Search Results - "Chandler, Scott H."

Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis by Liu, Wenting, Venugopal, Sharmila, Majid, Sana, Ahn, In Sook, Diamante, Graciel, Hong, Jason, Yang, Xia, Chandler, Scott H.

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons throughout the brain and spinal cord progressively degenerate…”
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Early deficits in GABA inhibition parallels an increase in L-type Ca2+ currents in the jaw motor neurons of SOD1G93A mouse model for ALS by Venugopal, Sharmila, Ghulam-Jelani, Zohal, Ahn, In Sook, Yang, Xia, Wiedau, Martina, Simmons, Dwayne, Chandler, Scott H.

“…Amyotrophic Lateral Sclerosis (ALS) involves protracted pre-symptomatic periods of abnormal motor neuron (MN) excitability occurring in parallel with central…”
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Neuropeptide Y modulates membrane excitability in neonatal rat mesencephalic V neurons by Seki, Soju, Tanaka, Susumu, Yamada, Saori, Tsuji, Tadataka, Enomoto, Akifumi, Ono, Yudai, Chandler, Scott H., Kogo, Mikihiko

“…Neuropeptide Y (NPY) is one of a number of neuropeptides with powerful orexigenic effects. Intracerebroventricular administration of NPY induces increases in…”
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Resurgent Na+ Current Offers Noise Modulation in Bursting Neurons by Venugopal, Sharmila, Seki, Soju, Terman, David H, Pantazis, Antonios, Olcese, Riccardo, Wiedau-Pazos, Martina, Chandler, Scott H

“…Neurons utilize bursts of action potentials as an efficient and reliable way to encode information. It is likely that the intrinsic membrane properties of…”
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Persistent Sodium Currents in Mesencephalic V Neurons Participate in Burst Generation and Control of Membrane Excitability by Wu, Nanping, Enomoto, Akifumi, Tanaka, Susumu, Hsiao, Chie-Fang, Nykamp, Duane Q, Izhikevich, Eugene, Chandler, Scott H

“…1 Department of Physiological Science, University of California, Los Angeles, California; 2 1st Department of Oral and Maxillofacial Surgery, Graduate School…”
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Sodium Currents in Mesencephalic Trigeminal Neurons From Nav1.6 Null Mice by Enomoto, Akifumi, Han, Juliette M, Hsiao, Chie-Fang, Chandler, Scott H

“…1 Department of Physiological Science, University of California, Los Angeles, California; and 2 1st Department of Oral Maxillofacial Surgery, Graduate School…”
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Reflections on my longtime friendship with Mike Levine by Chandler, Scott H.

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Participation of Kv1 Channels in Control of Membrane Excitability and Burst Generation in Mesencephalic V Neurons by Hsiao, Chie-Fang, Kaur, Gurvinder, Vong, Angela, Bawa, Harpreet, Chandler, Scott H

“…Department of Physiological Science, University of California at Los Angeles, Los Angeles, California Submitted 19 September 2008; accepted in final form 5…”
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Participation of Sodium Currents in Burst Generation and Control of Membrane Excitability in Mesencephalic Trigeminal Neurons by Enomoto, Akifumi, Han, Juliette M, Hsiao, Chie-Fang, Wu, Nanping, Chandler, Scott H

“…Subthreshold sodium currents are important in sculpting neuronal discharge and have been implicated in production and/or maintenance of subthreshold membrane…”
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Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease by Starling, Amaal J., André, Véronique M., Cepeda, Carlos, de Lima, Marianne, Chandler, Scott H., Levine, Michael S.

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that affects primarily the striatum and cerebral cortex. A search for the factors…”
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Striatal Potassium Channel Dysfunction in Huntington's Disease Transgenic Mice by Ariano, Marjorie A, Cepeda, Carlos, Calvert, Christopher R, Flores-Hernandez, Jorge, Hernandez-Echeagaray, Elizabeth, Klapstein, Gloria J, Chandler, Scott H, Aronin, Neil, DiFiglia, Marian, Levine, Michael S

“…1 Mental Retardation Research Center and 2 Department of Physiological Sciences, David Geffen School of Medicine, University of California, Los Angeles,…”
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Serotonergic modulation of persistent sodium currents and membrane excitability via cyclic AMP-protein kinase A cascade in mesencephalic V neurons by Tanaka, Susumu, Chandler, Scott H.

“…In rat mesencephalic trigeminal (Mes V) neurons, persistent sodium currents in conjunction with low‐threshold potassium currents are critical for generation of…”
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Membrane Resonance and Subthreshold Membrane Oscillations in Mesencephalic V Neurons: Participants in Burst Generation by Wu, Nanping, Hsiao, Chie-Fang, Chandler, Scott H

“…Trigeminal mesencephalic (Mes V) neurons are critical components of the circuits controlling oral-motor activity. The possibility that they can function as…”
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Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1G93A Mouse Model for ALS by Seki, Soju, Yamamoto, Toru, Quinn, Kiara, Spigelman, Igor, Pantazis, Antonios, Olcese, Riccardo, Wiedau-Pazos, Martina, Chandler, Scott H, Venugopal, Sharmila

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons degenerate, resulting in muscle atrophy, paralysis, and fatality…”
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NMDA receptor function in mouse models of Huntington disease by Cepeda, Carlos, Ariano, Marjorie A., Calvert, Christopher R., Flores-Hernández, Jorge, Chandler, Scott H., Leavitt, Blair R., Hayden, Michael R., Levine, Michael S.

“…Huntington disease (HD) is an autosomal dominant disorder in which degeneration of medium‐sized spiny striatal neurons occurs. The HD gene and the protein it…”
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Dopaminergic Modulation of NMDA-Induced Whole Cell Currents in Neostriatal Neurons in Slices: Contribution of Calcium Conductances by Cepeda, Carlos, Colwell, Christopher S, Itri, Jason N, Chandler, Scott H, Levine, Michael S

“…Carlos Cepeda 1 , Christopher S. Colwell 1 , Jason N. Itri 1 , Scott H. Chandler 1 , 2 , and Michael S. Levine 1  Mental Retardation Research Center and 2…”
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Intrinsic membrane properties and morphological characteristics of interneurons in the rat supratrigeminal region by Hsiao, Chie-Fang, Gougar, Kelly, Asai, J., Chandler, Scott H.

“…The membrane properties and morphological features of interneurons in the supratrigeminal area (SupV) were studied in rat brain slices using whole‐cell patch…”
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Homeostatic dysregulation in membrane properties of masticatory motoneurons compared with oculomotor neurons in a mouse model for amyotrophic lateral sclerosis by Venugopal, Sharmila, Hsiao, Chie-Fang, Sonoda, Takuma, Wiedau-Pazos, Martina, Chandler, Scott H

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative motoneuron disease with presently no cure. Motoneuron (MN) hyperexcitability is commonly…”
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Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1 G93A Mouse Model for ALS by Seki, Soju, Yamamoto, Toru, Quinn, Kiara, Spigelman, Igor, Pantazis, Antonios, Olcese, Riccardo, Wiedau-Pazos, Martina, Chandler, Scott H, Venugopal, Sharmila

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons degenerate, resulting in muscle atrophy, paralysis, and fatality…”
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Participation of a persistent sodium current and calcium-activated nonspecific cationic current to burst generation in trigeminal principal sensory neurons by Tsuruyama, Kentaro, Hsiao, Chie-Fang, Chandler, Scott H

“…The properties of neurons participating in masticatory rhythmogenesis are not clearly understood. Neurons within the dorsal trigeminal principal sensory…”
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