthesized thirty novel quinoxaline aryl ethers as anticancer agents, and the structures of final compounds were confirmed with various…”
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Design, synthesis, and anti-mycobacterial evaluation of 1,8-naphthyridine-3-carbonitrile analogues by Khetmalis, Yogesh Mahadu, Shobha, Singarapalle, Nandikolla, Adinarayana, Chandu, Ala, Murugesan, Sankaranarayanan, Kumar, Muthyala Murali Krishna, Chandra Sekhar, Kondapalli Venkata Gowri

“…Twenty-eight compounds, , 1,8-naphthyridine-3-carbonitrile (ANC and ANA) derivatives, were designed and synthesized through a molecular hybridization approach…”
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Targeting Filamin A Reduces Macrophage Activity and Atherosclerosis by Bandaru, Sashidar, Ala, Chandu, Salimi, Reza, Akula, Murali K, Ekstrand, Matias, Devarakonda, Sravani, Karlsson, Joakim, Van den Eynden, Jimmy, Bergström, Göran, Larsson, Erik, Levin, Max, Borén, Jan, Bergo, Martin O, Akyürek, Levent M

“…BACKGROUND:The actin-binding protein FLNA (filamin A) regulates signal transduction important for cell locomotion, but the role of macrophage-specific FLNA…”
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Unlocking nitrogen compounds’ promise against malaria: A comprehensive review by Kuthe, Pranali Vijaykumar, Muzaffar‐Ur‐Rehman, Mohammad, Chandu, Ala, Prashant, Kirad Shivani, Sankarnarayanan, Murugesan

“…Plasmodium parasites are the primary cause of malaria, leading to high mortality rates, which require clinical attention. Many of the medications used in the…”
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Blocking the Cleavage of Filamin A by Calpain Inhibitor Decreases Tumor Cell Growth by Salimi, Reza, Bandaru, Sashidhar, Devarakonda, Sravani, Gökalp, Sevtap, Ala, Chandu, Alvandian, Ali, Yener, Nilgün, Akyürek, Levent M

“…Filamin A (FLNA) is the most abundant and widely expressed isoform of filamin in human tissues. It is cleaved by calpain at the hinge 1 and 2 domains,…”
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In Silico Exploration of Bisphosphonate Scaffolds as Potential Inhibitors of SARS-CoV-2 RdRp for COVID-19 and PASC by Mohammed, Muzaffar-Ur-Rehman, Chougule, Suryakant, Ala, Chandu, Kuthe, Pranali Vijaykumar, Garg, Mohit, Sankaranarayanan, Murugesan, Vasan, Seshadri S

“…The novel coronavirus disease (COVID-19) pandemic has resulted in over 720 million confirmed cases and 7 million deaths worldwide, with insufficient treatment…”
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Design, synthesis and biological evaluation of novel oxindole analogs as antitubercular agents by Khetmalis, Yogesh M, Sangeetha, Guruvelli PV, Chandu, Ala, Swati, Murugesan, Sankaranarayanan, Sharma, Vivek, Kumar, Muthyala MK, Kondapalli, Venkata GCS

“…To design, synthesize and evaluate oxindole derivatives for antitubercular activity. We synthesized the derivatives, confirmed their structures by H/ C NMR and…”
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Targeting filamin A reduces macrophage activity and atherosclerosis: Filamin A in atherogenesis by Bandaru, Sashidar, Ala, Chandu, Salimi, Reza, Akula, Murali K, Ekstrand, Matias, Devarakonda, Sravani, Karlsson, Joakim, Van den Eynden, Jimmy, Bergström, Göran, Levin, Max, Borén, Jan, Bergö, Martin O., Akyürek, Levent

“…The actin-binding protein FLNA (filamin A) regulates signal transduction important for cell locomotion, but the role of macrophage-specific FLNA during…”
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