Search Results - "Chan, Wallace K. B."

The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma by Vo, Josh N., Wu, Yi-Mi, Mishler, Jeanmarie, Hall, Sarah, Mannan, Rahul, Wang, Lisha, Ning, Yu, Zhou, Jin, Hopkins, Alexander C., Estill, James C., Chan, Wallace K. B., Yesil, Jennifer, Cao, Xuhong, Rao, Arvind, Tsodikov, Alexander, Talpaz, Moshe, Cole, Craig E., Ye, Jing C., Bergsagel, P. Leif, Auclair, Daniel, Cho, Hearn Jay, Robinson, Dan R., Chinnaiyan, Arul M.

“…Multiple myeloma is the second most common hematological malignancy. Despite significant advances in treatment, relapse is common and carries a poor prognosis…”
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In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs by Chan, Wallace K. B., Olson, Keith M., Wotring, Jesse W., Sexton, Jonathan Z., Carlson, Heather A., Traynor, John R.

“…The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires treatments with rapid clinical translatability. Here we…”
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Ontological modeling and analysis of experimentally or clinically verified drugs against coronavirus infection by Liu, Yingtong, Hur, Junguk, Chan, Wallace K. B., Wang, Zhigang, Xie, Jiangan, Sun, Duxin, Handelman, Samuel, Sexton, Jonathan, Yu, Hong, He, Yongqun

“…Our systematic literature collection and annotation identified 106 chemical drugs and 31 antibodies effective against the infection of at least one human…”
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Computational Identification of Possible Allosteric Sites and Modulators of the SARS-CoV‑2 Main Protease by DasGupta, Debarati, Chan, Wallace K. B, Carlson, Heather A

“…In this study, we target the main protease (Mpro) of the SARS-CoV-2 virus as it is a crucial enzyme for viral replication. Herein, we report three plausible…”
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GLASS: a comprehensive database for experimentally validated GPCR-ligand associations by Chan, Wallace K B, Zhang, Hongjiu, Yang, Jianyi, Brender, Jeffrey R, Hur, Junguk, Özgür, Arzucan, Zhang, Yang

“…G protein-coupled receptors (GPCRs) are probably the most attractive drug target membrane proteins, which constitute nearly half of drug targets in the…”
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Homologous G Protein-Coupled Receptors Boost the Modeling and Interpretation of Bioactivities of Ligand Molecules by Wu, Jiansheng, Sun, Yi, Chan, Wallace K.B, Zhu, Yanxiang, Zhu, Wenyong, Huang, Wanqing, Hu, Haifeng, Yan, Shancheng, Pang, Tao, Ke, Xiaoyan, Li, Fei

“…G protein-coupled receptors (GPCRs) are one of the most important drug targets, accounting for ∼34% of drugs on the market. For drug discovery, accurate…”
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Virtual Screening of Human Class-A GPCRs Using Ligand Profiles Built on Multiple Ligand–Receptor Interactions by Chan, Wallace K.B., Zhang, Yang

“…G protein-coupled receptors (GPCRs) are a large family of integral membrane proteins responsible for cellular signal transductions. Identification of…”
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WDL-RF: predicting bioactivities of ligand molecules acting with G protein-coupled receptors by combining weighted deep learning and random forest by Wu, Jiansheng, Zhang, Qiuming, Wu, Weijian, Pang, Tao, Hu, Haifeng, Chan, Wallace K B, Ke, Xiaoyan, Zhang, Yang

“…Abstract Motivation Precise assessment of ligand bioactivities (including IC50, EC50, Ki, Kd, etc.) is essential for virtual screening and lead compound…”
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Application of Mixed-Solvent Molecular Dynamics Simulations for Prediction of Allosteric Sites on G Protein-Coupled Receptors by Chan, Wallace K B, Carlson, Heather A, Traynor, John R

“…The development of small molecule allosteric modulators acting at G protein-coupled receptors (GPCRs) is becoming increasingly attractive. Such compounds have…”
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Mixed‐solvent molecular dynamics simulation‐based discovery of a putative allosteric site on regulator of G protein signaling 4 by Chan, Wallace K. B., DasGupta, Debarati, Carlson, Heather A., Traynor, John R.

