Search Results - "Chan, Wai Y"

Genome Data Provides High Support for Generic Boundaries in Burkholderia Sensu Lato by Beukes, Chrizelle W, Palmer, Marike, Manyaka, Puseletso, Chan, Wai Y, Avontuur, Juanita R, van Zyl, Elritha, Huntemann, Marcel, Clum, Alicia, Pillay, Manoj, Palaniappan, Krishnaveni, Varghese, Neha, Mikhailova, Natalia, Stamatis, Dimitrios, Reddy, T B K, Daum, Chris, Shapiro, Nicole, Markowitz, Victor, Ivanova, Natalia, Kyrpides, Nikos, Woyke, Tanja, Blom, Jochen, Whitman, William B, Venter, Stephanus N, Steenkamp, Emma T

“…Although the taxonomy of has been extensively scrutinized, significant uncertainty remains regarding the generic boundaries and composition of this large and…”
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Direct Phosphorylation and Regulation of Poly(ADP-Ribose) Polymerase-1 by Extracellular Signal-Regulated Kinases 1/2 by Kauppinen, Tiina M., Chan, Wai Y., Suh, Sang Won, Wiggins, Amanda K., Huang, Eric J., Swanson, Raymond A.

“…Sustained activation of poly(ADP-ribose) polymerase-1 (PARP-1) and extracellular signal-regulated kinases 1/2 (ERK1/2) both promote neuronal death. Here we…”
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South African Buffalo-Derived Theileria parva Is Distinct From Other Buffalo and Cattle-Derived T. parva by Maboko, Boitumelo B., Sibeko-Matjila, Kgomotso P., Pierneef, Rian, Chan, Wai Y., Josemans, Antoinette, Marumo, Ratselane D., Mbizeni, Sikhumbuzo, Latif, Abdalla A., Mans, Ben J.

“…Theileria parva is a protozoan parasite transmitted by the brown-eared ticks, Rhipicephalus appendiculatus and Rhipicephalus zambeziensis . Buffaloes are the…”
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Characterization of PCS1055, a novel muscarinic M4 receptor antagonist by Croy, Carrie H., Chan, Wai Y., Castetter, Andrea M., Watt, Marla L., Quets, Anne T., Felder, Christian C.

“…Identification of synthetic ligands selective for muscarinic receptor subtypes has been challenging due to the high sequence identity and structural homology…”
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Randomized Phase II Study Evaluating Akt Blockade with Ipatasertib, in Combination with Abiraterone, in Patients with Metastatic Prostate Cancer with and without PTEN Loss by de Bono, Johann S, De Giorgi, Ugo, Rodrigues, Daniel Nava, Massard, Christophe, Bracarda, Sergio, Font, Albert, Arranz Arija, Jose Angel, Shih, Kent C, Radavoi, George Daniel, Xu, Na, Chan, Wai Y, Ma, Han, Gendreau, Steven, Riisnaes, Ruth, Patel, Premal H, Maslyar, Daniel J, Jinga, Viorel

“…PI3K-Akt-mTOR and androgen receptor (AR) signaling are commonly aberrantly activated in metastatic castration-resistant prostate cancer (mCRPC), with PTEN loss…”
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A randomized phase 3 trial of zanubrutinib vs ibrutinib in symptomatic Waldenström macroglobulinemia: the ASPEN study by Tam, Constantine S., Opat, Stephen, D'Sa, Shirley, Jurczak, Wojciech, Lee, Hui-Peng, Cull, Gavin, Owen, Roger G., Marlton, Paula, Wahlin, Björn E., Sanz, Ramón Garcia, McCarthy, Helen, Mulligan, Stephen, Tedeschi, Alessandra, Castillo, Jorge J., Czyz, Jaroslaw, Fernández de Larrea, Carlos, Belada, David, Libby, Edward, Matous, Jeffrey V., Motta, Marina, Siddiqi, Tanya, Tani, Monica, Trneny, Marek, Minnema, Monique C., Buske, Christian, Leblond, Veronique, Trotman, Judith, Chan, Wai Y., Schneider, Jingjing, Ro, Sunhee, Cohen, Aileen, Huang, Jane, Dimopoulos, Meletios

