Search Results - "Chandler, Darrell"

Automated TruTip nucleic acid extraction and purification from raw sputum by Thakore, Nitu, Norville, Ryan, Franke, Molly, Calderon, Roger, Lecca, Leonid, Villanueva, Michael, Murray, Megan B, Cooney, Christopher G, Chandler, Darrell P, Holmberg, Rebecca C

“…Automated nucleic acid extraction from primary (raw) sputum continues to be a significant technical challenge for molecular diagnostics. In this work, we…”
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Beyond the Usual Suspects: Examining the Role of Understudied Histone Variants in Breast Cancer by Dhahri, Hejer, Saintilnord, Wesley N, Chandler, Darrell, Fondufe-Mittendorf, Yvonne N

“…The incorporation of histone variants has structural ramifications on nucleosome dynamics and stability. Due to their unique sequences, histone variants can…”
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A Benchtop Automated Sputum-to-Genotype System Using a Lab-on-a-Film Assembly for Detection of Multidrug-Resistant Mycobacterium tuberculosis by Kukhtin, Alexander V, Norville, Ryan, Bueno, Arial, Qu, Peter, Parrish, Nicole, Murray, Megan, Chandler, Darrell P, Holmberg, Rebecca C, Cooney, Christopher G

“…Automated genotyping of drug-resistant Mycobacterium tuberculosis (MTB) directly from sputum is challenging for three primary reasons. First, the sample…”
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Bicarbonate impact on U(VI) bioreduction in a shallow alluvial aquifer by Long, Philip E., Williams, Kenneth H., Davis, James A., Fox, Patricia M., Wilkins, Michael J., Yabusaki, Steven B., Fang, Yilin, Waichler, Scott R., Berman, Elena S.F., Gupta, Manish, Chandler, Darrell P., Murray, Chris, Peacock, Aaron D., Giloteaux, Ludovic, Handley, Kim M., Lovley, Derek R., Banfield, Jillian F.

“…Field-scale biostimulation and desorption tracer experiments conducted in a uranium (U) contaminated, shallow alluvial aquifer have provided insight into the…”
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A bench-top automated workstation for nucleic acid isolation from clinical sample types by Thakore, Nitu, Garber, Steve, Bueno, Arial, Qu, Peter, Norville, Ryan, Villanueva, Michael, Chandler, Darrell P., Holmberg, Rebecca, Cooney, Christopher G.

“…Systems that automate extraction of nucleic acid from cells or viruses in complex clinical matrices have tremendous value even in the absence of an integrated…”
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Lab-on-a-Film disposable for genotyping multidrug-resistant Mycobacterium tuberculosis from sputum extracts by Kukhtin, Alexander C, Sebastian, Thomas, Golova, Julia, Perov, Alex, Knickerbocker, Christopher, Linger, Yvonne, Bueno, Arial, Qu, Peter, Villanueva, Michael, Holmberg, Rebecca C, Chandler, Darrell P, Cooney, Christopher G

“…We describe a Lab-on-a-Film disposable that detects multidrug-resistant tuberculosis (MDR-TB) from sputum extracts. The Lab-on-a-Film disposable consists of…”
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Genotyping Multidrug-Resistant Mycobacterium tuberculosis from Primary Sputum and Decontaminated Sediment with an Integrated Microfluidic Amplification Microarray Test by Linger, Yvonne, Knickerbocker, Christopher, Sipes, David, Golova, Julia, Franke, Molly, Calderon, Roger, Lecca, Leonid, Thakore, Nitu, Holmberg, Rebecca, Qu, Peter, Kukhtin, Alexander, Murray, Megan B, Cooney, Christopher G, Chandler, Darrell P

“…There is a growing awareness that molecular diagnostics for detect-to-treat applications will soon need a highly multiplexed mutation detection and…”
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Corrigendum to “A bench-top automated workstation for nucleic acid isolation from clinical sample types” [J. Microbiol. Methods 148 (2018) 174–180] by Thakore, Nitu, Garber, Steve, Bueno, Arial, Qu, Peter, Norville, Ryan, Villanueva, Michael, Chandler, Darrell P., Holmberg, Rebecca, Cooney, Christopher G.

