Recent advances in PLGA based nanocarriers for drug delivery system: a state of the art review

The biomolecules in the clinical use being delivered by the conventional mode of delivery often exhibit poor affinity. So, there is a need for a nanomedicine-based approach that could propose a promising solution to the problems coupled with conventional drug delivery. In this context, the applicati...

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Bibliographic Details
Published in:	International journal of polymeric materials Vol. 72; no. 1; pp. 49 - 78
Main Authors:	Pardeshi, Sagar R., Nikam, Aniket, Chandak, Priyanka, Mandale, Vijaya, Naik, Jitendra B., Giram, Prabhanjan S.
Format:	Journal Article
Language:	English
Published:	Philadelphia Taylor & Francis 02-01-2023 Taylor & Francis Ltd
Subjects:	Biomolecules cancer Drug carriers drug delivery Drug delivery systems Glycolic acid nanomedicines Physiochemistry PLGA State-of-the-art reviews theranostics Toxicity
Online Access:	Get full text
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Summary:	The biomolecules in the clinical use being delivered by the conventional mode of delivery often exhibit poor affinity. So, there is a need for a nanomedicine-based approach that could propose a promising solution to the problems coupled with conventional drug delivery. In this context, the application of Poly (lactic-co-glycolic acid) (PLGA) nanocarriers in drug delivery is a promising approach to achieve good biodistribution and absorption of therapeutics to the diseased site with a reduction in toxicity. This review covers various approaches to synthesize PLGA polymer, its physiochemical, biological assets, functionalized carriers for the advancement of nano delivery to the target site, and current modern approaches having the potential to deliver PLGA-based nanomedicines against a variety of diseases.
ISSN:	0091-4037 1563-535X
DOI:	10.1080/00914037.2021.1985495