Search Results - "Chan, Wan‐Mui"

SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells by Zhao, Hanjun, Lu, Lu, Peng, Zheng, Chen, Lin-Lei, Meng, Xinjin, Zhang, Chuyuan, Ip, Jonathan Daniel, Chan, Wan-Mui, Chu, Allen Wing-Ho, Chan, Kwok-Hung, Jin, Dong-Yan, Chen, Honglin, Yuen, Kwok-Yung, To, Kelvin Kai-Wang

“…The novel SARS-CoV-2 Omicron variant (B.1.1.529), first found in early November 2021, has sparked considerable global concern and it has >50 mutations, many of…”
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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster by Chan, Jasper Fuk-Woo, Yuan, Shuofeng, Kok, Kin-Hang, To, Kelvin Kai-Wang, Chu, Hin, Yang, Jin, Xing, Fanfan, Liu, Jieling, Yip, Cyril Chik-Yan, Poon, Rosana Wing-Shan, Tsoi, Hoi-Wah, Lo, Simon Kam-Fai, Chan, Kwok-Hung, Poon, Vincent Kwok-Man, Chan, Wan-Mui, Ip, Jonathan Daniel, Cai, Jian-Piao, Cheng, Vincent Chi-Chung, Chen, Honglin, Hui, Christopher Kim-Ming, Yuen, Kwok-Yung

“…An ongoing outbreak of pneumonia associated with a novel coronavirus was reported in Wuhan city, Hubei province, China. Affected patients were geographically…”
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Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study by To, Kelvin Kai-Wang, Tsang, Owen Tak-Yin, Leung, Wai-Shing, Tam, Anthony Raymond, Wu, Tak-Chiu, Lung, David Christopher, Yip, Cyril Chik-Yan, Cai, Jian-Piao, Chan, Jacky Man-Chun, Chik, Thomas Shiu-Hong, Lau, Daphne Pui-Ling, Choi, Chris Yau-Chung, Chen, Lin-Lei, Chan, Wan-Mui, Chan, Kwok-Hung, Ip, Jonathan Daniel, Ng, Anthony Chin-Ki, Poon, Rosana Wing-Shan, Luo, Cui-Ting, Cheng, Vincent Chi-Chung, Chan, Jasper Fuk-Woo, Hung, Ivan Fan-Ngai, Chen, Zhiwei, Chen, Honglin, Yuen, Kwok-Yung

“…Coronavirus disease 2019 (COVID-19) causes severe community and nosocomial outbreaks. Comprehensive data for serial respiratory viral load and serum antibody…”
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Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility by Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Lee, Andrew Chak-Yiu, Chan, Wan-Mui, Fan, Zhimeng, Tsoi, Hoi-Wah, Wen, Lei, Liang, Ronghui, Cao, Jianli, Chen, Yanxia, Tang, Kaiming, Luo, Cuiting, Cai, Jian-Piao, Kok, Kin-Hang, Chu, Hin, Chan, Kwok-Hung, Sridhar, Siddharth, Chen, Zhiwei, Chen, Honglin, To, Kelvin Kai-Wang, Yuen, Kwok-Yung

“…Abstract Background A physiological small-animal model that resembles COVID-19 with low mortality is lacking. Methods Molecular docking on the binding between…”
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Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing by To, Kelvin Kai-Wang, Hung, Ivan Fan-Ngai, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Chan, Wan-Mui, Tam, Anthony Raymond, Fong, Carol Ho-Yan, Yuan, Shuofeng, Tsoi, Hoi-Wah, Ng, Anthony Chin-Ki, Lee, Larry Lap-Yip, Wan, Polk, Tso, Eugene Yuk-Keung, To, Wing-Kin, Tsang, Dominic Ngai-Chong, Chan, Kwok-Hung, Huang, Jian-Dong, Kok, Kin-Hang, Cheng, Vincent Chi-Chung, Yuen, Kwok-Yung

“…Abstract Background Waning immunity occurs in patients who have recovered from Coronavirus Disease 2019 (COVID-19). However, it remains unclear whether true…”
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Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine Recipients by Lu, Lu, Mok, Bobo Wing Yee, Chen, Lin Lei, Chan, Jacky Man Chun, Tsang, Owen Tak Yin, Lam, Bosco Hoi Shiu, Chuang, Vivien Wai Man, Chu, Allen Wing Ho, Chan, Wan Mui, Ip, Jonathan Daniel, Chan, Brian Pui Chun, Zhang, Ruiqi, Yip, Cyril Chik Yan, Cheng, Vincent Chi Chung, Chan, Kwok Hung, Jin, Dong Yan, Hung, Ivan Fan Ngai, Yuen, Kwok Yung, Chen, Honglin, To, Kelvin Kai Wang

“…Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant, designated as a variant of concern by the World Health…”
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Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2 by Zhao, Hanjun, To, Kelvin K. W., Lam, Hoiyan, Zhou, Xinxin, Chan, Jasper Fuk-Woo, Peng, Zheng, Lee, Andrew C. Y., Cai, Jianpiao, Chan, Wan-Mui, Ip, Jonathan Daniel, Chan, Chris Chung-Sing, Yeung, Man Lung, Zhang, Anna Jinxia, Chu, Allen Wing Ho, Jiang, Shibo, Yuen, Kwok-Yung

