Search Results - "Chandra, J N Narendra Sharath"

Synthesis and pharmacological evaluation of novel N-alkyl/aryl substituted thiazolidinone arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia models by Sadashiva, C.T., Narendra Sharath Chandra, J.N., Kavitha, C.V., Thimmegowda, A., Subhash, M.N., Rangappa, Kanchugarakoppal S.

“…Earlier we have reported the effect of arecoline thiazolidinone and morpholino arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia…”
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Acetylcholine and memory-enhancing activity of Ficus racemosa bark by Ahmed, Faiyaz, Chandra, J N Narendra Sharath, Manjunath, S

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and enhancement of acetylcholine (Ach) levels in brain using…”
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Active site directed docking studies: Synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase by Girisha, H.R., Narendra Sharath Chandra, J.N., Boppana, Sriramamurthy, Malviya, Manish, Sadashiva, C.T., Rangappa, Kanchugarakoppal S.

“…Hypocholinergic function associated with Alzheimer's disease (AD) is well-accepted hypothesis, in this regard, many research attempts have been made to elevate…”
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Design, synthesis, in silico and in vitro evaluation of thiophene derivatives: A potent tyrosine phosphatase 1B inhibitor and anticancer activity by Gulipalli, Kali Charan, Bodige, Srinu, Ravula, Parameshwar, Endoori, Srinivas, Vanaja, G.R., Suresh Babu, G., Narendra Sharath Chandra, J.N., Seelam, Nareshvarma

“…[Display omitted] •A novel series of 3-methoxythiophene-2-carboxylate derivatives have been synthesized.•The series of compounds were evaluated for their…”
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Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-[bis(4-fluorophenyl)-methyl]piperazine by Narendra Sharath Chandra, J.N., Sadashiva, C.T., Kavitha, C.V., Rangappa, K.S.

“…A series of novel substituted 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives (2a–m) have been synthesized. The synthesized compounds were characterized…”
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Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer’s disease by Sadashiva, C.T., Narendra Sharath Chandra, J.N., Ponnappa, K.C., Veerabasappa Gowda, T., Rangappa, Kanchugarakoppal S.

“…The novel bioactive 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives were synthesized under mild conditions using different aryl/alkyl halides and…”
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Design, Synthesis, and Docking Studies of Novel Dimethyl Triazene Incorporated Thiazolyl Pyrazolines for Anticancer Activity by Ravula, Parameshwar, Vamaraju, Harinadha Babu, Paturi, Manichandrika, Bodige, Srinu, Gulipalli, Kali Charan, Narendra Sharath Chandra, J. N.

“…A novel series of dimethyl triazene incorporated thiazolyl pyrazolines have been designed on the basis of hybridization and also in support with…”
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Design, synthesis, antitubercular and antibacterial activities of pyrrolo[3,2-b]pyridine-3-carboxamide linked 2-methoxypyridine derivatives and in silico docking studies by Bodige, Srinu, Ravula, Parameshwar, Gulipalli, Kali Charan, Endoori, Srinivas, Cherukumalli, Purna Koteswara Rao, JN, Narendra Sharath Chandra, Seelam, Nareshvarma

“…A novel series pyrrolo[3,2-b]pyridine-3-carboxamide linked 2-methoxypyridine derivatives have been designed, synthesized and confirmed by FT-IR, 1 H NMR, 13 C…”
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Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: Derivatives of irbesartan key intermediate by Kavitha, C.V., Gaonkar, S.L., Narendra Sharath Chandra, J.N., Sadashiva, C.T., Rangappa, K.S.

“…A series of novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-one derivatives have been synthesized by interaction of 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-one…”
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Synthesis, Antitubercular Activity, and Molecular Docking Studies of Novel 2-(4-Chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamides by Srinu, B., Parameshwar, R., Kali Charan, G., Srinivas, E., Koteswara Rao, Ch. P., Narendra Sharath Chandra, J. N., Naresh Varma, S.

“…A novel series of 2-(4-chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamide derivatives are synthesized and their structures are confirmed by…”
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Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives by Sathisha, K.R., Khanum, Shaukath A., Chandra, J.N. Narendra Sharath, Ayisha, F., Balaji, S., Marathe, Gopal K., Gopal, Shubha, Rangappa, K.S.

