Search Results - "Chand, Kirat K"

Early evolution of glial morphology and inflammatory cytokines following hypoxic-ischemic injury in the newborn piglet brain by Teo, Elliot J., Chand, Kirat. K., Miller, Stephanie M., Wixey, Julie A., Colditz, Paul B., Bjorkman, S. Tracey

“…Neuroinflammation is a hallmark of hypoxic-ischemic injury and can be characterized by the activation of glial cells and the expression of inflammatory…”
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Neuropathology in intrauterine growth restricted newborn piglets is associated with glial activation and proinflammatory status in the brain by Wixey, Julie A, Lee, Kah Meng, Miller, Stephanie M, Goasdoue, Kate, Colditz, Paul B, Tracey Bjorkman, S, Chand, Kirat K

“…The fetal brain is particularly vulnerable to intrauterine growth restriction (IUGR) conditions evidenced by neuronal and white matter abnormalities and…”
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Author Correction: Tick holocyclotoxins trigger host paralysis by presynaptic inhibition by Chand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A., Rodriguez-Valle, Manuel, Ijaz, Hina, Koehbach, Johannes, Clark, Richard J., Lew-Tabor, Ala, Noakes, Peter G.

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Ibuprofen Treatment Reduces the Neuroinflammatory Response and Associated Neuronal and White Matter Impairment in the Growth Restricted Newborn by Wixey, Julie A, Sukumar, Kishen R, Pretorius, Rinaldi, Lee, Kah Meng, Colditz, Paul B, Bjorkman, S Tracey, Chand, Kirat K

“…Intrauterine growth restriction (IUGR) is a condition where the fetus does not achieve optimal growth, commonly caused by placental insufficiency. The chronic…”
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Tick holocyclotoxins trigger host paralysis by presynaptic inhibition by Chand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A., Rodriguez-Valle, Manuel, Ijaz, Hina, Koehbach, Johannes, Clark, Richard J., Lew-Tabor, Ala, Noakes, Peter G.

“…Ticks are important vectors of pathogens and secreted neurotoxins with approximately 69 out of 692 tick species having the ability to induce severe toxicoses…”
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The search for blood biomarkers that indicate risk of adverse neurodevelopmental outcomes in fetal growth restriction by Musco, Hannah, Beecher, Kate, Chand, Kirat K, Boyd, Roslyn N, Colditz, Paul B, Wixey, Julie A

“…Fetal growth restriction (FGR) impacts 5%-10% of pregnancies and is associated with increased risk of mortality and morbidity. Although adverse…”
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Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn by Chand, Kirat K., Patel, Jatin, Bjorkman, S. T., Sim, Seen-Ling, Miller, Stephanie M., Teo, Elliot, Jones, Lara, Sun, Jane, Colditz, Paul B., Khosrotehrani, Kiarash, Wixey, Julie A.

“…The foetal brain is particularly vulnerable to the detrimental effects of foetal growth restriction (FGR) with subsequent abnormal neurodevelopment being…”
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Review: Neuroinflammation in intrauterine growth restriction by Wixey, Julie A, Chand, Kirat K, Colditz, Paul B, Bjorkman, S. Tracey

“…Abstract Disruption to the maternal environment during pregnancy from events such as hypoxia, stress, toxins, inflammation, and reduced placental blood flow…”
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Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP‐43Q331K transgenic mouse model of amyotrophic lateral sclerosis by Chand, Kirat K., Lee, Kah Meng, Lee, John D., Qiu, Hao, Willis, Emily F., Lavidis, Nickolas A., Hilliard, Massimo A., Noakes, Peter G.

“…Transactive response DNA‐binding protein‐43 (TDP‐43) is involved in gene regulation via the control of RNA transcription, splicing, and transport. TDP‐43 is a…”
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Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets by Wu, Bing Anthony, Chand, Kirat K., Bell, Alexander, Miller, Suzanne L., Colditz, Paul B., Malhotra, Atul, Wixey, Julie A.