“…Up to date, effective antivirals have not been widely available for treating COVID-19. In this study, we identify a dual-functional cross-linking peptide 8P9R…”
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Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters by Yuan, Shuofeng, Ye, Zi-Wei, Liang, Ronghui, Tang, Kaiming, Zhang, Anna Jinxia, Lu, Gang, Ong, Chon Phin, Man Poon, Vincent Kwok, Chan, Chris Chung-Sing, Mok, Bobo Wing-Yee, Qin, Zhenzhi, Xie, Yubin, Chu, Allen Wing-Ho, Chan, Wan-Mui, Ip, Jonathan Daniel, Sun, Haoran, Tsang, Jessica Oi-Ling, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Lu, Lu, Yip, Cyril Chik-Yan, Chu, Hin, To, Kelvin Kai-Wang, Chen, Honglin, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo

“…The in vivo pathogenicity, transmissibility, and fitness of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant are…”
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Contribution of low population immunity to the severe Omicron BA.2 outbreak in Hong Kong by Chen, Lin-Lei, Abdullah, Syed Muhammad Umer, Chan, Wan-Mui, Chan, Brian Pui-Chun, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Lu, Lu, Zhang, Xiaojuan, Zhao, Yan, Chuang, Vivien Wai-Man, Au, Albert Ka-Wing, Cheng, Vincent Chi-Chung, Sridhar, Siddharth, Yuen, Kwok-Yung, Hung, Ivan Fan-Ngai, Chan, Kwok-Hung, To, Kelvin Kai-Wang

“…Monitoring population protective immunity against SARS-CoV-2 variants is critical for risk assessment. We hypothesize that Hong Kong’s explosive Omicron BA.2…”
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Rat Hepatitis E Virus as Cause of Persistent Hepatitis after Liver Transplant by Sridhar, Siddharth, Yip, Cyril C Y, Wu, Shusheng, Cai, Jianpiao, Zhang, Anna Jin-Xia, Leung, Kit-Hang, Chung, Tom W H, Chan, Jasper F W, Chan, Wan-Mui, Teng, Jade L L, Au-Yeung, Rex K H, Cheng, Vincent C C, Chen, Honglin, Lau, Susanna K P, Woo, Patrick C Y, Xia, Ning-Shao, Lo, Chung-Mau, Yuen, Kwok-Yung

“…All hepatitis E virus (HEV) variants reported to infect humans belong to the species Orthohepevirus A (HEV-A). The zoonotic potential of the species…”
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Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study by Chu, Hin, Chan, Jasper Fuk-Woo, Yuen, Terrence Tsz-Tai, Shuai, Huiping, Yuan, Shuofeng, Wang, Yixin, Hu, Bingjie, Yip, Cyril Chik-Yan, Tsang, Jessica Oi-Ling, Huang, Xiner, Chai, Yue, Yang, Dong, Hou, Yuxin, Chik, Kenn Ka-Heng, Zhang, Xi, Fung, Agnes Yim-Fong, Tsoi, Hoi-Wah, Cai, Jian-Piao, Chan, Wan-Mui, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Zhou, Jie, Lung, David Christopher, Kok, Kin-Hang, To, Kelvin Kai-Wang, Tsang, Owen Tak-Yin, Chan, Kwok-Hung, Yuen, Kwok-Yung

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. SARS-CoV-2 is efficiently transmitted from person to…”
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Amplification‐Free, Sequencing‐Free, Detection of Viral RNAs with Variant Specification by Discrete Nanocounting by Wang, Zixun, Zhao, Xi, Chan, Wan‐Mui, Ji, Xianglin, Huang, Linfeng, Xie, Xi, Li, Wei, Zhang, Wenjun, To, Kelvin Kai‐Wang, Shi, Peng

“…This study describes an amplification‐free, sequencing‐free platform (NanoPick‐array) for fast analysis of viral RNAs. The platform combines selective…”
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Emerging SARS-CoV-2 variants expand species tropism to murines by Shuai, Huiping, Chan, Jasper Fuk-Woo, Yuen, Terrence Tsz-Tai, Yoon, Chaemin, Hu, Jing-Chu, Wen, Lei, Hu, Bingjie, Yang, Dong, Wang, Yixin, Hou, Yuxin, Huang, Xiner, Chai, Yue, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lu, Lu, Zhang, Rui-Qi, Chan, Wan-Mui, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Hu, Ye-Fan, Cai, Jian-Piao, Chan, Kwok-Hung, Zhou, Jie, Sridhar, Siddharth, Zhang, Bao-Zhong, Yuan, Shuofeng, Zhang, Anna Jinxia, Huang, Jian-Dong, To, Kelvin Kai-Wang, Yuen, Kwok-Yung, Chu, Hin