“…Synthesized title compounds 6a–t are characterized by spectroscopic techniques and elemental analysis. Four (6a, 6b, 6d and 6f) out of 20 synthesized molecules…”
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Synthesis and Anticancer Activity of Thiophene-2-carboxamide Derivatives and In Silico Docking Studies by Gulipalli, K. C., Ravula, P., Bodige, S., Endoori, S., Cherukumalli, P. K. R., Narendra Sharath Chandra, J. N., Seelam, N.

“…A novel series of thiophene-2-carboxamide derivatives are designed and synthesized, and their structures are confirmed by 1 H and 13 C NMR, and mass spectra…”
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Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models by Chandra, J.N. Narendra Sharath, Malviya, Manish, Sadashiva, C.T., Subhash, M.N., Rangappa, Kanchugarakoppal S.

“…The discovery of cholinergic deficit in Alzheimer's disease (AD) patient's brain has triggered research efforts, using cholinomimetic approaches for their…”
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Thienopyrimidines as Novel Inhibitors of Mycobacterium tuberclosis: Synthesis and In-vitro Studies by Rashmi, P., Nargund, Laxmi Venkatesh Gurachar, Hazra, Kuntal, Chandra, J. N. Narendra Sharath

“…A series of novel 5,6‐unsubstituted thieno‐[2,3‐d]‐pyrimidines has been synthesized and tested for growth inhibition of Mycobacterium tuberculosis H37Rv. Of…”
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Synthesis and Comparative Study of Anti-Mycobacterium Activity of a Novel Series of Fluoronitrobenzothiazolopyrazoline Regioisomers by Hazra, K., Nargund, L. V. G., Rashmi, P., Narendra Sharath Chandra, J. N., Nandha, B., Harish, M. S.

“…In an attempt to find a new and a safer drug for tuberculosis, we have synthesized a series of fluoronitrobenzothiazolopyrazolines for antitubercular activity…”
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Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma by Prashanth, T., Avin, B.R. Vijay, Thirusangu, Prabhu, Ranganatha, V. Lakshmi, Prabhakar, B.T., Sharath Chandra, J.N. Narendra, Khanum, Shaukath Ara

“…[Display omitted] •Novel coumarin analogs were synthesized with verity of substituents.•Docking studies have been done for the potent compound 13f.•In vitro…”
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Muscarinic receptor 1 agonist activity of novel N-arylthioureas substituted 3-morpholino arecoline derivatives in Alzheimer’s presenile dementia models by Malviya, Manish, Kumar, Y.C. Sunil, Asha, D., Chandra, J.N. Narendra Sharath, Subhash, M.N., Rangappa, K.S.

“…As part of our continuing effort aimed at the development of selective, efficacious and centrally active M1 muscarinic agonists for the treatment of…”
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Effect of novel N-aryl sulfonamide substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimer’s dementia models by Kumar, Y.C. Sunil, Malviya, Manish, Chandra, J.N. Narendra Sharath, Sadashiva, C.T., Kumar, C.S. Ananda, Prasad, S.B. Benaka, Prasanna, D.S., Subhash, M.N., Rangappa, K.S.

“…A series of novel, potent, and selective muscarinic receptor 1 agonists (M1 receptor agonists) that employ a key N-substituted morpholine Arecoline moiety has…”
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Design, Synthesis, Anti-Cancer Activity, and in silico Studies of Novel Imidazo[1,2-a]pyridine Derivatives by Endoori, S., Gulipalli, K. C., Bodige, S., Chandra, J. N. Narendra Sharath, Seelam, N.

“…A novel series of imidazo [1,2- a ]pyridine derivatives has been designed, synthesized and tested for the anti-proliferative activity against three different…”
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Design, Synthesis, Antitubercular and Antibacterial Activities of 1,3,5-Triazinyl Carboxamide Derivatives and In Silico Docking Studies by Bodige, S., Ravula, P., Gulipalli, K. Ch, Endoori, S., Cherukumalli, P. Koteswara Rao, Chandra, J. N. Narendra Sharath, Seelam, N.

“…A series of novel N -{2-fluoro-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)methyl]phenyl} carboxamide derivatives has been synthesized, and their molecular structures…”
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