Search Results - "Chan, Rebecca W. Y"

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments by Sun, Kun, Jiang, Peiyong, Chan, K. C. Allen, Wong, John, Cheng, Yvonne K. Y., Liang, Raymond H. S., Chan, Wai-kong, Ma, Edmond S. K., Chan, Stephen L., Cheng, Suk Hang, Chan, Rebecca W. Y., Tong, Yu K., Ng, Simon S. M., Wong, Raymond S. M., Hui, David S. C., Leung, Tse Ngong, Leung, Tak Y., Lai, Paul B. S., Chiu, Rossa W. K., Lo, Yuk Ming Dennis

“…Plasma consists of DNA released from multiple tissues within the body. Using genome-wide bisulfite sequencing of plasma DNA and deconvolution of the sequencing…”
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High-resolution analysis for urinary DNA jagged ends by Xie, Tingting, Wang, Guangya, Ding, Spencer C., Lee, Wing-Shan, Cheng, Suk Hang, Chan, Rebecca W. Y., Zhou, Ze, Ma, Mary-Jane L., Han, Diana S. C., Teoh, Jeremy Y. C., Lam, W. K. Jacky, Jiang, Peiyong, Chiu, Rossa W. K., Chan, K. C. Allen, Lo, Y. M. Dennis

“…Single-stranded ends of double-stranded DNA (jagged ends) are more abundant in urinary DNA than in plasma DNA. However, the lengths of jagged ends in urinary…”
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Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing by Chan, Rebecca W Y, Jiang, Peiyong, Peng, Xianlu, Tam, Lai-Shan, Liao, Gary J W, Li, Edmund K M, Wong, Priscilla C H, Sun, Hao, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…We performed a high-resolution analysis of the biological characteristics of plasma DNA in systemic lupus erythematosus (SLE) patients using massively parallel…”
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Detection and characterization of jagged ends of double-stranded DNA in plasma by Jiang, Peiyong, Xie, Tingting, Ding, Spencer C, Zhou, Ze, Cheng, Suk Hang, Chan, Rebecca W Y, Lee, Wing-Shan, Peng, Wenlei, Wong, John, Wong, Vincent W S, Chan, Henry L Y, Chan, Stephen L, Poon, Liona C Y, Leung, Tak Y, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…Cell-free DNA in plasma has been used for noninvasive prenatal testing and cancer liquid biopsy. The physical properties of cell-free DNA fragments in plasma,…”
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DNA of Erythroid Origin Is Present in Human Plasma and Informs the Types of Anemia by Lam, W K Jacky, Gai, Wanxia, Sun, Kun, Wong, Raymond S M, Chan, Rebecca W Y, Jiang, Peiyong, Chan, Natalie P H, Hui, Winnie W I, Chan, Anthony W H, Szeto, Cheuk-Chun, Ng, Siew C, Law, Man-Fai, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…There is much interest in the tissue of origin of circulating DNA in plasma. Data generated using DNA methylation markers have suggested that hematopoietic…”
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Genomic origin, fragmentomics, and transcriptional properties of long cell-free DNA molecules in human plasma by Che, Huiwen, Jiang, Peiyong, Choy, L Y Lois, Cheng, Suk Hang, Peng, Wenlei, Chan, Rebecca W Y, Liu, Jing, Zhou, Qing, Lam, W K Jacky, Yu, Stephanie C Y, Lau, So Ling, Leung, Tak Y, Wong, John, Wong, Vincent Wai-Sun, Wong, Grace L H, Chan, Stephen L, Chan, K C Allen, Lo, Y M Dennis

“…Recent studies have revealed an unexplored population of long cell-free DNA (cfDNA) molecules in human plasma using long-read sequencing technologies. However,…”
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Aberrant Concentrations of Liver-Derived Plasma Albumin mRNA in Liver Pathologies by Chan, Rebecca W.Y, Wong, John, Chan, Henry L.Y, Mok, Tony S.K, Lo, Wyatt Y.W, Lee, Vincent, To, Ka F, Lai, Paul B.S, Rainer, Timothy H, Lo, Y.M. Dennis, Chiu, Rossa W.K

“…We hypothesized that liver-derived mRNA, such as ALB (albumin) mRNA, would be released into human plasma with liver cell death. We genotyped ALB mRNA molecules…”
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Matrix metalloproteinase 9 mRNA: An early prognostic marker for patients with acute stroke by Graham, Colin A., Chan, Rebecca W.Y., Chan, Dexter Y.S., Chan, Cangel P.Y., Wong, Lawrence K.S., Rainer, Timothy H.

