Search Results - "Chan, Tom S."

Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac by Chan, Tom S, Yu, Hongbin, Moore, Amanda, Khetani, Salman R, Kehtani, Salman R, Tweedie, Donald

“…Generating accurate in vitro intrinsic clearance data is an important aspect of predicting in vivo human clearance. Primary hepatocytes in suspension are…”
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Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia by Chan, Tom S, Cassim, Shamir, Raymond, Valérie-Ann, Gottschalk, Sven, Merlen, Grégory, Zwingmann, Claudia, Lapierre, Pascal, Darby, Peter, Mazer, Cyril David, Bilodeau, Marc

“…The liver is a highly vascularized organ receiving a dual input of oxygenated blood from the hepatic artery and portal vein. The impact of decreased blood flow…”
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Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions by Ramsden, Diane, Tweedie, Donald J, Chan, Tom S, Tracy, Timothy S

“…Cytochrome P450 (P450) protein-protein interactions resulting in modulation of enzyme activities have been well documented using recombinant isoforms. This…”
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A novel system to determine activity of individual uridine 5′-diphospho-glucuronosyltransferase (UGT) isoforms: Recombinant UGT-beads by Wang, Ting, Taub, Mitchell E., Chan, Tom S.

“…Previous work demonstrated that human liver microsomes (HLMs) can spontaneously bind to silica-coated magnetizable beads (HLM-beads) and that these HLM-beads…”
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HLM-beads: Rapid Assessment of Nonspecific Binding to Human Liver Microsomes Using Magnetizable Beads by Wang, Ting, Whitcher-Johnstone, Andrea, Keith-Luzzi, Monica, Chan, Tom S

“…In early drug development, drug-drug interaction risk is routinely assessed using human liver microsomes (HLMs). Nonspecific binding of drugs to HLMs can…”
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Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac by Chan, Tom S, Yu, Hongbin, Moore, Amanda, Khetani, Salman R, Tweedie, Donald

“…Generating accurate in vitro intrinsic clearance data is an important aspect of predicting in vivo human clearance. Primary hepatocytes in suspension are…”
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Evaluation of Erythromycin as a Tool to Assess CYP3A Contribution of Low Clearance Compounds in a Long-Term Hepatocyte Culture by Chan, Tom S., Scaringella, Young-Sun, Raymond, Klairynne, Taub, Mitchell E.

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Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes by Siraki, Arno G, Pourahmad, Jalal, Chan, Tom S, Khan, Sumsullah, O’Brien, Peter J

“…The rat hepatocyte catalyzed oxidation of 2′,7′-dichlorofluorescin to form the fluorescent 2,7′-dichlorofluorescein was used to measure endogenous and…”
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Human Liver Microsomes Immobilized on Magnetizable Beads: A Novel Approach to Study In Vitro Drug Metabolism by Horspool, Alexander M, Wang, Ting, Scaringella, Young-Sun, Taub, Mitchell E, Chan, Tom S

“…Human liver microsomes (HLM) are a commonly used tool to study drug metabolism in vitro. Typical experiments conducted using suspensions of HLM can be…”
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Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac by Ramsden, Diane, Tweedie, Donald J, Chan, Tom S, Taub, Mitchell E, Li, Yongmei

“…An increased appreciation of the importance of transporter and enzyme interplay in drug clearance and a desire to delineate these mechanisms necessitates the…”
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Characterization of Divergent Metabolic Pathways in Elucidating an Unexpected, Slow-Forming, and Long Half-Life Major Metabolite of Iclepertin by Chan, Tom S., Byer-Alcorace, Alexander J., Latli, Bachir, Liu, Pingrong, Maw, Hlaing H., Raymond, Klairynne G., Scaringella, Young-Sun, Teitelbaum, Aaron M., Wang, Ting, Whitcher-Johnstone, Andrea, Taub, Mitchell E.

