Search Results - "Chandrasekaran, Vidya"

Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability by Chandrasekaran, Vidya, Carta, Giada, da Costa Pereira, Daniel, Gupta, Rajinder, Murphy, Cormac, Feifel, Elisabeth, Kern, Georg, Lechner, Judith, Cavallo, Anna Lina, Gupta, Shailesh, Caiment, Florian, Kleinjans, Jos C. S., Gstraunthaler, Gerhard, Jennings, Paul, Wilmes, Anja

“…The renal proximal tubule is responsible for re-absorption of the majority of the glomerular filtrate and its proper function is necessary for whole-body…”
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Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity by Miller, Galen W., Chandrasekaran, Vidya, Yaghoobi, Bianca, Lein, Pamela J.

“…•Gene-environment interactions influence risk for neurodevelopmental disorders.•Zebrafish may be useful for identifying relevant gene-environment…”
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MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons by Pravoverov, Kristina, Whiting, Katherine, Thapa, Slesha, Bushong, Trevor, Trang, Karen, Lein, Pamela J., Chandrasekaran, Vidya

“…Neuronal connectivity is dependent on size and shape of the dendritic arbor. However, mechanisms controlling dendritic arborization, especially in the…”
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An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat by Nunes, Carolina, Singh, Pranika, Mazidi, Zahra, Murphy, Cormac, Bourguignon, Aurore, Wellens, Sara, Chandrasekaran, Vidya, Ghosh, Sreya, Zana, Melinda, Pamies, David, Thomas, Aurélien, Verfaillie, Catherine, Culot, Maxime, Dinnyes, Andras, Hardy, Barry, Wilmes, Anja, Jennings, Paul, Grillari, Regina, Grillari, Johannes, Zurich, Marie-Gabrielle, Exner, Thomas

“…Most OECD guidelines for chemical risk assessment include tests performed on animals, raising financial, ethical and scientific concerns. Thus, the development…”
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The Genomics Education Partnership: Successful Integration of Research into Laboratory Classes at a Diverse Group of Undergraduate Institutions by Shaffer, Christopher D, Alvarez, Consuelo, Bailey, Cheryl, Barnard, Daron, Bhalla, Satish, Chandrasekaran, Chitra, Chandrasekaran, Vidya, Chung, Hui-Min, Dorer, Douglas R, Du, Chunguang, Eckdahl, Todd T, Poet, Jeff L, Frohlich, Donald, Goodman, Anya L, Gosser, Yuying, Hauser, Charles, Hoopes, Laura L. M, Johnson, Diana, Jones, Christopher J, Kaehler, Marian, Kokan, Nighat, Kopp, Olga R, Kuleck, Gary A, McNeil, Gerard, Moss, Robert, Myka, Jennifer L, Nagengast, Alexis, Morris, Robert, Overvoorde, Paul J, Shoop, Elizabeth, Parrish, Susan, Reed, Kelynne, Regisford, E. Gloria, Revie, Dennis, Rosenwald, Anne G, Saville, Ken, Schroeder, Stephanie, Shaw, Mary, Skuse, Gary, Smith, Christopher, Smith, Mary, Spana, Eric P, Spratt, Mary, Stamm, Joyce, Thompson, Jeff S, Wawersik, Matthew, Wilson, Barbara A, Youngblom, Jim, Leung, Wilson, Buhler, Jeremy, Mardis, Elaine R, Lopatto, David, Elgin, Sarah C. R

“…Genomics is not only essential for students to understand biology but also provides unprecedented opportunities for undergraduate research. The goal of the…”
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Tec29 controls actin remodeling and endoreplication during invagination of the Drosophila embryonic salivary glands by Chandrasekaran, Vidya, Beckendorf, Steven K

“…Epithelial invagination is necessary for formation of many tubular organs, one of which is the Drosophila embryonic salivary gland. We show that actin…”
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senseless is necessary for the survival of embryonic salivary glands in Drosophila by Chandrasekaran, Vidya, Beckendorf, Steven K

“…Apoptosis in developing Drosophila embryos is rare and confined to specific groups of cells. We explain how one organ, salivary glands, of Drosophila embryos…”
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Computing neurite outgrowth and arborization in superior cervical ganglion neurons by Henley, Rachel, Chandrasekaran, Vidya, Giulivi, Cecilia

“…•ImageJ and NeuronJ perform similarly measuring the length of dendrites per neuron.•Automated ImagePro isn’t reliable and shouldn’t be used in place of manual…”
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Culturing Rat Sympathetic Neurons from Embryonic Superior Cervical Ganglia for Morphological and Proteomic Analysis by Holt, Megan, Adams, Brandon, Chandrasekaran, Vidya

“…Sympathetic neurons from the embryonic rat superior cervical ganglia (SCG) have been used as an in vitro model system for peripheral neurons to study axonal…”
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Temporal transcriptomic alterations of cadmium exposed human iPSC-derived renal proximal tubule-like cells by Singh, Pranika, Chandrasekaran, Vidya, Hardy, Barry, Wilmes, Anja, Jennings, Paul, Exner, Thomas E.