“…Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging SARS-CoV-2 variants, including B.1.1.7, B.1.351, P.1, and P.3, contain mutations in spike…”
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Multimodal investigation of rat hepatitis E virus antigenicity: Implications for infection, diagnostics, and vaccine efficacy by Sridhar, Siddharth, Situ, Jianwen, Cai, Jian-Piao, Yip, Cyril Chik-Yan, Wu, Shusheng, Zhang, Anna Jin-Xia, Wen, Lei, Chew, Nicholas Foo-Siong, Chan, Wan-Mui, Poon, Rosana Wing-Shan, Chan, Jasper Fuk-Woo, Tsang, Dominic Ngai-Chong, Chen, Honglin, Xia, Ning-Shao, Yuen, Kwok-Yung

“…Rat hepatitis E virus (Orthohepevirus species C; HEV-C1) is an emerging cause of viral hepatitis in humans. HEV-C1 is divergent from other HEV variants…”
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Development and Evaluation of an In-House Real-Time RT-PCR Targeting nsp10 Gene for SARS-CoV-2 Detection by Yip, Cyril Chik-Yan, Poon, Jane Hau-Ching, Leung, Kit-Hang, Chan, Wan-Mui, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Cheng, Vincent Chi-Chung, Yuen, Kwok-Yung, To, Kelvin Kai-Wang

“…The emergence of SARS-CoV-2 mutations poses significant challenges to diagnostic tests, as these mutations can reduce the sensitivity of commonly used RT-PCR…”
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Identification of nsp1 gene as the target of SARS‐CoV‐2 real‐time RT‐PCR using nanopore whole‐genome sequencing by Chan, Wan‐Mui, Ip, Jonathan Daniel, Chu, Allen Wing‐Ho, Yip, Cyril Chik‐Yan, Lo, Lap‐Sum, Chan, Kwok‐Hung, Ng, Anthony Chin‐Ki, Poon, Rosana Wing‐Shan, To, Wing‐Kin, Tsang, Owen Tak‐Yin, Leung, Wai‐Shing, Kwan, Mike Yat‐Wah, Chua, Gilbert T., Chung, Tom Wai‐Hin, Hung, Ivan Fan‐Ngai, Kok, Kin‐Hang, Cheng, Vincent Chi‐Chung, Chan, Jasper Fuk‐Woo, Yuen, Kwok‐Yung, To, Kelvin Kai‐Wang

“…Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has caused the coronavirus disease 2019 (COVID‐19) pandemic. Accurate detection of SARS‐CoV‐2…”
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Humoral and cellular immunity against different SARS-CoV-2 variants in patients with chronic kidney disease by Yap, Desmond Yat-Hin, Fong, Carol Ho-Yan, Zhang, Xiaojuan, Ip, Jonathan Daniel, Chan, Wan-Mui, Chu, Allen Wing-Ho, Chen, Lin-Lei, Zhao, Yan, Chan, Brian Pui-Chun, Luk, Kristine Shik, Cheng, Vincent Chi-Chung, Chan, Tak-Mao, To, Kelvin Kai-Wang

“…Chronic kidney disease (CKD) patients are at higher risk of severe COVID-19. Humoral and cellular immunity from prior infection or vaccination are important…”
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Transmission of Omicron (B.1.1.529) - SARS-CoV-2 Variant of Concern in a designated quarantine hotel for travelers: a challenge of elimination strategy of COVID-19 by Wong, Shuk-Ching, Au, Albert Ka-Wing, Chen, Hong, Yuen, Lithia Lai-Ha, Li, Xin, Lung, David Christopher, Chu, Allen Wing-Ho, Ip, Jonathan Daniel, Chan, Wan-Mui, Tsoi, Hoi-Wah, To, Kelvin Kai-Wang, Yuen, Kwok-Yung, Cheng, Vincent Chi-Chung

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SARS-CoV-2 IgG seropositivity after the severe Omicron wave of COVID-19 in Hong Kong by Poon, Rosana Wing-Shan, Chan, Brian Pui-Chun, Chan, Wan-Mui, Fong, Carol Ho-Yan, Zhang, Xiaojuan, Lu, Lu, Chen, Lin-Lei, Lam, Joy-Yan, Cheng, Vincent Chi-Chung, Wong, Samson S. Y., Kok, Kin-Hang, Yuen, Kwok-Yung, To, Kelvin Kai-Wang

“…The SARS-CoV-2 Omicron variant has led to a major wave of COVID-19 in Hong Kong between January and May 2022. Here, we used seroprevalence to estimate the…”
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Co-circulation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong by Kok, Kin-Hang, Wong, Shuk-Ching, Chan, Wan-Mui, Wen, Lei, Chu, Allen Wing-Ho, Ip, Jonathan Daniel, Lee, Lam-Kwong, Wong, Ivan Tak-Fai, Lo, Hazel Wing-Hei, Cheng, Vincent Chi-Chung, Ho, Alex Yat-Man, Lam, Bosco Hoi-Shiu, Tse, Herman, Lung, David, Ng, Ken Ng Ho-Leung, Au, Albert Ka-Wing, Siu, Gilman Kit-Hang, Yuen, Kwok-Yung

“…During the investigation of a pet shop outbreak of severe acute respiratory coronavirus 2 (SARS-CoV-2) with probable hamster-to-human transmission, the…”
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