Search Results - "Chan, Vera S F"

DC-SIGN and L-SIGN: the SIGNs for infection by Khoo, Ui-Soon, Chan, Kelvin Y. K., Chan, Vera S. F., Lin, C. L. Steve

“…Two closely related trans -membrane C-type lectins dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin (DC-SIGN or CD209 )…”
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Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells by Chen, Yongxiong, Hwang, Shiuh-Lin, Chan, Vera S F, Chung, Nancy P Y, Wang, Shu-Rong, Li, Zhongye, Ma, Jing, Lin, Chia-Wei, Hsieh, Ya-Ju, Chang, Kao-Ping, Kung, Sui-Sum, Wu, Yi-Chia, Chu, Cheng-Wei, Tai, Hsiao-Ting, Gao, George F, Zheng, Bojian, Yokoyama, Kazunari K, Austyn, Jonathan M, Lin, Chen-Lung S

“…During disease progression to AIDS, HIV-1 infected individuals become increasingly immunosuppressed and susceptible to opportunistic infections. It has also…”
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Heterosubtypic Protection Induced by a Live Attenuated Influenza Virus Vaccine Expressing Galactose-α-1,3-Galactose Epitopes in Infected Cells by Yan, Li-Meng, Lau, Sylvia P N, Poh, Chek Meng, Chan, Vera S F, Chan, Michael C W, Peiris, Malik, Poon, Leo L M

“…Anti-galactose-α-1,3-galactose (anti-α-Gal) antibody is naturally expressed at a high level in humans. It constitutes about 1% of immunoglobulins found in…”
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Systemic Lupus Erythematosus Patients Exhibit Reduced Expression of CLEC16A Isoforms in Peripheral Leukocytes by Tam, Rachel C Y, Lee, Alfred L H, Yang, Wanling, Lau, Chak Sing, Chan, Vera S F

“…Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with multiple etiological factors. The SLE susceptibility locus on chromosome 16p13…”
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Toll prevents a move by Chan, Vera SF, Tsao, Sai Wah, Lin, Chen-Lung S

“…Commentary to: TLR3 activation inhibits nasopharyngeal carcinoma metastasis via down-regulation of chemokine receptor CXCR4 Yu Zhang, Ruili Sun, Bei Liu,…”
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Recapitulating primary immunodeficiencies with expanded potential stem cells: Proof of concept with STAT1 gain of function by Liu, Xueyan, Chan, Vera S.F., Smith, Kenneth G.C., Ming, Chang, Or, Chung Sze, Tsui, Faria T.W., Gao, Bo, Cook, Matthew C., Liu, Pentao, Lau, Chak Sing, Li, Philip Hei

“…[Display omitted] Inborn errors of immunity (IEI) often lack specific disease models and personalized management. Signal transducer and activator of…”
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Role of ICOS versus CD28 in antiviral immunity by Bertram, Edward M., Tafuri, Anna, Shahinian, Arda, Chan, Vera S. F., Hunziker, Lukas, Recher, Mike, Ohashi, Pamela S., Mak, Tak W., Watts, Tania H.

“…The costimulatory protein ICOS is inducibly expressed on activated T cells. Previous results have shown that ICOS–/– mice are defective in germinal center…”
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Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome by Chan, Kelvin Y. K., Ching, Johannes C. Y., Xu, M. S., Cheung, Annie N. Y., Yip, Shea-Ping, Yam, Loretta Y. C., Lai, Sik-To, Chu, Chung-Ming, Wong, Andrew T. Y., Song, You-Qiang, Huang, Fang-Ping, Liu, Wei, Chung, P. H., Leung, G. M., Chow, Eudora Y. D., Chan, Eric Y. T., Chan, Jane C. K., Ngan, Hextan, Tam, Paul, Chan, Li-Chong, Sham, Pak, Chan, Vera S. F., Peiris, Malik, Lin, Steve C. L., Khoo, Ui-Soon

“…Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T…”
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Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes by Chan, Vera S. F., Chau, Suk-yi, Tian, Lina, Chen, Yan, Kwong, Simon K. Y., Quackenbush, John, Dallman, Margaret, Lamb, Jonathan, Tam, Paul K. H.

