Search Results - "Chan, Pamela"

T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response by Carrera Silva, Eugenio A., Chan, Pamela Y., Joannas, Leonel, Errasti, Andrea E., Gagliani, Nicola, Bosurgi, Lidia, Jabbour, Maurice, Perry, Anthony, Smith-Chakmakova, Faye, Mucida, Daniel, Cheroutre, Hilde, Burstyn-Cohen, Tal, Leighton, Jonathan A., Lemke, Greg, Ghosh, Sourav, Rothlin, Carla V.

“…Dendritic cell (DC) activation is essential for the induction of immune defense against pathogens, yet needs to be tightly controlled to avoid chronic…”
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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model by Meilandt, William J, Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J, Stark, Kimberly L, Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A, Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David V

“…is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice…”
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Antibodies against the gH/gL/UL128/UL130/UL131 Complex Comprise the Majority of the Anti-Cytomegalovirus (Anti-CMV) Neutralizing Antibody Response in CMV Hyperimmune Globulin by FOUTS, Ashley E, CHAN, Pamela, STEPHAN, Jean-Philippe, VANDLEN, Richard, FEIERBACH, Becket

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation by Chae, Wook-Jin, Ehrlich, Allison K., Chan, Pamela Y., Teixeira, Alexandra M., Henegariu, Octavian, Hao, Liming, Shin, Jae Hun, Park, Jong-Hyun, Tang, Wai Ho, Kim, Sang-Taek, Maher, Stephen E., Goldsmith-Pestana, Karen, Shan, Peiying, Hwa, John, Lee, Patty J., Krause, Diane S., Rothlin, Carla V., McMahon-Pratt, Diane, Bothwell, Alfred L.M.

“…Exposure to a plethora of environmental challenges commonly triggers pathological type 2 cell-mediated inflammation. Here we report the pathological role of…”
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A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155 by Husain, Bushra, Ramani, Sree R., Chiang, Eugene, Lehoux, Isabelle, Paduchuri, Sairupa, Arena, Tia A., Patel, Ashka, Wilson, Blair, Chan, Pamela, Franke, Yvonne, Wong, Athena W., Lill, Jennie R., Turley, Shannon J., Gonzalez, Lino C., Grogan, Jane L., Martinez-Martin, Nadia

“…The Conditioned Media AlphaScreen represents a new platform for high throughput and sensitivity detection of interactions between plasma membrane proteins. The…”
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The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity by Chan, Pamela Y., Silva, Eugenio A. Carrera, De Kouchkovsky, Dimitri, Joannas, Leonel D., Hao, Liming, Hu, Donglei, Huntsman, Scott, Eng, Celeste, Licona-Limón, Paula, Weinstein, Jason S., Herbert, De'Broski R., Craft, Joseph E., Flavell, Richard A., Repetto, Silvia, Correale, Jorge, Burchard, Esteban G., Torgerson, Dara G., Ghosh, Sourav, Rothlin, Carla V.

“…Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also…”
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A strategy for risk mitigation of antibodies with fast clearance by Hötzel, Isidro, Theil, Frank-Peter, Bernstein, Lisa J., Prabhu, Saileta, Deng, Rong, Quintana, Leah, Lutman, Jeff, Sibia, Renuka, Chan, Pamela, Bumbaca, Daniela, Fielder, Paul, Carter, Paul J., Kelley, Robert F.

“…A majority of human therapeutic antibody candidates show pharmacokinetic properties suitable for clinical use, but an unexpectedly fast antibody clearance is…”
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Adapting an Electronic STI Risk Assessment Program for Use in Pediatric Primary Care by Ahmad, Fahd A., Chan, Pamela, McGovern, Collin, Dickey, Viani, Foraker, Randi, McKay, Virginia

“…Objectives: Sexually transmitted infections (STIs) are an ongoing public health issue in adolescents. the Centers for Disease Control and Prevention and…”
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A neutralizing anti-gH/gL monoclonal antibody is protective in the guinea pig model of congenital CMV infection by Auerbach, Marcy R, Yan, Donghong, Vij, Rajesh, Hongo, Jo-Anne, Nakamura, Gerald, Vernes, Jean-Michel, Meng, Y Gloria, Lein, Samantha, Chan, Pamela, Ross, Jed, Carano, Richard, Deng, Rong, Lewin-Koh, Nicholas, Xu, Min, Feierbach, Becket