“…The neurovascular unit (NVU) within the brain is a multicellular unit that synergistically acts to maintain blood–brain barrier function and meet cerebral…”
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CSF1R inhibition promotes neuroinflammation and behavioral deficits during graft-versus-host disease in mice by Adams, Rachael C., Carter-Cusack, Dylan, Llanes, Genesis T., Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc J., Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R., Furlan, Scott N., Zeiser, Robert, MacDonald, Kelli P. A.

“…•Antibody-mediated CSF1R inhibition is associated with neurological toxicity during acute and chronic CNS GVHD.•Targeting donor IFNGR signaling is a promising…”
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Therapeutic potential to reduce brain injury in growth restricted newborns by Wixey, Julie A., Chand, Kirat K., Pham, Lily, Colditz, Paul B., Bjorkman, S. Tracey

“…Brain injury in intrauterine growth restricted (IUGR) infants is a major contributing factor to morbidity and mortality worldwide. Adverse outcomes range from…”
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Loss of laminin-α4 results in pre- and postsynaptic modifications at the neuromuscular junction by Chand, Kirat K, Lee, Kah Meng, Lavidis, Nickolas A, Noakes, Peter G

“…Synaptic basal lamina such as laminin-421 (α4β2γ1) mediate differentiation of the neuromuscular junction (NMJ). Laminins interact with their pre- or…”
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Neurovascular Unit Alterations in the Growth-Restricted Newborn Are Improved Following Ibuprofen Treatment by Chand, Kirat K., Miller, Stephanie M., Cowin, Gary J., Mohanty, Lipsa, Pienaar, Jany, Colditz, Paul B., Bjorkman, Stella Tracey, Wixey, Julie A.

“…The developing brain is particularly vulnerable to foetal growth restriction (FGR) and abnormal neurodevelopment is common in the FGR infant ranging from…”
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Loss of β2‐laminin alters calcium sensitivity and voltage‐gated calcium channel maturation of neurotransmission at the neuromuscular junction by Chand, Kirat K., Lee, Kah Meng, Schenning, Mitja P., Lavidis, Nickolas A., Noakes, Peter G.

“…Key points Neuromuscular junctions from β2‐laminin‐deficient mice exhibit lower levels of calcium sensitivity. Loss of β2‐laminin leads to a failure in…”
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Neonatal seizures are associated with redistribution and loss of GABAA α‐subunits in the hypoxic‐ischaemic pig by Miller, Stephanie M., Sullivan, Susan M., Ireland, Zoe, Chand, Kirat K., Colditz, Paul B., Bjorkman, S. Tracey

“…Seizures are a common manifestation of hypoxic‐ischaemic brain injury in the neonate. In status epilepticus models alterations to GABAAR subunit expression…”
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Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression by Lee, Kah Meng, Chand, Kirat K, Hammond, Luke A, Lavidis, Nickolas A, Noakes, Peter G

“…Laminin-α4 is involved in the alignment of active zones to postjunctional folds at the neuromuscular junction (NMJ). Prior study has implicated laminin-α4 in…”
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Disruption to the 5-HT7 Receptor Following Hypoxia–Ischemia in the Immature Rodent Brain by Wixey, Julie A., Reinebrant, Hanna E., Chand, Kirat K., Buller, Kathryn M.

“…It has become increasingly evident the serotonergic (5-hydroxytryptamine, 5-HT) system is an important central neuronal network disrupted following neonatal…”
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Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP-43 Q331K transgenic mouse model of amyotrophic lateral sclerosis by Chand, Kirat K, Lee, Kah Meng, Lee, John D, Qiu, Hao, Willis, Emily F, Lavidis, Nickolas A, Hilliard, Massimo A, Noakes, Peter G

“…Transactive response DNA-binding protein-43 (TDP-43) is involved in gene regulation via the control of RNA transcription, splicing, and transport. TDP-43 is a…”
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Neonatal seizures are associated with redistribution and loss of GABA A α-subunits in the hypoxic-ischaemic pig by Miller, Stephanie M, Sullivan, Susan M, Ireland, Zoe, Chand, Kirat K, Colditz, Paul B, Bjorkman, S Tracey

“…Seizures are a common manifestation of hypoxic-ischaemic brain injury in the neonate. In status epilepticus models alterations to GABA R subunit expression…”
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