“…Regulator of G protein signaling 4 (RGS4) is an intracellular protein that binds to the Gα subunit ofheterotrimeric G proteins and aids in terminating G…”
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Precise modelling and interpretation of bioactivities of ligands targeting G protein-coupled receptors by Wu, Jiansheng, Liu, Ben, Chan, Wallace K B, Wu, Weijian, Pang, Tao, Hu, Haifeng, Yan, Shancheng, Ke, Xiaoyan, Zhang, Yang

“…Abstract Motivation Accurate prediction and interpretation of ligand bioactivities are essential for virtual screening and drug discovery. Unfortunately, many…”
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N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase by Chan, Wallace K.B., Chen, Vicky P., Luk, Wilson K.W., Choi, Roy C.Y., Tsim, Karl W.K.

“…► PRiMA is a glycoprotein containing a single N-glycosylation site at asparagin-43. ► N-glycosylation of PRiMA is not essential for the formation of G4 AChE. ►…”
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The assembly of proline-rich membrane anchor (PRiMA)-linked acetylcholinesterase enzyme: glycosylation is required for enzymatic activity but not for oligomerization by Chen, Vicky P, Choi, Roy C Y, Chan, Wallace K B, Leung, K Wing, Guo, Ava J Y, Chan, Gallant K L, Luk, Wilson K W, Tsim, Karl W K

“…Acetylcholinesterase (AChE) anchors onto cell membranes by a transmembrane protein PRiMA (proline-rich membrane anchor) as a tetrameric form in vertebrate…”
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Targeting Acetylcholinesterase to Membrane Rafts: A FUNCTION MEDIATED BY THE PROLINE-RICH MEMBRANE ANCHOR (PRiMA) IN NEURONS by Xie, Heidi Q, Liang, Dong, Leung, K. Wing, Chen, Vicky P, Zhu, Kevin Y, Chan, Wallace K.B, Choi, Roy C.Y, Massoulié, Jean, Tsim, Karl W.K

“…In the mammalian brain, acetylcholinesterase (AChE) is anchored in cell membranes by a transmembrane protein PRiMA (proline-rich membrane anchor). We present…”
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PRiMA-linked Cholinesterase Tetramers Are Assembled from Homodimers: HYBRID MOLECULES COMPOSED OF ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE DIMERS ARE UP-REGULATED DURING DEVELOPMENT OF CHICKEN BRAIN by Chen, Vicky P, Xie, Heidi Q, Chan, Wallace K.B, Leung, K. Wing, Chan, Gallant K.L, Choi, Roy C.Y, Bon, Suzanne, Massoulié, Jean, Tsim, Karl W.K

“…Acetylcholinesterase (AChE) is anchored onto cell membranes by the transmembrane protein PRiMA (proline-rich membrane anchor) as a tetrameric globular form…”
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Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation by Chen, Vicky P, Luk, Wilson K W, Chan, Wallace K B, Leung, K Wing, Guo, Ava J Y, Chan, Gallant K L, Xu, Sherry L, Choi, Roy C Y, Tsim, Karl W K

“…Acetylcholinesterase (AChE) is responsible for the hydrolysis of the neurotransmitter, acetylcholine, in the nervous system. The functional localization and…”
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An induction effect of heat shock on the transcript of globular acetylcholinesterase in NG108-15 cells by Chen, Vicky P., Xie, Heidi Q., Chan, Wallace K.B., Leung, K. Wing, Choi, Roy C.Y., Tsim, Karl W.K.

“…Heat shock response, an induced transcription of a set of genes in response to high temperature, occurs in all organisms. In neurons, the catalytic subunit of…”
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Targeting Acetylcholinesterase to Membrane Rafts by Xie, Heidi Q., Liang, Dong, Leung, K. Wing, Chen, Vicky P., Zhu, Kevin Y., Chan, Wallace K.B., Choi, Roy C.Y., Massoulié, Jean, Tsim, Karl W.K.

“…In the mammalian brain, acetylcholinesterase (AChE) is anchored in cell membranes by a transmembrane protein PRiMA (proline-rich membrane anchor). We present…”
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