“…Purpose After single oral dosing of the glycine reuptake transporter (GlyT1) inhibitor, iclepertin (BI 425809), a single major circulating metabolite, M530a,…”
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The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [14C]-BI 425809 in Healthy Males by Burkard, Ute, Desch, Michael, Shatillo, Yury, Wunderlich, Glen, Mack, Salome Rebecca, Schlecker, Christina, Teitelbaum, Aaron M., Liu, Pingrong, Chan, Tom S.

“…Background and Objectives BI 425809, a novel glycine transporter-1 inhibitor, may ameliorate cognitive deficits in schizophrenia. The objectives of the studies…”
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Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase 1(NQO1) by Chan, Tom S, Teng, Shirley, Wilson, John X, Galati, Giuseppe, Khan, Sumsallah, O'Brien, Peter J

“…The commonest mitochondrial diseases are probably those impairing the function of complex I of the respiratory electron transport chain. Such complex I…”
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Correction to: The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [14C]‑BI 425809 in Healthy Males by Burkard, Ute, Desch, Michael, Shatillo, Yury, Wunderlich, Glen, Mack, Salome Rebecca, Schlecker, Christina, Teitelbaum, Aaron M., Liu, Pingrong, Chan, Tom S.

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Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor by Desch, Michael, Wunderlich, Glen, Goettel, Markus, Goetz, Sophia, Liesenfeld, Karl-Heinz, Chan, Tom S., Rosenbrock, Holger, Sennewald, Regina, Link, Jasmin, Keller, Sascha, Wind, Sven

“…Background and Objective Increased glycine availability at the synaptic cleft may enhance N -methyl-D-aspartate receptor signalling and provide a promising…”
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The impact of a CYP2C8-CYP3A4 protein–protein interaction on time dependent inhibition of CYP2C8 by Whitcher-Johnstone, Andrea, Chan, Tom S.

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The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress by Chan, Tom S., Shangari, Nandita, Wilson, John X., Chan, Helen, Butterworth, Roger F., O'Brien, Peter J.

“…Most animals synthesize ascorbate. It is an essential enzymatic cofactor for the synthesis of a variety of biological molecules and also a powerful…”
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Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development by Tomlinson, Lindsay, Ramsden, Diane, Leite, Sofia Batista, Beken, Sonja, Bonzo, Jessica A., Brown, Paul, Candarlioglu, Pelin L., Chan, Tom S., Chen, Eugene, Choi, Colin K., David, Rhiannon, Delrue, Nathalie, Devine, Patrick J., Ford, Kevin, Garcia, Martha Iveth, Gosset, James R., Hewitt, Philip, Homan, Kimberly, Irrechukwu, Onyi, Kopec, Anna K., Liras, Jennifer L., Mandlekar, Sandhya, Raczynski, Arek, Sadrieh, Nakissa, Sakatis, Melanie Z., Siegel, Jeffrey, Sung, Kyung, Sunyovszki, Ilona, Van Vleet, Terry R., Ekert, Jason E., Hardwick, Rhiannon N.

“…In May 2022, there is an International Regulatory and Pharmaceutical Industry (Innovation and Quality [IQ] Microphysiological Systems [MPS] Affiliate) Workshop…”
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Glycogenolysis is directed towards ascorbate synthesis by glutathione conjugation by Chan, Tom S, Wilson, John X, O’Brien, Peter J

“…Using isolated rat hepatocytes we have shown that glutathione (GSH) depletion by glutathione- S-transferase (GST)-catalyzed conjugation with 1-bromoheptane or…”
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Flavonoid B-Ring Chemistry and Antioxidant Activity: Fast Reaction Kinetics by Sekher Pannala, Ananth, Chan, Tom S., O'Brien, Peter J., Rice-Evans, Catherine A.

“…Rapid scavenging of the model stable radical cation, ABTS•+, has been applied to screen for the antioxidant activity of flavonoids. The reaction follows two…”
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