Search Results - "Chandler, Shane A."

Quantitative mass imaging of single biological macromolecules by Young, Gavin, Hundt, Nikolas, Cole, Daniel, Fineberg, Adam, Andrecka, Joanna, Tyler, Andrew, Olerinyova, Anna, Ansari, Ayla, Marklund, Erik G, Collier, Miranda P, Chandler, Shane A, Tkachenko, Olga, Allen, Joel, Crispin, Max, Billington, Neil, Takagi, Yasuharu, Sellers, James R, Eichmann, Cédric, Selenko, Philipp, Frey, Lukas, Riek, Roland, Galpin, Martin R, Struwe, Weston B, Benesch, Justin L P, Kukura, Philipp

“…The cellular processes underpinning life are orchestrated by proteins and their interactions. The associated structural and dynamic heterogeneity, despite…”
Get full text

Discovery of a Highly Selective Cell‐Active Inhibitor of the Histone Lysine Demethylases KDM2/7 by Gerken, Philip A., Wolstenhulme, Jamie R., Tumber, Anthony, Hatch, Stephanie B., Zhang, Yijia, Müller, Susanne, Chandler, Shane A., Mair, Barbara, Li, Fengling, Nijman, Sebastian M. B., Konietzny, Rebecca, Szommer, Tamas, Yapp, Clarence, Fedorov, Oleg, Benesch, Justin L. P., Vedadi, Masoud, Kessler, Benedikt M., Kawamura, Akane, Brennan, Paul E., Smith, Martin D.

“…Histone lysine demethylases (KDMs) are of critical importance in the epigenetic regulation of gene expression, yet there are few selective, cell‐permeable…”
Get full text

Mass spectrometry beyond the native state by Chandler, Shane A, Benesch, Justin LP

“…•Native mass spectrometry allows the interrogation of protein conformational space.•Manipulation of charge populates different minima in the protein folding…”
Get full text

Origin of complexity in haemoglobin evolution by Pillai, Arvind S., Chandler, Shane A., Liu, Yang, Signore, Anthony V., Cortez-Romero, Carlos R., Benesch, Justin L. P., Laganowsky, Arthur, Storz, Jay F., Hochberg, Georg K. A., Thornton, Joseph W.

“…Most proteins associate into multimeric complexes with specific architectures 1 , 2 , which often have functional properties such as cooperative ligand binding…”
Get full text

Probing the Dissociation of Protein Complexes by Means of Gas-Phase H/D Exchange Mass Spectrometry by Mistarz, Ulrik H., Chandler, Shane A., Brown, Jeffery M., Benesch, Justin L. P., Rand, Kasper D.

“…Gas-phase hydrogen/deuterium exchange measured by mass spectrometry (gas-phase HDX-MS) is a fast method to probe the conformation of protein ions. The use of…”
Get full text

Author Correction: Origin of complexity in haemoglobin evolution by Pillai, Arvind S., Chandler, Shane A., Liu, Yang, Signore, Anthony V., Cortez-Romero, Carlos R., Benesch, Justin L. P., Laganowsky, Arthur, Storz, Jay F., Hochberg, Georg K. A., Thornton, Joseph W.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Engineering of a Polydisperse Small Heat-Shock Protein Reveals Conserved Motifs of Oligomer Plasticity by Mishra, Sanjay, Chandler, Shane A., Williams, Dewight, Claxton, Derek P., Koteiche, Hanane A., Stewart, Phoebe L., Benesch, Justin L.P., Mchaourab, Hassane S.

