Search Results - "Chandak, G. R"

Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population by CHANDAK, G. R, JANIPALLI, C. S, BHASKAR, S, KULKARNI, S. R, MOHANKRISHNA, P, HATTERSLEY, A. T, FRAYLING, T. M, YAJNIK, C. S

“…India has the greatest number of diabetic subjects in any one country, but the genetic basis of type 2 diabetes mellitus in India is poorly understood. Common…”
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Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals by Xi, B., Takeuchi, F., Chandak, G. R., Kato, N., Pan, H. W., Zhou, D. H., Pan, H. Y., Mi, J.

“…Aims/hypothesis Genome-wide association studies have shown that variants near the melanocortin 4 receptor gene ( MC4R ) (rs17782313 and rs12970134) are…”
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FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians by Yajnik, C. S, Janipalli, C. S, Bhaskar, S, Kulkarni, S. R, Freathy, R. M, Prakash, S, Mani, K. R, Weedon, M. N, Kale, S. D, Deshpande, J, Krishnaveni, G. V, Veena, S. R, Fall, C. H. D, McCarthy, M. I, Frayling, T. M, Hattersley, A. T, Chandak, G. R

“…Aims and hypothesis Variants of the FTO (fat mass and obesity associated) gene are associated with obesity and type 2 diabetes in white Europeans, but these…”
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Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis by Chandak, G R, Idris, M M, Reddy, D N, Mani, K R, Bhaskar, S, Rao, G V, Singh, L

“…Background and aims: Mutations in the cationic trypsinogen (protease, serine, 1 (trypsin 1); PRSS1) gene are causally associated with recurrent acute and…”
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Analysis of 32 common susceptibility genetic variants and their combined effect in predicting risk of Type 2 diabetes and related traits in Indians by Janipalli, C. S., Kumar, M. V. K., Vinay, D. G., Sandeep, M. N., Bhaskar, S., Kulkarni, S. R., Aruna, M., Joglekar, C. V., Priyadharshini, S., Maheshwari, N., Yajnik, C. S., Chandak, G. R.

“…Diabet. Med. 29, 121–127 (2012) Aims  Recent genome‐wide association studies have identified several Type 2 diabetes‐related loci. We investigated the effect…”
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Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs by Gupta, V., Vinay, D. G., Rafiq, S., Kranthikumar, M. V., Janipalli, C. S., Giambartolomei, C., Evans, D. M., Mani, K. R., Sandeep, M. N., Taylor, A. E., Kinra, S., Sullivan, R. M., Bowen, L., Timpson, N. J., Smith, G. D., Dudbridge, F., Prabhakaran, D., Ben-Shlomo, Y., Reddy, K. S., Ebrahim, S., Chandak, G. R.

“…Aims/hypothesis Evaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell…”
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Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis by Chandak, G R, Idris, M M, Reddy, D N, Bhaskar, S, Sriram, P V J, Singh, L

“…A genetic basis was reported in 1996 by familial linkage analysis 3- 5 and confirmed by detection of missense mutations, namely R122H and N29I, in the cationic…”
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Frequency of primary iron overload and HFE gene mutations (C282Y, H63D and S65C) in chronic liver disease patients in north India by Dhillon, Barjinderjit Kaur, Das, Reena, Garewal, Gurjeewan, Chawla, Yogesh, Dhiman, R K, Das, Ashim, Duseja, Ajay, Chandak, G R

“…To identify the frequency of iron overload and study the three mutations in the HFE gene (C282Y, H63D, and S65C) in patients with chronic liver disorders (CLD)…”
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Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier by Kranthi Kumar, M. V., Evans, D. M., Giambartolomei, C., Janipalli, C. S., Sandeep, M. N., Taylor, A. E., Vinay, D. G., Smitha, P., Gupta, V., Aruna, M., Kinra, Sanjay, Sullivan, R. M., Bowen, L., Timpson, N. J., Davey Smith, G., Dudbridge, F., Prabhakaran, D., Ben-Shlomo, Y., Reddy, K. S., Ebrahim, S., Chandak, G. R.

