Search Results - "Chandra Mangalhara, Kailash"

DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages by Cobo, Isidoro, Tanaka, Tiffany N., Chandra Mangalhara, Kailash, Lana, Addison, Yeang, Calvin, Han, Claudia, Schlachetzki, Johannes, Challcombe, Jean, Fixsen, Bethany R., Sakai, Mashito, Li, Rick Z., Fields, Hannah, Mokry, Michal, Tsai, Randy G., Bejar, Rafael, Prange, Koen, de Winther, Menno, Shadel, Gerald S., Glass, Christopher K.

“…Deleterious somatic mutations in DNA methyltransferase 3 alpha (DNMT3A) and TET mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of…”
Get full text

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence by Harel, Michal, Ortenberg, Rona, Varanasi, Siva Karthik, Mangalhara, Kailash Chandra, Mardamshina, Mariya, Markovits, Ettai, Baruch, Erez N., Tripple, Victoria, Arama-Chayoth, May, Greenberg, Eyal, Shenoy, Anjana, Ayasun, Ruveyda, Knafo, Naama, Xu, Shihao, Anafi, Liat, Yanovich-Arad, Gali, Barnabas, Georgina D., Ashkenazi, Shira, Besser, Michal J., Schachter, Jacob, Bosenberg, Marcus, Shadel, Gerald S., Barshack, Iris, Kaech, Susan M., Markel, Gal, Geiger, Tamar

“…Immunotherapy has revolutionized cancer treatment, yet most patients do not respond. Here, we investigated mechanisms of response by profiling the proteome of…”
Get full text

DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology by Saini, Sunil Kumar, Mangalhara, Kailash Chandra, Prakasam, Gopinath, Bamezai, R. N. K.

“…Here we demonstrate localization of the isoform3 of DNA Methyltransferase1 (DNMT1) enzyme to mitochondria, instead of isoform1 as reported earlier. The fused…”
Get full text

ERK2-ZEB1-miR-101-1 axis contributes to epithelial–mesenchymal transition and cell migration in cancer by Chandra Mangalhara, Kailash, Manvati, Siddharth, Saini, Sunil Kumar, Ponnusamy, Kalaiarasan, Agarwal, Gaurav, Abraham, Suresh K, Bamezai, Rameshwar N.K

“…Abstract Regulation of metastasis continues to remain enigmatic despite our improved understanding of cancer. Identification of microRNAs associated with…”
Get full text

miR-145 supports cancer cell survival and shows association with DDR genes, methylation pattern, and epithelial to mesenchymal transition by Manvati, Siddharth, Mangalhara, Kailash Chandra, Kalaiarasan, Ponnuswamy, Chopra, Rupali, Agarwal, Gaurav, Kumar, Rakesh, Saini, Sunil Kumar, Kaushik, Monika, Arora, Ankita, Kumari, Usha, Bamezai, Rameshwar Nath Koul, Dhar, Pawan Kumar

“…Despite several reports describing the dual role of miR-145 as an oncogene and a tumor suppressor in cancer, not much has been resolved and understood. In this…”
Get full text

MiR-101 induces senescence and prevents apoptosis in the background of DNA damage in MCF7 cells by Manvati, Siddharth, Mangalhara, Kailash Chandra, Kalaiarasan, P, Srivastava, Niloo, Kumar, Bhupender, Bamezai, R N K

“…Moderately increased DNA damage due to the exogenous miR-101 (4 fold) over-expression in MCF7 cells was substantiated by an increase in the number of γ-H2AX…”
Get full text

Manipulating mitochondrial electron flow enhances tumor immunogenicity by Mangalhara, Kailash Chandra, Varanasi, Siva Karthik, Johnson, Melissa A, Burns, Mannix J, Rojas, Gladys R, Esparza Moltó, Pau B, Sainz, Alva G, Tadepalle, Nimesha, Abbott, Keene L, Mendiratta, Gaurav, Chen, Dan, Farsakoglu, Yagmur, Kunchok, Tenzin, Hoffmann, Filipe Araujo, Parisi, Bianca, Rincon, Mercedes, Vander Heiden, Matthew G, Bosenberg, Marcus, Hargreaves, Diana C, Kaech, Susan M, Shadel, Gerald S

“…Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative contribution of complex I (CI) and complex II (CII), the…”
Get full text

miR-24-2 regulates genes in survival pathway and demonstrates potential in reducing cellular viability in combination with docetaxel by Manvati, Siddharth, Mangalhara, Kailash Chandra, Kalaiarasan, P., Srivastava, Niloo, Bamezai, R.N.K.

“…MicroRNAs the small (18–22 in length) noncoding RNA molecules are negative regulators of gene expression, modulating biological processes of cell…”
Get full text

Deciphering the role of microRNA – A step by step guide by Manvati, Siddharth, Mangalhara, Kailash Chandra, Khan, Juveria, Pathania, Geeta Lal, Kaul, Srishti, Kaushik, Monika, Arora, Ankita, Dhar, Pawan K.

“…MicroRNAs (miRNAs), are small non-coding RNAs of approximately 22 nucleotides in length, playing an important role in regulating gene expression…”
Get full text

MiR-101 Induces Senescence and Prevents Apoptosis in the Background of DNA Damage in MCF7 Cells: e111177 by Manvati, Siddharth, Mangalhara, Kailash Chandra, Kalaiarasan, P, Srivastava, Niloo, Kumar, Bhupender, Bamezai, R NK

“…Moderately increased DNA damage due to the exogenous miR-101 (4 fold) over-expression in MCF7 cells was substantiated by an increase in the number of gamma…”
Get full text