Search Results - "Chan, W C W"

Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors by Dai, Qin, Wilhelm, Stefan, Ding, Ding, Syed, Abdullah Muhammad, Sindhwani, Shrey, Zhang, Yuwei, Chen, Yih Yang, MacMillan, Presley, Chan, Warren C. W

“…Coating the nanoparticle surface with cancer cell recognizing ligands is expected to facilitate specific delivery of nanoparticles to diseased cells in vivo…”
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Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver Nanoparticles by Walkey, Carl D, Olsen, Jonathan B, Song, Fayi, Liu, Rong, Guo, Hongbo, Olsen, D. Wesley H, Cohen, Yoram, Emili, Andrew, Chan, Warren C. W

“…Using quantitative models to predict the biological interactions of nanoparticles will accelerate the translation of nanotechnology. Here, we characterized the…”
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Quantum Dots in Biological and Biomedical Research: Recent Progress and Present Challenges by Klostranec, J. M., Chan, W. C. W.

“…The marriage of nanomaterials with biology has produced a new generation of technologies that can profoundly impact biological and biomedical research. Quantum…”
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Synthesis and Surface Modification of Highly Monodispersed, Spherical Gold Nanoparticles of 50−200 nm by Perrault, Steven D, Chan, Warren C. W

“…Elucidating the impact of nanoparticle size and shape on biological systems is of fundamental importance to nanotoxicology and biomedicine. Currently, the…”
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Polyethylene Glycol Backfilling Mitigates the Negative Impact of the Protein Corona on Nanoparticle Cell Targeting by Dai, Qin, Walkey, Carl, Chan, Warren C. W.

“…In protein‐rich environments such as the blood, the formation of a protein corona on receptor‐targeting nanoparticles prevents target recognition. As a result,…”
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Are Quantum Dots Toxic? Exploring the Discrepancy Between Cell Culture and Animal Studies by Tsoi, Kim M, Dai, Qin, Alman, Benjamin A, Chan, Warren C. W

“…Despite significant interest in developing quantum dots (QDs) for biomedical applications, many researchers are convinced that QDs will never be used for…”
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Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake by Walkey, Carl D, Olsen, Jonathan B, Guo, Hongbo, Emili, Andrew, Chan, Warren C. W

“…Delivery and toxicity are critical issues facing nanomedicine research. Currently, there is limited understanding and connection between the physicochemical…”
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Strategies for the intracellular delivery of nanoparticles by Chou, Leo Y T, Ming, Kevin, Chan, Warren C W

“…The ability to target contrast agents and therapeutics inside cells is becoming important as we strive to decipher the complex network of events that occur…”
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An Analysis of the Binding Function and Structural Organization of the Protein Corona by Zhang, Yuwei, Wu, Jamie L. Y, Lazarovits, James, Chan, Warren C. W

“…Blood proteins adsorb onto the surface of nanoparticles after intravenous injection to form a protein corona. The underlying organization and binding function…”
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A Plasmonic DNAzyme Strategy for Point-of-Care Genetic Detection of Infectious Pathogens by Zagorovsky, Kyryl, Chan, Warren C. W.

“…Always use detection: Signal amplification from DNAzymes (see scheme) was combined with gold nanoparticles (GNPs) to give a simple and sensitive colorimetric…”
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Secreted Biomolecules Alter the Biological Identity and Cellular Interactions of Nanoparticles by Albanese, Alexandre, Walkey, Carl D, Olsen, Jonathan B, Guo, Hongbo, Emili, Andrew, Chan, Warren C. W

“…A nanoparticle’s physical and chemical properties at the time of cell contact will determine the ensuing cellular response. Aggregation and the formation of a…”
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Segmentation and genome annotation algorithms for identifying chromatin state and other genomic patterns by Libbrecht, Maxwell W, Chan, Rachel C W, Hoffman, Michael M

“…Segmentation and genome annotation (SAGA) algorithms are widely used to understand genome activity and gene regulation. These algorithms take as input…”
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The Role of Nanoparticle Design in Determining Analytical Performance of Lateral Flow Immunoassays by Zhan, Li, Guo, Shuang-zhuang, Song, Fayi, Gong, Yan, Xu, Feng, Boulware, David R, McAlpine, Michael C, Chan, Warren C. W, Bischof, John C

“…Rapid, simple, and cost-effective diagnostics are needed to improve healthcare at the point of care (POC). However, the most widely used POC diagnostic, the…”
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DNA assembly of nanoparticle superstructures for controlled biological delivery and elimination by Chou, Leo Y. T., Zagorovsky, Kyryl, Chan, Warren C. W.

“…The assembly of nanomaterials using DNA can produce complex nanostructures, but the biological applications of these structures remain unexplored. Here, we…”
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Elucidating the Mechanism of Cellular Uptake and Removal of Protein-Coated Gold Nanoparticles of Different Sizes and Shapes by Chithrani, B. Devika, Chan, Warren C. W.

“…We investigated the mechanism by which transferrin-coated gold nanoparticles (Au NP) of different sizes and shapes entered mammalian cells. We determined that…”
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Improving nanoparticle diffusion through tumor collagen matrix by photo-thermal gold nanorods by Raeesi, Vahid, Chan, Warren C W

“…Collagen (I) impairs the targeting of nanoparticles to tumor cells by obstructing their diffusion inside dense tumor interstitial matrix. This potentially…”
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Nanoparticle-mediated cellular response is size-dependent by Chan, Warren C. W, Jiang, Wen, Kim, Betty Y. S, Rutka, James T

“…Nanostructures of different sizes, shapes and material properties have many applications in biomedical imaging, clinical diagnostics and therapeutics 1 , 2 , 3…”
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Nanotoxicity: the growing need for in vivo study by Fischer, Hans C, Chan, Warren CW

“…Nanotoxicology is emerging as an important subdiscipline of nanotechnology. Nanotoxicology refers to the study of the interactions of nanostructures with…”
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Mediating Tumor Targeting Efficiency of Nanoparticles Through Design by Perrault, Steven D, Walkey, Carl, Jennings, Travis, Fischer, Hans C, Chan, Warren C. W

“…Here we systematically examined the effect of nanoparticle size (10−100 nm) and surface chemistry (i.e., poly(ethylene glycol)) on passive targeting of tumors…”
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Tailoring nanoparticle designs to target cancer based on tumor pathophysiology by Sykes, Edward A., Dai, Qin, Sarsons, Christopher D., Chen, Juan, Rocheleau, Jonathan V., Hwang, David M., Zheng, Gang, Cramb, David T., Rinker, Kristina D., Chan, Warren C. W.

“…Nanoparticles can provide significant improvements in the diagnosis and treatment of cancer. How nanoparticle size, shape, and surface chemistry can affect…”
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