“…Sonic hedgehog (Shh) is a crucial morphogen in the development of numerous tissues and organs, including the nervous system, gastrointestinal tract and lung…”
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ICOS is essential for effective T-helper-cell responses by Mak, Tak W, Tafuri, Anna, Shahinian, Arda, Bladt, Friedhelm, Yoshinaga, Steve K, Jordana, Manel, Wakeham, Andrew, Boucher, Louis-Martin, Bouchard, Denis, Chan, Vera S. F, Duncan, Gordon, Odermatt, Bernhard, Ho, Alexandra, Itie, Annick, Horan, Tom, Whoriskey, John S, Pawson, Tony, Penninger, Josef M, Ohashi, Pamela S

“…The outcome of T-cell responses after T-cell encounter with specific antigens is modulated by co-stimulatory signals, which are required for both lymphocyte…”
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Homozygous L-SIGN ( CLEC4M ) plays a protective role in SARS coronavirus infection by Khoo, Ui-Soon, Lin, Chen-Lung S, Chan, Vera S F, Chan, Kelvin Y K, Chen, Yongxiong, Poon, Leo L M, Cheung, Annie N Y, Zheng, Bojian, Chan, Kwok-Hung, Mak, William, Ngan, Hextan Y S, Xu, Xiaoning, Screaton, Gavin, Tam, Paul K H, Austyn, Jonathan M, Chan, Li-Chong, Yip, Shea-Ping, Peiris, Malik

“…Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as…”
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Chondrocyte antigen expression, immune response and susceptibility to arthritis by Chan, Vera S. F., Cohen, E. Suzanne, Weissensteiner, Thomas, Cheah, Kathryn S. E., Bodmer, Helen C.

“…The association of HLA-B27 with certain forms of arthritis implies a role for MHC class I-restricted T cells in the arthritic process. Our aim was to study…”
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Mammary gland-specific secretion of biologically active immunosuppressive agent cytotoxic-T-lymphocyte antigen 4 human immunoglobulin fusion protein (CTLA4Ig) in milk by transgenesis by Lui, Vincent C.H, Tam, Paul K.H, Leung, Michael Y.K, Lau, James Y.B, Chan, Jacqueline K.Y, Chan, Vera S.F, Dallman, Margaret, Cheah, Kathryn S.E

“…A major challenge in the field of transplantation is to prevent graft rejection and prolong graft survival. Tolerance induction is a promising way to achieve…”
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Subtle Effects on Myelin Basic Protein-Specific T Cell Responses Can Lead to a Major Reduction in Disease Susceptibility in Experimental Allergic Encephalomyelitis by Vowles, Cheryl, Chan, Vera S. F, Bodmer, Helen C

“…The presence of potentially autoreactive T cells is a necessary, but not sufficient, condition for the development of autoimmune disease. However, the…”
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MicroRNA-mediated modulations in hyperactive plasmacytoid dendritic cells in systemic lupus erythematosus (P4072) by Yan, Sheng, Tam, Rachel CY, Chan, Vera SF, Lau, Chak Sing

“…Abstract Systemic lupus erythematosus (SLE) patients are typically presented by their increased serum type I interferon (IFN) activities. Plasmacytoid…”
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CLEC16A: A novel C-type lectin domain-containing protein pertaining to systemic lupus erythematosus (P4092) by Tam, Rachel CY, Yan, Sheng, Lau, Chak Sing, Chan, Vera SF

“…Abstract Several independent genome wide association studies have shown associations of single nucleotide polymorphisms within the C-type lectin domain family…”
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Reply to "Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection" by Chan, Kelvin Y K, Chan, Vera S F, Chen, Yongxiong, Yip, Shea-Ping, Lin, Chen-Lung S, Khoo, Ui-Soon

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Calcineurin Aα plays an exclusive role in TCR signaling in mature but not in immature T cells by Chan, Vera S. F., Wong, Camilla, Ohashi, Pamela S.

“…Calcineurin has been demonstrated as one of the key enzymes in TCR‐mediated signaling cascades that lead to the transcription of a variety of cytokines…”
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Calcineurin Aalpha plays an exclusive role in TCR signaling in mature but not in immature T cells by Chan, Vera S F, Wong, Camilla, Ohashi, Pamela S

“…Calcineurin has been demonstrated as one of the key enzymes in TCR-mediated signaling cascades that lead to the transcription of a variety of cytokines…”
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Dendritic cells: sentinels against pathogens by Chung, N P-Y, Chen, Y, Chan, Vera S F, Tam, P K H, Lin, C-L S

“…Dendritic cells (DCs) are the most potent antigen-presenting cells, and are regarded as "natural adjuvants" for the induction of primary T or T-dependent…”
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