“…To investigate matrix metalloproteinase 9 (MMP9) mRNA as a prognostic marker in stroke. MMP9 mRNA concentrations in 126 stroke patients were analyzed using…”
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Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA by Serpas, Lee, Chan, Rebecca W. Y., Jiang, Peiyong, Ni, Meng, Sun, Kun, Rashidfarrokhi, Ali, Soni, Chetna, Sisirak, Vanja, Lee, Wing-Shan, Cheng, Suk Hang, Peng, Wenlei, Chan, K. C. Allen, Chiu, Rossa W. K., Reizis, Boris, Lo, Y. M. Dennis

“…Circulating DNA in plasma consists of short DNA fragments. The biological processes generating such fragments are not well understood. DNASE1L3 is a secreted…”
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The Biology of Cell-free DNA Fragmentation and the Roles of DNASE1, DNASE1L3, and DFFB by Han, Diana S.C., Ni, Meng, Chan, Rebecca W.Y., Chan, Vicken W.H., Lui, Kathy O., Chiu, Rossa W.K., Lo, Y.M. Dennis

“…Cell-free DNA (cf.DNA) is a powerful noninvasive biomarker for cancer and prenatal testing, and it circulates in plasma as short fragments. To elucidate the…”
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Epigenetic analysis of cell-free DNA by fragmentomic profiling by Zhou, Qing, Kang, Guannan, Jiang, Peiyong, Qiao, Rong, Lam, W. K. Jacky, Yu, Stephanie C. Y., Ma, Mary-Jane L., Ji, Lu, Cheng, Suk Hang, Gai, Wanxia, Peng, Wenlei, Shang, Huimin, Chan, Rebecca W. Y., Chan, Stephen L., Wong, Grace L. H., Hiraki, Linda T., Volpi, Stefano, Wong, Vincent W. S., Wong, John, Chiu, Rossa W. K., Chan, K. C. Allen, Lo, Y. M. Dennis

“…Cell-free DNA (cfDNA) fragmentation patterns contain important molecular information linked to tissues of origin. We explored the possibility of using…”
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Presence of Donor-Derived DNA and Cells in the Urine of Sex-Mismatched Hematopoietic Stem Cell Transplant Recipients: Implication for the Transrenal Hypothesis by Hung, Emily C.W, Shing, Tristan K.F, Chim, Stephen S.C, Yeung, Philip C, Chan, Rebecca W.Y, Chik, Ki W, Lee, Vincent, Tsui, Nancy B.Y, Li, Chi-Kong, Wong, Cesar S.C, Chiu, Rossa W.K, Lo, Y.M. Dennis

“…The term "transrenal DNA" was coined in 2000 to signify that DNA in urine may come from the passage of plasma DNA through the kidney barrier. Although DNA in…”
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Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction by Chan, Rebecca W.Y., Serpas, Lee, Ni, Meng, Volpi, Stefano, Hiraki, Linda T., Tam, Lai-Shan, Rashidfarrokhi, Ali, Wong, Priscilla C.H., Tam, Lydia H.P., Wang, Yueyang, Jiang, Peiyong, Cheng, Alice S.H., Peng, Wenlei, Han, Diana S.C., Tse, Patty P.P., Lau, Pik Ki, Lee, Wing-Shan, Magnasco, Alberto, Buti, Elisa, Sisirak, Vanja, AlMutairi, Nora, Chan, K.C. Allen, Chiu, Rossa W.K., Reizis, Boris, Lo, Y.M. Dennis

“…Plasma DNA fragmentomics is an emerging area in cell-free DNA diagnostics and research. In murine models, it has been shown that the extracellular DNase,…”
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Circulating leukocyte TBET and GATA3 mRNA in patients with acute coronary syndrome by Rainer, Timothy H, Chan, Rebecca W.Y, Graham, Colin A, Chan, Cangel P.Y, Tan, Patrick C.F, Yip, Gabriel W.K, Yu, Cheuk-Man

