Search Results - "Chandgude, Ajay L."

Highly Diastereo‐ and Enantioselective Synthesis of Nitrile‐Substituted Cyclopropanes by Myoglobin‐Mediated Carbene Transfer Catalysis by Chandgude, Ajay L., Fasan, Rudi

“…A chemobiocatalytic strategy for the highly stereoselective synthesis of nitrile‐substituted cyclopropanes is reported. The present approach relies on an…”
Get full text

Multicomponent Reactions, Union of MCRs and Beyond by Zarganes-Tzitzikas, Tryfon, Chandgude, Ajay L., Dömling, Alexander

“…Multicomponent reactions (MCRs), which are located between one‐ and two‐component and polymerization reactions, provide a number of valuable conceptual and…”
Get full text

Convergent Three-Component Tetrazole Synthesis by Chandgude, Ajay L., Dömling, Alexander

“…A microwave‐accelerated, simple, and efficient method for the construction of the 1,5‐tetrazole scaffold was developed. It comprises a multicomponent reaction…”
Get full text

Innovative synthesis of drug-like molecules using tetrazole as core building blocks by Li, Jingyao, Chandgude, Ajay L, Zheng, Qiang, Dömling, Alexander

“…Tetrazole is widely utilized as a bioisostere for carboxylic acid in the field of medicinal chemistry and drug development, enhancing the drug-like…”
Get full text

Mechanistic Investigation of Biocatalytic Heme Carbenoid Si−H Insertions by Khade, Rahul L., Chandgude, Ajay L., Fasan, Rudi, Zhang, Yong

“…Recent studies reported the development of biocatalytic heme carbenoid Si−H insertions for the selective formation of carbon‐silicon bonds, but many…”
Get full text

Diastereoselective One Pot Five-Component Reaction toward 4-(Tetrazole)-1,3-Oxazinanes by Chandgude, Ajay L, Narducci, Daniele, Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, Dömling, Alexander

“…A diastereoselective one pot five-component reaction toward the synthesis of 4-(tetrazole)-1,3-oxazinanes has been reported. The sonication-accelerated,…”
Get full text

Stereodivergent Intramolecular Cyclopropanation Enabled by Engineered Carbene Transferases by Chandgude, Ajay L, Ren, Xinkun, Fasan, Rudi

“…We report the development of engineered myoglobin biocatalysts for executing asymmetric intramolecular cyclopropanations resulting in cyclopropane-fused…”
Get full text

Highly Stereoselective Synthesis of Fused Cyclopropane-γ-Lactams via Biocatalytic Iron-Catalyzed Intramolecular Cyclopropanation by Ren, Xinkun, Chandgude, Ajay L, Fasan, Rudi

“…We report the development of an iron-based biocatalytic strategy for the asymmetric synthesis of fused cyclopropane-γ-lactams, which are key structural motifs…”
Get full text

Highly Diastereo‐ and Enantioselective Synthesis of Nitrile‐Substituted Cyclopropanes by Myoglobin‐Mediated Carbene Transfer Catalysis by Chandgude, Ajay L., Fasan, Rudi

“…A chemobiocatalytic strategy for the highly stereoselective synthesis of nitrile‐substituted cyclopropanes is reported. The present approach relies on an…”
Get full text

An Enzymatic Platform for the Highly Enantioselective and Stereodivergent Construction of Cyclopropyl‐δ‐lactones by Ren, Xinkun, Liu, Ningyu, Chandgude, Ajay L., Fasan, Rudi

“…Abiological enzymes offers new opportunities for sustainable chemistry. Herein, we report the development of biological catalysts derived from sperm whale…”
Get full text

CuSO4–Glucose for in Situ Generation of Controlled Cu(I)–Cu(II) Bicatalysts: Multicomponent Reaction of Heterocyclic Azine and Aldehyde with Alkyne, and Cycloisomerization toward Synthesis of N-Fused Imidazoles by Guchhait, Sankar K, Chandgude, Ajay L, Priyadarshani, Garima

“…The catalytic efficiency of mixed Cu(I)–Cu(II) system in situ generated by partial reduction of CuSO4 with glucose in ethanol (nonanhydrous) under open air has…”
Get full text

Unconventional Passerini Reaction toward α‑Aminoxy-amides by Chandgude, Ajay L, Dömling, Alexander

“…The Passerini multicomponent reaction (P-3CR) toward the one-step synthesis of α-aminoxy-amide, by employing for the first time a N-hydroxamic acid component,…”
Get full text

N‑Hydroxyimide Ugi Reaction toward α‑Hydrazino Amides by Chandgude, Ajay L, Dömling, Alexander

“…The Ugi four-component reaction (U-4CR) with N-hydroxyimides as a novel carboxylic acid isostere has been reported. This reaction provides straightforward…”
Get full text

Highly stereoselective and enantiodivergent synthesis of cyclopropylphosphonates with engineered carbene transferases by Ren, Xinkun, Chandgude, Ajay L, Carminati, Daniela M, Shen, Zhuofan, Khare, Sagar D, Fasan, Rudi

“…Organophosphonate compounds have represented a rich source of biologically active compounds, including enzyme inhibitors, antibiotics, and antimalarial agents…”
Get full text

Direct Amination of α‐Hydroxy Amides by Chandgude, Ajay L., Dömling, Alexander

“…A TiCl4‐mediated reaction for the direct amination of α‐hydroxy amides has been developed. This simple, general, additive/base/ligand‐free reaction is mediated…”
Get full text

2‐Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide by Chandgude, Ajay L., Li, Jingyao, Dömling, Alexander

“…2‐Nitrobenzyl isocyanide is reported as a universal convertible isocyanide with extensive applicability in both Ugi four‐component reaction (Ugi‐4CR) and…”
Get full text

An Enzymatic Platform for the Highly Enantioselective and Stereodivergent Construction of Cyclopropyl‐δ‐lactones by Ren, Xinkun, Liu, Ningyu, Chandgude, Ajay L., Fasan, Rudi

“…Abiological enzymes offers new opportunities for sustainable chemistry. Herein, we report the development of biological catalysts derived from sperm whale…”
Get full text

CuSO 4 –Glucose for in Situ Generation of Controlled Cu(I)–Cu(II) Bicatalysts: Multicomponent Reaction of Heterocyclic Azine and Aldehyde with Alkyne, and Cycloisomerization toward Synthesis of N-Fused Imidazoles by Guchhait, Sankar K., Chandgude, Ajay L., Priyadarshani, Garima

Get full text

An enzymatic platform for the highy enantioselective and stereodivergent construction of cyclopropyl-δ-lactones by Ren, Xinkun, Liu, Ningyu, Chandgude, Ajay L., Fasan, Rudi

“…Abiological enzymes offers new opportunities for sustainable chemistry. Here we report the development of biological catalysts derived from sperm whale…”
Get full text

Direct Amination of [alpha]-Hydroxy Amides by Chandgude, Ajay L, Domling, Alexander

“…A TiCl4-mediated reaction for the direct amination of [alpha]-hydroxy amides has been developed. This simple, general, additive/base/ligand-free reaction is…”
Get full text