“…Bruton tyrosine kinase (BTK) inhibition is an effective treatment approach for patients with Waldenström macroglobulinemia (WM). The phase 3 ASPEN study…”
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Corrigendum: Genome Data Provides High Support for Generic Boundaries in Burkholderia Sensu Lato by Beukes, Chrizelle W, Palmer, Marike, Manyaka, Puseletso, Chan, Wai Y, Avontuur, Juanita R, van Zyl, Elritha, Huntemann, Marcel, Clum, Alicia, Pillay, Manoj, Palaniappan, Krishnaveni, Varghese, Neha, Mikhailova, Natalia, Stamatis, Dimitrios, Reddy, T B K, Daum, Chris, Shapiro, Nicole, Markowitz, Victor, Ivanova, Natalia, Kyrpides, Nikos, Woyke, Tanja, Blom, Jochen, Whitman, William B, Venter, Stephanus N, Steenkamp, Emma T

“…[This corrects the article on p. 1154 in vol. 8, PMID: 28694797.]…”
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Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial by Kim, Sung-Bae, Dent, Rebecca, Im, Seock-Ah, Espié, Marc, Blau, Sibel, Tan, Antoinette R, Isakoff, Steven J, Oliveira, Mafalda, Saura, Cristina, Wongchenko, Matthew J, Kapp, Amy V, Chan, Wai Y, Singel, Stina M, Maslyar, Daniel J, Baselga, José, Kim, Sung-Bae, Lee, Keun Seok, Im, Seock-Ah, Espié, Marc, Wang, Hwei-Chung, Blau, Sibel, Dent, Rebecca, Tan, Antoinette, Sohn, Joo Hyuk, De Laurentiis, Michelino, Estevez, Laura Garcia, Huang, Chiun-Sheng, Romieu, Gilles, Velez, Michel, Villanueva, Rafael, Conte, Pier Franco, Dakhil, Shaker, Debled, Marc, Martin, Antonio Gonzalez, Hurvitz, Sara, Kim, Jee Hyun, Levy, Christelle, Oliveira, Mafalda, Rovira, Pedro Sanchez, Seo, Jae Hong, Valero, Vicente, Vidal, Gregory, Wong, Andrea, Allison, Mary Ann K, Figlin, Robert, Chan, David, Chen, Shin-Cheh, Chen, Yen-Hsun, Cobleigh, Melody, De Braud, Filippo, Dirix, Luc, Hansen, Vincent, Bessard, Anne Hardy, Iannotti, Nicholas, Isakoff, Steven, Lawler, William, Montaño, Alvaro, Salkini, Mohamad, Seigel, Leonard

“…The oral AKT inhibitor ipatasertib is being investigated in cancers with a high prevalence of PI3K/AKT pathway activation, including triple-negative breast…”
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A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors by Saura, Cristina, Roda, Desamparados, Roselló, Susana, Oliveira, Mafalda, Macarulla, Teresa, Pérez-Fidalgo, José Alejandro, Morales-Barrera, Rafael, Sanchis-García, Juan Manuel, Musib, Luna, Budha, Nageshwar, Zhu, Jin, Nannini, Michelle, Chan, Wai Y, Sanabria Bohórquez, Sandra M, Meng, Raymond D, Lin, Kui, Yan, Yibing, Patel, Premal, Baselga, José, Tabernero, Josep, Cervantes, Andrés

“…Activation of AKT signaling by PTEN loss or PIK3CA mutations occurs frequently in human cancers, but targeting AKT has been difficult due to the…”
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SeqCode facilitates naming of South African rhizobia left in limbo by van Lill, Melandré, Venter, Stephanus N., Muema, Esther K., Palmer, Marike, Chan, Wai Y., Beukes, Chrizelle W., Steenkamp, Emma T.

