Search Results - "Chandramohan, Vidya"

Altered ontogeny and transcriptomic signatures of tissue-resident pulmonary interstitial macrophages ameliorate allergic airway hyperresponsiveness by Tighe, Robert M, Birukova, Anastasiya, Malakhau, Yuryi, Kobayashi, Yoshihiko, Vose, Aaron T, Chandramohan, Vidya, Cyphert-Daly, Jaime M, Cumming, R Ian, Fradin Kirshner, Helene, Tata, Purushothama R, Ingram, Jennifer L, Gunn, Michael D, Que, Loretta G, Yu, Yen-Rei A

“…Environmental exposures and experimental manipulations can alter the ontogenetic composition of tissue-resident macrophages. However, the impact of these…”
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Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs by Brown, Michael C, Holl, Eda K, Boczkowski, David, Dobrikova, Elena, Mosaheb, Mubeen, Chandramohan, Vidya, Bigner, Darell D, Gromeier, Matthias, Nair, Smita K

“…Tumors thrive in an immunosuppressive microenvironment that impedes antitumor innate and adaptive immune responses. Thus, approaches that can overcome…”
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EXTH-39. D2C7-CAR: A NOVEL, DUAL-SPECIFIC CHIMERIC ANTIGEN RECEPTOR T CELL WITH HIGH SPECIFICITY FOR EGFR AND EGFRVIII IMPROVES SURVIVAL IN EGFR/EGFRVIII GLIOBLASTOMA AND EGFR OVER-EXPRESSING MEDULLOBLASTOMA by Wilson, Zach, Wilkinson, Daniel, Ryan, Katherine, Chandramohan, Vidya, Bigner, Darrell, Fecci, Peter

“…Abstract BACKGROUND GBM is the most common primary malignant brain tumor found in adults. Despite strenuous efforts at improving outcomes, overall survival…”
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EPCO-50. THE TRANSCRIPTIONAL LANDSCAPE OF KEY INNATE DNA SENSORS WITHIN PRIMARY BRAIN TUMORS by Mangoli, Avani, Bowie, Michelle, Ashley, David, Low, Justin, Stevenson, Kevin, Chandramohan, Vidya, Hariharan, Seetha

“…Abstract Primary brain tumors are notoriously resistant to immunotherapy. The efficacy of these treatments potentially requires normal expression of DNA innate…”
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Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma by Thompson, Eric M, Brown, Michael, Dobrikova, Elena, Ramaswamy, Vijay, Taylor, Michael D, McLendon, Roger, Sanks, Jennifer, Chandramohan, Vidya, Bigner, Darell, Gromeier, Matthias

“…Abstract Poliovirus oncolytic immunotherapy is a putatively novel approach to treat pediatric brain tumors. This work sought to determine expression of the…”
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CTIM-09. PHASE 1/1B TRIAL OF FC-ENGINEERED ANTI-CD40 AGONIST MONOCLONAL ANTIBODY (2141-V11) INFUSED WITH D2C7-IT IN ENHANCING DISEASE BY CONVECTION-ENHANCED DELIVERY (CED) FOR RECURRENT MALIGNANT GLIOMA (RMG) by Desjardins, Annick, Chandramohan, Vidya, Landi, Daniel, Peters, Katherine, Johnson, Margaret O, Low, Justin, Khasraw, Mustafa, Threatt, Stevie, Bullock, Chevelle, Herndon, James, Lipp, Eric, Friedman, Allan, Friedman, Henry, Ashley, David, Osorio, Juan, Ravetch, Jeffrey, Bigner, Darell

“…Abstract BACKGROUND D2C7-IT is a dual-specific immunotoxin. Recombinant antibody fragments bind the wild-type epidermal growth factor receptor (EGFRwt) and its…”
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IMMU-11. NLRP3+ TUMOR-ASSOCIATED MYELOID CELLS ARE ENRICHED IN ASTROCYTIC GLIOMAS AND REPRESENT A THERAPEUTIC VULNERABILITY by Chandramohan, Vidya, Stevenson, Kevin, Yu, Yen-Rei Andrea, Reitman, Zachary, He, Yiping, McLendon, Roger, Osorio, Cristina, Gregory, Simon, Lipp, Eric, Desjardins, Annick, Friedman, Allan, Nair, Smita, Patel, Anoop, Bigner, Darell, Ashley, David

