Search Results - "Chandiwana, Nomathemba"
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Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV
Published in The New England journal of medicine (29-08-2019)“…Treatment of HIV-1 infection in sub-Saharan Africa has many challenges. In this report, the safety and efficacy of three different regimens are assessed in…”
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Weight Gain After HIV Therapy Initiation: Pathophysiology and Implications
Published in The journal of clinical endocrinology and metabolism (18-01-2024)“…Abstract Rapid advances in the potency, safety, and availability of modern HIV antiretroviral therapy (ART) have yielded a near-normal life expectancy for most…”
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3
Impact of long-acting therapies on the global HIV epidemic
Published in AIDS (London) (15-12-2021)“…Long-acting antiretroviral drugs have emerged as exciting treatment and preexposure prophylaxis (PrEP) options for people with HIV and at risk of HIV…”
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4
Genetic Associations with Weight Gain among South Africans who Initiated Dolutegravir-Containing and Tenofovir-Containing Regimens
Published in Journal of acquired immune deficiency syndromes (1999) (01-07-2021)“…Excessive weight gain affects some HIV-positive individuals prescribed dolutegravir-containing regimens. Mechanisms underlying such weight gain are unknown…”
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Unexpected interactions between dolutegravir and folate: randomized trial evidence from South Africa
Published in AIDS (London) (02-02-2021)“…OBJECTIVE:Dolutegravir exposure at conception was associated with a preliminary signal of increased infant neural tube defect (NTD) risk. As low maternal…”
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6
Pharmacogenetics of tenofovir renal toxicity in HIV-positive Southern Africans
Published in Pharmacogenetics and genomics (01-07-2023)“…Renal toxicity is more common with tenofovir disoproxil fumarate (TDF) than with tenofovir alafenamide fumarate (TAF). We investigated whether polymorphisms in…”
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Correction: Experiences of doctoral students enrolled in a research fellowship program to support doctoral training in Africa (2014 to 2018): The Consortium for Advanced Research Training in Africa odyssey
Published in PloS one (09-02-2024)“…[This corrects the article DOI: 10.1371/journal.pone.0252863.]…”
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Community-based management of a five-arm randomised clinical trial in COVID-19 outpatients in South Africa: challenges and opportunities
Published in Current controlled trials in cardiovascular medicine (04-10-2023)“…Repeated COVID-19 waves and corresponding mitigation measures have impacted health systems globally with exceptional challenges. In response to the pandemic,…”
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Experiences of doctoral students enrolled in a research fellowship program to support doctoral training in Africa (2014 to 2018): The Consortium for Advanced Research Training in Africa odyssey
Published in PloS one (10-06-2021)“…The Consortium for Advanced Research Training in Africa (CARTA) aims to transform higher education in Africa. One of its main thrusts is supporting promising…”
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Southern African HIV Clinicians Society Guideline for the clinical management of syphilis
Published in Southern African journal of HIV medicine (2024)“…Syphilis, 'the great imitator', caused by infection, remains a complex and multifaceted disease with a rich history of clinical diversity. This guideline aims…”
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Population pharmacokinetics of tenofovir given as either tenofovir disoproxil fumarate or tenofovir alafenamide in an African population
Published in CPT: pharmacometrics and systems pharmacology (01-06-2023)“…Tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) are prodrugs of the nucleotide analogue tenofovir, which acts intracellularly to inhibit…”
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Effect of obesity on dolutegravir exposure in Black Southern African adults living with HIV
Published in Southern African journal of HIV medicine (2022)“…Dolutegravir, a component of the preferred first-line antiretroviral therapy regimen, has been associated with increased weight gain. South Africa has a high…”
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AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter
Published in Current controlled trials in cardiovascular medicine (26-07-2021)“…There is an urgent unmet clinical need for the identification of novel therapeutics for the treatment of COVID-19. A number of COVID-19 late phase trial…”
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Southern African HIV Clinicians Society 2022 guideline for the management of sexually transmitted infections: Moving towards best practice
Published in Southern African journal of HIV medicine (2022)“…Other STIs may cause serious short-term and long-term complications (e.g. pelvic inflammatory disease, arthritis, encephalitis), increase the risk of ectopic…”
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Trends in body mass index for people with and without HIV: Pooled analysis of nationally-representative health surveys from 10 countries and 173,800 adults in Africa
Published in PLOS global public health (2024)“…It remains unclear if and how body mass index (BMI) levels have changed over time in HIV endemic regions. We described trends in mean BMI and prevalence of…”
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Erratum: Southern African HIV Clinicians Society 2022 guideline for the management of sexually transmitted infections: Moving towards best practice
Published in Southern African journal of HIV medicine (2022)“…[This corrects the article DOI: 10.4102/sajhivmed.v23i1.1450.]…”
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Guidelines to support HIV-affected individuals and couples to achieve pregnancy safely : update 2018
Published in Southern African journal of HIV medicine (2018)“…In June 2011, the Southern African HIV Clinicians’ Society, together with an expert working group, developed the Guidelines on Safer Conception in Fertile…”
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Support for African clinician scientists
Published in Nature (London) (22-11-2018)Get full text
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African clinician scientists — mentors and networks help
Published in Nature (London) (01-11-2018)Get full text
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Impact of rilpivirine cross-resistance on long-acting cabotegravir-rilpivirine in low and middle income countries
Published in AIDS (London) (06-02-2023)“…Baseline rilpivirine drug resistance mutations (DRM) are a risk factor for virological failure in patients treated with long-acting cabotegravir plus…”
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