“…South Africa is well-known for the diversity of its legumes and their nitrogen-fixing bacterial symbionts. However, in contrast to their plant partners,…”
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Genome-informed Bradyrhizobium taxonomy: where to from here? by Avontuur, Juanita R., Palmer, Marike, Beukes, Chrizelle W., Chan, Wai Y., Coetzee, Martin P.A., Blom, Jochen, Stępkowski, Tomasz, Kyrpides, Nikos C., Woyke, Tanja, Shapiro, Nicole, Whitman, William B., Venter, Stephanus N., Steenkamp, Emma T.

“…Bradyrhizobium is thought to be the largest and most diverse rhizobial genus, but this is not reflected in the number of described species. Although it was one…”
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Bradyrhizobium xenonodulans sp. nov. isolated from nodules of Australian Acacia species invasive to South Africa by Claassens, Ricu, Venter, Stephanus N., Beukes, Chrizelle W., Stępkowski, Tomasz, Chan, Wai Y., Steenkamp, Emma T.

“…A genealogical concordance approach was used to delineate strains isolated from Acacia dealbata and Acacia mearnsii root nodules in South Africa. These…”
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Zanubrutinib Versus Ibrutinib in Symptomatic Waldenström Macroglobulinemia: Final Analysis From the Randomized Phase III ASPEN Study by Dimopoulos, Meletios A, Opat, Stephen, D'Sa, Shirley, Jurczak, Wojciech, Lee, Hui-Peng, Cull, Gavin, Owen, Roger G, Marlton, Paula, Wahlin, Björn E, Garcia-Sanz, Ramon, McCarthy, Helen, Mulligan, Stephen, Tedeschi, Alessandra, Castillo, Jorge J, Czyz, Jaroslaw, Fernández de Larrea, Carlos, Belada, David, Libby, Edward, Matous, Jeffrey, Motta, Marina, Siddiqi, Tanya, Tani, Monica, Trněný, Marek, Minnema, Monique C, Buske, Christian, Leblond, Veronique, Treon, Steven P, Trotman, Judith, Chan, Wai Y, Schneider, Jingjing, Allewelt, Heather, Patel, Sheel, Cohen, Aileen, Tam, Constantine S

“…The phase III ASPEN study demonstrated the comparable efficacy and improved safety of zanubrutinib versus ibrutinib in patients with Waldenström…”
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Pooled safety analysis of zanubrutinib monotherapy in patients with B-cell malignancies by Tam, Constantine S., Dimopoulos, Meletios, Garcia-Sanz, Ramon, Trotman, Judith, Opat, Stephen, Roberts, Andrew W., Owen, Roger, Song, Yuqin, Xu, Wei, Zhu, Jun, Li, Jianyong, Qiu, Lugui, D'Sa, Shirley, Jurczak, Wojciech, Cull, Gavin, Marlton, Paula, Gottlieb, David, Munoz, Javier, Phillips, Tycel, Du, Chenmu, Ji, Meng, Zhou, Lei, Guo, Haiyi, Zhu, Hongjie, Chan, Wai Y., Cohen, Aileen, Novotny, William, Huang, Jane, Tedeschi, Alessandra

“…Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor evaluated in multiple B-cell malignancy studies. We constructed a pooled safety analysis to…”
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Paraburkholderia youngii sp. nov. and ‘Paraburkholderia atlantica’ – Brazilian and Mexican Mimosa-associated rhizobia that were previously known as Paraburkholderia tuberum sv. mimosae by Mavima, Lazarus, Beukes, Chrizelle W., Palmer, Marike, De Meyer, Sofie E., James, Euan K., Maluk, Marta, Gross, Eduardo, dos Reis Junior, Fabio Bueno, Avontuur, Juanita R., Chan, Wai Y., Venter, Stephanus N., Steenkamp, Emma T.