“…Abstract BACKGROUND Tumor-associated myeloid cells (TAMs) are known drivers of immunosuppression and glioma progression. Hence novel approaches for…”
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STING is silenced by DNA methylation in primary brain tumors and is rescued by methyltransferase inhibition (P13-9.004) by Low, Justin, Chandramohan, Vidya, Bowie, Michelle, Brown, Michael, Waitkus, Matthew, Briley, Aaron, Stevenson, Kevin, Fuller, Rebecca, Reitman, Zachary, Muscat, Andrea, Hariharan, Seethalakshmi, Hostettler, Janell, Wong, Nicholas, Gromeier, Matthias, Ashley, David

“…Abstract only…”
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CTIM-13. D2C7-IT IN COMBINATION WITH AN FC-ENGINEERED ANTI-HUMANCD40 MONOCLONAL ANTIBODY (2141-V11) ADMINISTERED INTRATUMORALLY VIA CONVECTION-ENHANCED DELIVERY (CED) FOLLOWED BY CERVICAL PERILYMPHATIC INJECTIONS (CPLIS) OF 2141-V11 IN PATIENTS WITH RECURRENT GLIOBLASTOMA (RGBM) by Desjardins, Annick, Chandramohan, Vidya, Herndon, James E II, Threatt, Stevie, Bullock, Chevelle, Bradbury, Claire, Johnson, Margaret O, Khasraw, Mustafa, Low, Justin T, Peters, Katherine B, Shoaf, Madison, Landi, Daniel, Batich, Kristen, Friedman, Allan H, Friedman, Henry S, Ashley, David M, Knorr, David, Osorio, Juan, Ravetch, Jeffrey, Bigner, Darell D

“…Abstract BACKGROUND The combination of D2C7-IT, an antibody toxin conjugate, and anti-mouseCD40 via CED generates robust antitumor immunity by killing tumor…”
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EPCO-21. STING PROMOTER EPIGENETIC SILENCING IN GLIOBLASTOMA by Low, Justin, Bowie, Michelle, Chandramohan, Vidya, Fuller, Rebecca, Muscat, Andrea, Brown, Michael, Hariharan, Seethalakshmi, Hostettler, Janell, Briley, Aaron, Danehower, Sarah, Baker, Ali, Wong, Nick, Ashley, David

“…Abstract The Stimulator of interferon genes (STING) protein is a critical component of the innate immune response to pathogenic and cytosolic self DNA. The…”
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IMMU-21. TARGETING EGFR IN HYPOMUTATED PEDIATRIC BRAIN TUMORS USING THE D2C7 IMMUNOTOXIN by Landi, Daniel, Thompson, Eric, McLendon, Roger, Desjardins, Annick, Chandramohan, Vidya, Ashley, David, Bigner, Darell

“…Abstract BACKGROUND EGFR is a receptor tyrosine kinase that is hyperactivated or overexpressed in many human cancers. Compared with brain tumors in adults,…”
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CTIM-23. DOSE ESCALATION TRIAL OF FC-ENGINEERED ANTI-CD40 MONOCLONAL ANTIBODY (2141-V11) ADMINISTERED INTRATUMORALLY WITH D2C7-IT VIA CONVECTION-ENHANCED DELIVERY (CED) FOR RECURRENT MALIGNANT GLIOMAS (RMGS) by Desjardins, Annick, Chandramohan, Vidya, Landi, Daniel, Peters, Katherine B, Johnson, Margaret, Khasraw, Mustafa, Low, Justin, Threatt, Stevie, Bullock, Chevelle, II, James E Herndon, Lipp, Eric S, Sampson, John, Friedman, Allan, Friedman, Henry S, Ashley, David, Knorr, David, Ravetch, Jeffrey, Bigner, Darell

“…Abstract BACKGROUND D2C7-IT, a novel immunotoxin-based cytotoxic therapy, targets epidermal growth factor receptor (EGFR) and mutant EGFR variant III. In…”
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PDTM-46. POLIOVIRUS RECEPTOR (CD155) EXPRESSION IN PEDIATRIC BRAIN TUMORS MEDIATES ONCOLYSIS OF MEDULLOBLASTOMA AND PLEOMORPHIC XANTHOASTROCYTOMA by Thompson, Eric, Brown, Michael, Dobrikova, Elena, Ramaswamy, Vijay, Taylor, Michael, McLendon, Roger, Chandramohan, Vidya, Bigner, Darell, Gromeier, Matthias

“…Abstract INTRODUCTION Poliovirus oncolytic viral immunotherapy is a putatively novel approach to treat both low grade and malignant pediatric brain tumors…”
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CTIM-23. A PHASE 1 TRIAL OF D2C7-IT IN COMBINATION WITH ATEZOLIZUMAB IN RECURRENT WHO GRADE IV MALIGNANT GLIOMA (MG) by Desjardins, Annick, Randazzo, Dina, Chandramohan, Vidya, Peters, Katherine, Johnson, Margaret, Landi, Daniel, Khasraw, Mustafa, Threatt, Stevie, Bullock, Chevelle, Herndon, James, Lipp, Eric, Sampson, John, Friedman, Allan, Friedman, Henry, Ashley, David, Bigner, Darell