“…Small heat-shock proteins (sHSPs) are molecular chaperones that bind partially and globally unfolded states of their client proteins. Previously, we discovered…”
Get full text

Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System by Pliotas, Christos, Grayer, Samuel C, Ekkerman, Silvia, Chan, Anthony K. N, Healy, Jess, Marius, Phedra, Bartlett, Wendy, Khan, Amjad, Cortopassi, Wilian A, Chandler, Shane A, Rasmussen, Tim, Benesch, Justin L. P, Paton, Robert S, Claridge, Timothy D. W, Miller, Samantha, Booth, Ian R, Naismith, James H, Conway, Stuart J

“…Ligand binding is one of the most fundamental properties of proteins. Ligand functions fall into three basic types: substrates, regulatory molecules, and…”
Get full text

Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry by Abramsson, Mia L, Sahin, Cagla, Hopper, Jonathan T. S, Branca, Rui M. M, Danielsson, Jens, Xu, Mingming, Chandler, Shane A, Österlund, Nicklas, Ilag, Leopold L, Leppert, Axel, Costeira-Paulo, Joana, Lang, Lisa, Teilum, Kaare, Laganowsky, Arthur, Benesch, Justin L. P, Oliveberg, Mikael, Robinson, Carol V, Marklund, Erik G, Allison, Timothy M, Winther, Jakob R, Landreh, Michael

“…In solution, the charge of a protein is intricately linked to its stability, but electrospray ionization distorts this connection, potentially limiting the…”
Get full text

Monitoring protein-metal binding by F NMR - a case study with the New Delhi metallo-β-lactamase 1 by Rydzik, Anna M, Brem, Jürgen, Chandler, Shane A, Benesch, Justin L. P, Claridge, Timothy D. W, Schofield, Christopher J

“…19 F NMR protein observed spectroscopy is evaluated as a method for analysing protein metal binding using the New Delhi metallo-β-lactamase 1. The results…”
Get full text

Monitoring protein-metal binding by 19 F NMR - a case study with the New Delhi metallo-β-lactamase 1 by Rydzik, Anna M, Brem, Jürgen, Chandler, Shane A, Benesch, Justin L P, Claridge, Timothy D W, Schofield, Christopher J

“…F NMR protein observed spectroscopy is evaluated as a method for analysing protein metal binding using the New Delhi metallo-β-lactamase 1. The results imply F…”
Get full text

Discovery of a Highly Selective Cell‐Active Inhibitor of the Histone Lysine Demethylases KDM2/7 by Gerken, Philip A., Wolstenhulme, Jamie R., Tumber, Anthony, Hatch, Stephanie B., Zhang, Yijia, Müller, Susanne, Chandler, Shane A., Mair, Barbara, Li, Fengling, Nijman, Sebastian M. B., Konietzny, Rebecca, Szommer, Tamas, Yapp, Clarence, Fedorov, Oleg, Benesch, Justin L. P., Vedadi, Masoud, Kessler, Benedikt M., Kawamura, Akane, Brennan, Paul E., Smith, Martin D.

“…Histone lysine demethylases (KDMs) are of critical importance in the epigenetic regulation of gene expression, yet there are few selective, cell‐permeable…”
Get full text

Quantitative mass imaging of single molecules by Young, Gavin, Hundt, Nikolas, Cole, Daniel, Fineberg, Adam, Andrecka, Joanna, Tyler, Andrew, Olerinyova, Anna, Ansari, Ayla, Marklund, Erik G., Collier, Miranda P., Chandler, Shane A., Tkachenko, Olga, Allen, Joel, Crispin, Max, Billington, Neil, Takagi, Yasuharu, Sellers, James R., Eichmann, Cédric, Selenko, Philipp, Frey, Lukas, Riek, Roland, Galpin, Martin R., Struwe, Weston B., Benesch, Justin L.P., Kukura, Philipp

“…The cellular processes underpinning life are orchestrated by proteins and their interactions. Investigating the structural and dynamic heterogeneity of…”
Get full text

Monitoring protein-metal binding by 19F NMR – a case study with the New Delhi metallo-β-lactamase 1† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9md00416e by Rydzik, Anna M., Brem, Jürgen, Chandler, Shane A., Benesch, Justin L. P., Claridge, Timothy D. W., Schofield, Christopher J.

“…19 F protein labeling enables monitoring of metal binding to the active site of NDM-1. 19 F NMR protein observed spectroscopy is evaluated as a method for…”
Get full text