“…Previous studies have recognized South and Central/Latin American mimosoid legumes in the genera Mimosa, Piptadenia and Calliandra as hosts for various…”
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Zanubrutinib for the treatment of MYD88 wild-type Waldenström macroglobulinemia: a substudy of the phase 3 ASPEN trial by Dimopoulos, Meletios, Sanz, Ramon Garcia, Lee, Hui-Peng, Trneny, Marek, Varettoni, Marzia, Opat, Stephen, D'Sa, Shirley, Owen, Roger G., Cull, Gavin, Mulligan, Stephen, Czyz, Jaroslaw, Castillo, Jorge J., Motta, Marina, Siddiqi, Tanya, Gironella Mesa, Mercedes, Granell Gorrochategui, Miquel, Talaulikar, Dipti, Zinzani, Pier Luigi, Askari, Elham, Grosicki, Sebastian, Oriol, Albert, Rule, Simon, Kloczko, Janusz, Tedeschi, Alessandra, Buske, Christian, Leblond, Veronique, Trotman, Judith, Chan, Wai Y., Michel, Jan, Schneider, Jingjing, Tan, Ziwen, Cohen, Aileen, Huang, Jane, Tam, Constantine S.

“…Patients with Waldenström macroglobulinemia (WM) lacking activating mutations in the MYD88 gene (MYD88WT) have demonstrated relatively poor outcomes to…”
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Overall survival (OS) update of the double-blind placebo (PBO)-controlled randomized phase 2 LOTUS trial of first-line ipatasertib (IPAT) + paclitaxel (PAC) for locally advanced/metastatic triple-negative breast cancer (mTNBC) by Dent, Rebecca, Im, Seock-Ah, Espie, Marc, Blau, Sibel, Tan, Antoinette R., Isakoff, Steven J., Oliveira, Mafalda, Saura, Cristina, Wongchenko, Matthew, Kapp, Amy V., Chan, Wai Y., Singel, Stina M., Maslyar, Daniel J., Baselga, Jose, Kim, Sung-Bae

“…Abstract only…”
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pulmonary complications of COVID-19 : a case report by Chan, Wai Y., Rahmat, Kartini, Hamid, Marlina T. Ramli, Lim, Yi T., Ng, Ching C., Gowdh, Nadia F. M.

“…Rapid evolution of pulmonary complications associated with severe COVID-19 pneumonia often pose a management challenge to clinicians especially in the critical…”
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Bradyrhizobium altum sp. nov., Bradyrhizobium oropedii sp. nov. and Bradyrhizobium acaciae sp. nov. from South Africa show locally restricted and pantropical nodA phylogeographic patterns by Avontuur, Juanita R., Palmer, Marike, Beukes, Chrizelle W., Chan, Wai Y., Tasiya, Taponeswa, van Zyl, Elritha, Coetzee, Martin P.A., Stepkowski, Tomasz, Venter, Stephanus N., Steenkamp, Emma T.

“…[Display omitted] •Bradyrhizobium species isolated from diverse legumes in South Africa.•Delineation of these species following the genealogical concordance…”
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Biomarker analysis of the ASPEN study comparing zanubrutinib with ibrutinib for patients with Waldenström macroglobulinemia by Tam, Constantine S., Opat, Stephen, D'Sa, Shirley, Jurczak, Wojciech, Lee, Hui-Peng, Cull, Gavin, Owen, Roger G., Marlton, Paula, Wahlin, Björn E., García-Sanz, Ramón, McCarthy, Helen, Mulligan, Stephen, Tedeschi, Alessandra, Castillo, Jorge J., Czyż, Jarosław, Fernández De Larrea, Carlos, Belada, David, Libby, Edward, Matous, Jeffrey, Motta, Marina, Siddiqi, Tanya, Tani, Monica, Trněný, Marek, Minnema, Monique C., Buske, Christian, Leblond, Véronique, Treon, Steven P., Trotman, Judith, Wu, Binghao, Yu, Yiling, Shen, Zhirong, Chan, Wai Y., Schneider, Jingjing, Allewelt, Heather, Cohen, Aileen, Dimopoulos, Meletios A.

“…•Patients with Waldenström macroglobulinemia and mutations in CXCR4 or TP53 had poorer prognosis after treatment with BTKis.•Patients with CXCR4 or TP53…”
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