“…Abstract BACKGROUND D2C7 immunotoxin (D2C7-IT) is a dual-specific recombinant immunotoxin comprising an EGFR-wt and mutant-specific (EGFRvIII) monoclonal…”
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ATIM-24. DOSE FINDING AND DOSE EXPANSION TRIAL OF D2C7 IMMUNOTOXIN (D2C7-IT) ADMINISTERED INTRATUMORALLY VIA CONVECTION-ENHANCED DELIVERY (CED) FOR RECURRENT MALIGNANT GLIOMA (MG) by Desjardins, Annick, Randazzo, Dina, Chandramohan, Vidya, Peters, Katherine, Johnson, Margaret, Threatt, Stevie, Bullock, Chevelle, Jackman, Jenny, Healy, Patrick, Lipp, Eric, Sampson, John, Friedman, Allan, Friedman, Henry, Ashley, David, Bigner, Darell

“…Abstract BACKGROUND D2C7-IT is a recombinant immunotoxin comprised of a dual-specific antibody fragment targeting EGFRwt and EGFRvIII and a genetically…”
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BSCI-20 STING EPIGENETIC SILENCING IN GLIOMAS CAN BE RESCUED BY METHYLTRANSFERASE INHIBITION: IMPLICATIONS FOR NOVEL THERAPEUTIC APPROACHES by Low, Justin, Chandramohan, Vidya, Bowie, Michelle, Brown, Michael, Waitkus, Matthew, Briley, Aaron, Stevenson, Kevin, Fuller, Rebecca, Hostettler, Janell, Reitman, Zachary, Charbonneau, Casey, Keir, Stephen, Khasraw, Mustafa, Ashley, David

“…Abstract The stimulator of interferon genes (STING) is a key component of the innate immune response to pathogenic cytosolic DNA, resulting in IRF3- and…”
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ATIM-36. DOSE ESCALATION TRIAL OF D2C7 IMMUNOTOXIN (D2C7-IT) ADMINISTERED INTRATUMORALLY VIA CONVECTION-ENHANCED DELIVERY (CED) FOR RECURRENT MALIGNANT GLIOMA (MG) by Desjardins, Annick, Randazzo, Dina, Chandramohan, Vidya, Peters, Katherine, Johnson, Margaret, Thomas, Leslie, Threatt, Stevie, Bullock, Chevelle, Herndon, James, Boulton, Susan, Healy, Patrick, Lipp, Eric, Sampson, John, Friedman, Allan, Friedman, Henry, Ashley, David, Bigner, Darell

“…Abstract BACKGROUND D2C7-IT is a recombinant immunotoxin comprised of a dual-specific antibody fragment targeting EGFRwt and EGFRvIII and a genetically…”
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ATIM-18. PHASE I DOSE ESCALATION STUDY OF D2C7-IT ADMINISTERED INTRATUMORALLY VIA CONVECTION-ENHANCED DELIVERY (CED) FOR RECURRENT MALIGNANT GLIOMA (MG) by Desjardins, Annick, Randazzo, Dina, Chandramohan, Vidya, Sampson, John, Peters, Katherine, Vlahovic, Gordana, Threatt, Stevie, Herndon, James, Boulton, Susan, Lally-Goss, Denise, Healy, Patrick, Lipp, Eric, Friedman, Allan, Friedman, Henry, Bigner, Darell

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PDTM-46. POLIOVIRUS RECEPTOR (CD155) EXPRESSION IN PEDIATRIC BRAIN TUMORS MEDIATES ONCOLYSIS OF MEDULLOBLASTOMA AND PLEOMORPHIC XANTHOASTROCYTOMA by Thompson, Eric, Brown, Michael, Dobrikova, Elena, Ramaswamy, Vijay, Taylor, Michael, McLendon, Roger, Chandramohan, Vidya, Bigner, Darell, Gromeier, Matthias

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IDH1 MUTATIONS AS A IMMUNOTHERAPEUTIC TARGET FOR BRAIN TUMORS by Archer, G. E., Reap, E., Norberg, P., Cui, X., Schmittling, R., Herndon, J., Chandramohan, V., Riccione, K., Kuan, C.-T., Yan, H., Bigner, D. D., Sampson, J. H.

“…BACKGROUND: Immunotherapy promises an exquisitely precise therapeutic approach, and substantial evidence suggests that activated T cells can eradicate large…”
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