“…Few studies have investigated the association between genetic variation and obesity traits in Indian populations or the role of environmental factors as…”
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Identification of urinary proteins potentially associated with diabetic kidney disease by Marikanty, R, Gupta, M, Cherukuvada, SVB, Kompella, SSS, Prayaga, A, Konda, S, Polisetty, R, Idris, M, Rao, P, Chandak, G, Dakshinamurty, K

“…Diabetic nephropathy (DN) is the most common cause of chronic kidney disease. Although several parameters are used to evaluate renal damage, in many instances,…”
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Novel p.P298L SURF1 mutation in thiamine deficient Leigh syndrome patients compromises cytochrome c oxidase activity by Mani, Shalini, Chandak, G.R., Singh, Keshav K., Singh, Rajender, Rao, S. Narasimha

“…•Different novel and reported nucleotide variations were reported in thiamine responsive Leigh syndrome patients.•Following different in-silico tests, 2…”
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Molecular pathology of haemophilia B: identification of five novel mutations including a LINE 1 insertion in Indian patients by Mukherjee, S., Mukhopadhyay, A., Banerjee, D., Chandak, G. R., Ray, K.

“…Heterogeneous mutations in factor IX (FIX) gene cause haemophilia B and a large number of mutations have been characterized. However, reports on gene defects…”
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Association of common variants in/near six genes (ATP2B1, CSK, MTHFR, CYP17A1, STK39 and FGF5) with blood pressure/hypertension risk in Chinese children by Xi, B, Shen, Y, Zhao, X, Chandak, G R, Cheng, H, Hou, D, Li, Y, Ott, J, Zhang, Y, Wang, X, Mi, J

“…Recent genome-wide association studies have identified several single-nucleotide polymorphisms (SNPs) that are associated with blood pressure…”
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Mutations in anionic trypsinogen gene are not associated with tropical calcific pancreatitis by Idris, M M, Bhaskar, S, Reddy, D N, Mani, K R, Rao, G V, Singh, L, Chandak, G R

“…[...]we initially screened exons 2 and 3 of the anionic trypsinogen gene in 68 well characterised Indian patients with tropical calcific pancreatitis. 6…”
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Cardiac Beriberi: Often a Missed Diagnosis by Rao, S. Narasimha, Chandak, G. R.

“…Thiamine deficiency leads to various manifestations due to dysfunction of nervous or cardiovascular system, commonly known as dry and wet beriberi,…”
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Lack of replication of association of THSD7A with obesity by Ahmad, M, Nongmaithem, S S, Krishnaveni, G V, Fall, C H D, Yajnik, C S, Chandak, G R

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Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis by Mahurkar, S, Idris, M M, Reddy, D N, Bhaskar, S, Rao, G V, Thomas, V, Singh, L, Chandak, G R

“…Background and aims: Tropical calcific pancreatitis (TCP) is a type of chronic pancreatitis unique to countries in the tropics. Mutations in pancreatic…”
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Apolipoprotein E and Presenilin-1 Allelic Variation and Alzheimer's Disease in India by CHANDAK, G.R., SRIDEVI, M. UMA, VAS, C.J., PANIKKER, D.M., SINGH, L.

“…As part of a larger epidemiological survey to study the prevalence of dementia in a suburb of Mumbai, Western India, we identified 78 cases with a Clinical…”
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Fetus-in-fetu: A case report with molecular analysis by Kumar, A.Narendra, Chandak, G.R., Rajasekhar, A., Reddy, N.C.K., Singh, L.

“…This is the report of a case of fetus-in-fetu diagnosed in a 3-month-old boy and found to be located in the upper retroperitoneum. The entity was distinguished…”
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H63D mutation in HFE gene is common in Indians and is associated with the European haplotype by DHILLON, BARJINDERJIT KAUR, PRAKASH, SWAMI, CHANDAK, G. R., CHAWLA, Y. K., DAS, REENA

“…The common C282Y mutation (HFE gene) in hereditary hemochromatosis patients of European origin is absent in Indians. The frequency of the second common…”
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