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Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs by Zhou, Ze, Ma, Mary-Jane L, Chan, Rebecca W Y, Lam, W K Jacky, Peng, Wenlei, Gai, Wanxia, Hu, Xi, Ding, Spencer C, Ji, Lu, Zhou, Qing, Cheung, Peter P H, Yu, Stephanie C Y, Teoh, Jeremy Y C, Szeto, Cheuk-Chun, Wong, John, Wong, Vincent W S, Wong, Grace L H, Chan, Stephen L, Hui, Edwin P, Ma, Brigette B Y, Chan, Anthony T C, Chiu, Rossa W K, Chan, K C Allen, Lo, Y M Dennis, Jiang, Peiyong

“…Cell-free DNA (cfDNA) fragmentation is nonrandom, at least partially mediated by various DNA nucleases, forming characteristic cfDNA end motifs. However, there…”
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Jagged Ends on Multinucleosomal Cell-Free DNA Serve as a Biomarker for Nuclease Activity and Systemic Lupus Erythematosus by Ding, Spencer C, Chan, Rebecca W Y, Peng, Wenlei, Huang, Liangbo, Zhou, Ze, Hu, Xi, Volpi, Stefano, Hiraki, Linda T, Vaglio, Augusto, Fenaroli, Paride, Bocca, Paola, Tam, Lai Shan, Wong, Priscilla C H, Tam, Lydia H P, Jiang, Peiyong, Chiu, Rossa W K, Allen Chan, K C, Dennis Lo, Y M

“…Abstract Background Jagged ends of plasma DNA are a recently recognized class of fragmentomic markers for cell-free DNA, reflecting the activity of nucleases…”
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Histone modifications of circulating nucleosomes are associated with changes in cell-free DNA fragmentation patterns by Bai, Jinyue, Jiang, Peiyong, Ji, Lu, Lam, W K Jacky, Zhou, Qing, Ma, Mary-Jane L, Ding, Spencer C, Ramakrishnan, Saravanan, Wan, Chun Wai, Yang, Tongxin Claire, Yukawa, Masashi, Chan, Rebecca W Y, Qiao, Rong, Yu, Stephanie C Y, Choy, L Y Lois, Shi, Yuwei, Wang, Zilong, Tam, Tommy H C, Law, Man Fai, Wong, Raymond S M, Wong, John, Chan, Stephen Lam, Wong, Grace L H, Wong, Vincent W S, Chan, K C Allen, Lo, Y M Dennis

“…The analysis of tissues of origin of cell-free DNA (cfDNA) is of research and diagnostic interest. Many studies focused on bisulfite treatment or…”
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Nuclease deficiencies alter plasma cell-free DNA methylation profiles by Han, Diana S C, Ni, Meng, Chan, Rebecca W Y, Wong, Danny K L, Hiraki, Linda T, Volpi, Stefano, Jiang, Peiyong, Lui, Kathy O, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…The effects of DNASE1L3 or DNASE1 deficiency on cell-free DNA (cfDNA) methylation were explored in plasma of mice deficient in these nucleases and in…”
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Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis by Wang, Guangya, Lam, W K Jacky, Ling, Lowell, Ma, Mary-Jane L, Ramakrishnan, Saravanan, Chan, Don C T, Lee, Wing-Shan, Cheng, Suk Hang, Chan, Rebecca W Y, Yu, Stephanie C Y, Tse, Irene O L, Wong, Wai Tat, Jiang, Peiyong, Chiu, Rossa W K, Allen Chan, K C, Lo, Y M Dennis

“…Nuclear-derived cell-free DNA (cfDNA) molecules in blood plasma are nonrandomly fragmented, bearing a wealth of information related to tissues of origin…”
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Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models by Chen, Meihui, Chan, Rebecca W. Y, Cheung, Peter P. H, Ni, Meng, Wong, Danny K. L, Zhou, Ze, Ma, Mary-Jane L, Huang, Liangbo, Xu, Xinzhou, Lee, Wing-Shan, Wang, Guangya, Lui, Kathy O, Lam, W. K. Jacky, Teoh, Jeremy Y. C, Ng, Chi-Fai, Jiang, Peiyong, Chan, K. C. Allen, Chiu, Rossa W. K, Lo, Y. M. Dennis

“…Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well…”
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