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Simplified microarray system for simultaneously detecting rifampin, isoniazid, ethambutol, and streptomycin resistance markers in Mycobacterium tuberculosis by Linger, Yvonne, Kukhtin, Alexander, Golova, Julia, Perov, Alexander, Lambarqui, Amine, Bryant, Lexi, Rudy, George B, Dionne, Kim, Fisher, Stefanie L, Parrish, Nicole, Chandler, Darrell P

“…We developed a simplified microarray test for detecting and identifying mutations in rpoB, katG, inhA, embB, and rpsL and compared the analytical performance…”
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Independent phenotypic plasticity axes define distinct obesity sub-types by Yang, Chih-Hsiang, Fagnocchi, Luca, Apostle, Stefanos, Wegert, Vanessa, Casaní-Galdón, Salvador, Landgraf, Kathrin, Panzeri, Ilaria, Dror, Erez, Heyne, Steffen, Wörpel, Till, Chandler, Darrell P., Lu, Di, Yang, Tao, Gibbons, Elizabeth, Guerreiro, Rita, Bras, Jose, Thomasen, Martin, Grunnet, Louise G., Vaag, Allan A., Gillberg, Linn, Grundberg, Elin, Conesa, Ana, Körner, Antje, Pospisilik, J. Andrew

“…Studies in genetically ‘identical’ individuals indicate that as much as 50% of complex trait variation cannot be traced to genetics or to the environment. The…”
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Direct Detection of 16S rRNA in Soil Extracts by Using Oligonucleotide Microarrays by SMALL, Jack, CALL, Douglas R, BROCKMAN, Fred J, STRAUB, Timothy M, CHANDLER, Darrell P

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Monitoring Microbial Community Structure and Dynamics during in situ U(VI) Bioremediation with a Field-Portable Microarray Analysis System by Chandler, Darrell P, Kukhtin, Alexander, Mokhiber, Rebecca, Knickerbocker, Christopher, Ogles, Dora, Rudy, George, Golova, Julia, Long, Phil, Peacock, Aaron

“…The objective of this study was to develop and validate a simple, field-portable, microarray system for monitoring microbial community structure and dynamics…”
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Towards a unified system for detecting waterborne pathogens by Straub, Timothy M, Chandler, Darrell P

“…Currently, there is no single method to collect, process, and analyze a water sample for all pathogenic microorganisms of interest. Some of the difficulties in…”
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Profiling In Situ Microbial Community Structure with an Amplification Microarray by CHANDLER, Darrell P, KNICKERBOCKER, Christopher, BRYANT, Lexi, GOLOVA, Julia, WILES, Cory, WILLIAMS, Kenneth H, PEACOCK, Aaron D, LONG, Philip E

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Application of the 5′ Fluorogenic Exonuclease Assay (TaqMan) for Quantitative Ribosomal DNA and rRNA Analysis in Sediments by STULTS, Jennie R, SNOEYENBOS-WEST, Oona, METHE, Barbara, LOVLEY, Derek R, CHANDLER, Darrell P

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Nonvolatile copolymer compositions for fabricating gel element microarrays by Golova, Julia B., Chernov, Boris K., Perov, Alexander N., Reynolds, Jennifer, Linger, Yvonne L., Kukhtin, Alexander, Chandler, Darrell P.

“…By modifying polymer compositions and cross-linking reagents, we have developed a simple yet effective manufacturing strategy for copolymerized…”
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Detecting and genotyping Escherichia coli O157:H7 using multiplexed PCR and nucleic acid microarrays by Call, Douglas R, Brockman, Fred J, Chandler, Darrell P

“…Rapid detection and characterization of food borne pathogens such as Escherichia coli O157:H7 is crucial for epidemiological investigations and food safety…”
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Rapid, simple influenza RNA extraction from nasopharyngeal samples by Chandler, Darrell P., Griesemer, Sara B., Cooney, Christopher G., Holmberg, Rebecca, Thakore, Nitu, Mokhiber, Becca, Belgrader, Phillip, Knickerbocker, Christopher, Schied, Jeanmarie, St. George, Kirsten

“…This report describes the development and pre-clinical testing of a new, random-access RNA sample preparation system (TruTip) for nasopharyngeal samples. The…”
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Automated, simple, and efficient influenza RNA extraction from clinical respiratory swabs using TruTip and epMotion by Griesemer, Sara B, Holmberg, Rebecca, Cooney, Christopher G, Thakore, Nitu, Gindlesperger, Alissa, Knickerbocker, Christopher, Chandler, Darrell P, St. George, Kirsten

“…Abstract Background Rapid, simple and efficient influenza RNA purification from clinical samples is essential for sensitive molecular detection of influenza…”
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High-throughput, automated extraction of DNA and RNA from clinical samples using TruTip technology on common liquid handling robots by Holmberg, Rebecca C, Gindlesperger, Alissa, Stokes, Tinsley, Brady, Dane, Thakore, Nitu, Belgrader, Philip, Cooney, Christopher G, Chandler, Darrell P

“…TruTip is a simple nucleic acid extraction technology whereby a porous, monolithic binding matrix is inserted into a pipette tip. The geometry of the monolith…”
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