“…Cadmium is a well-studied environmental pollutant where the kidney and particularly the proximal tubule cells are especially sensitive as they are exposed to…”
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Gamma Secretase Activity Is Necessary For BMP‐7‐Induced Dendritic Growth In Embryonic Sympathetic Neurons by Henley, Rachel, Karunungan, Krystal, Lein, Pamela, Chandrasekaran, Vidya

“…Dendrites are the primary sites of synapse formation and accurate patterning of the dendritic arbor is crucial for the normal functioning of the nervous…”
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Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound by Wellens, Sara, Dehouck, Lucie, Chandrasekaran, Vidya, Singh, Pranika, Loiola, Rodrigo Azevedo, Sevin, Emmanuel, Exner, Thomas, Jennings, Paul, Gosselet, Fabien, Culot, Maxime

“…The blood-brain barrier (BBB) is a highly restrictive barrier that preserves central nervous system homeostasis and ensures optimal brain functioning. Using…”
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Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons by Karunungan, Krystal, Garza, Rachel H., Grodzki, Ana Cristina, Holt, Megan, Lein, Pamela J., Chandrasekaran, Vidya

“…Autonomic dysfunction has been observed in Alzheimer's disease (AD); however, the effects of genes involved in AD on the peripheral nervous system are not well…”
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Embryonic and cellular effects after exposure to commonly consumed energy drinks by Doyle, Wayne, Chandrasekaran, Vidya

“…The aim of this study was to examine the effects of popular “energy drinks,” on both an embryological and cellular level. 1‐day old chick embryos treated with…”
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Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons by Chandrasekaran, Vidya, Lea, Charlotte, Sosa, Jose Carlo, Higgins, Dennis, Lein, Pamela J.

“…Previous studies have shown that bone morphogenetic proteins (BMPs) promote dendritic growth in sympathetic neurons; however, the downstream signaling…”
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A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro by Ramm, Susanne, Todorov, Petar, Chandrasekaran, Vidya, Dohlman, Anders, Monteiro, Maria B, Pavkovic, Mira, Muhlich, Jeremy, Shankaran, Harish, Chen, William W, Mettetal, Jerome T, Vaidya, Vishal S

“…Abstract The failure to predict kidney toxicity of new chemical entities early in the development process before they reach humans remains a critical issue…”
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Evaluation of the impact of iPSC differentiation protocols on transcriptomic signatures by Chandrasekaran, Vidya, Wellens, Sara, Bourguignon, Aurore, Djidrovski, Ivo, Fransen, Leonie, Ghosh, Sreya, Mazidi, Zahra, Murphy, Cormac, Nunes, Carolina, Singh, Pranika, Zana, Melinda, Armstrong, Lyle, Dinnyés, András, Grillari, Johannes, Grillari-Voglauer, Regina, Leonard, Martin O., Verfaillie, Catherine, Wilmes, Anja, Zurich, Marie-Gabrielle, Exner, Thomas, Jennings, Paul, Culot, Maxime

“…Human induced pluripotent stem cells (iPSC) have the potential to produce desired target cell types in vitro and allow for the high-throughput screening of…”
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A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation by Monteiro, Maria B, Ramm, Susanne, Chandrasekaran, Vidya, Boswell, Sarah A, Weber, Elijah J, Lidberg, Kevin A, Kelly, Edward J, Vaidya, Vishal S

“…The death of epithelial cells in the proximal tubules is thought to be the primary cause of AKI, but epithelial cells that survive kidney injury have a…”
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The effects of energy beverages on cultured cells by Doyle, Wayne, Shide, Eric, Thapa, Slesha, Chandrasekaran, Vidya

“…► Rat embryonic fibroblasts showed dose dependent delays in wound healing when treated with energy beverages. ► Similar delays in wound healing were observed…”
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Free radicals are important for dendritic growth in rat embryonic sympathetic neurons by Chandrasekaran, Vidya, Lea, Charlotte, Lein, Pamela

“…Abstract only Dendritic growth and retraction are important hallmarks of neuronal growth and injury respectively. It is therefore important to elucidate the…”
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