“…Human cytomegalovirus (HCMV) is the most common cause of congenital virus infection. Congenital HCMV infection occurs in 0.2-1% of all births, and causes birth…”
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Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response by Dela Cruz Chuh, Josefa, Go, MaryAnn, Chen, Yvonne, Guo, Jun, Rafidi, Hanine, Mandikian, Danielle, Sun, Yonglian, Lin, Zhonghua, Schneider, Kellen, Zhang, Pamela, Vij, Rajesh, Sharpnack, Danielle, Chan, Pamela, de la Cruz, Cecile, Sadowsky, Jack, Seshasayee, Dhaya, Koerber, James T, Pillow, Thomas H, Phillips, Gail D, Rowntree, Rebecca K, Boswell, C Andrew, Kozak, Katherine R, Polson, Andrew G, Polakis, Paul, Yu, Shang-Fan, Dragovich, Peter S, Agard, Nicholas J

“…Early success with brentuximab vedotin in treating classical Hodgkin lymphoma spurred an influx of at least 20 monomethyl auristatin E (MMAE) antibody-drug…”
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Total Antibody Quantification for MMAE-Conjugated Antibody–Drug Conjugates: Impact of Assay Format and Reagents by Kozak, Katherine R, Tsai, Siao Ping, Fourie-O’Donohue, Aimee, dela Cruz Chuh, Josefa, Roth, Leslie, Cook, Ryan, Chan, Elton, Chan, Pamela, Darwish, Martine, Ohri, Rachana, Raab, Helga, Zhang, Crystal, Lin, Kedan, Wong, Wai Lee T

“…Antibody–drug conjugates (ADCs) are target-specific anticancer agents consisting of cytotoxic drugs covalently linked to a monoclonal antibody. The number of…”
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Structural transitions within human Rad51 nucleoprotein filaments by Robertson, Ragan B, Moses, Dana N, Kwon, YoungHo, Chan, Pamela, Chi, Peter, Klein, Hannah, Sung, Patrick, Greene, Eric C

“…Rad51 is a core component of the eukaryotic homologous recombination machinery and is responsible for key mechanistic steps during strand invasion. Higher…”
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Changes in cervical cancer incidence after three decades of screening US women less than 30 years old by Chan, Pamela G, Sung, Hai-Yen, Sawaya, George F

“…To examine incidence trends of invasive cervical carcinoma in US women less than 30 years old from 1973 to 1999 by histologic type. Incidence rates were…”
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The Use of Mobility Devices Among Institutionalized Older Adults by Clarke, Philippa, Chan, Pamela, Santaguida, P. Lina, Colantonio, Angela

“…Objectives: The purpose of this article is to examine the demographic, health, and social characteristics of mobility device users in long-term care settings…”
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The impact of discrimination against older people with dementia and its impact on student nurses professional socialisation by Chan, Pamela A., Chan, Tom

“…This paper aims to review the literature to identify persistent areas of concern in the care of the older person with dementia, and factors that may impact on…”
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Novel Foxo1-dependent transcriptional programs control Treg cell function by Ouyang, Weiming, Liao, Will, Luo, Chong T., Yin, Na, Huse, Morgan, Kim, Myoungjoo V., Peng, Min, Chan, Pamela, Ma, Qian, Mo, Yifan, Meijer, Dies, Zhao, Keji, Rudensky, Alexander Y., Atwal, Gurinder, Zhang, Michael Q., Li, Ming O.

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Predictive Modeling of Emergency Department Wait Times for Abdominal Pain Patients by Chan, Pamela Lee-Kar

“…Reducing emergency department (ED) wait times are a major priority for the Ontario Government. Overcrowded EDs, cumulative effects of the delays in hospital…”
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The Immunoglobulin Superfamily Receptome Defines Cancer-Relevant Networks Associated with Clinical Outcome by Verschueren, Erik, Husain, Bushra, Yuen, Kobe, Sun, Yi, Paduchuri, Sairupa, Senbabaoglu, Yasin, Lehoux, Isabelle, Arena, Tia A., Wilson, Blair, Lianoglou, Steve, Bakalarski, Corey, Franke, Yvonne, Chan, Pamela, Wong, Athena W., Gonzalez, Lino C., Mariathasan, Sanjeev, Turley, Shannon J., Lill, Jennie R., Martinez-Martin, Nadia

“…Cell surface receptors and their interactions play a central role in physiological and pathological signaling. Despite its clinical relevance, the…”
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High‐throughput identification of conditional MHCI ligands and scaled‐up production of conditional MHCI complexes by Darwish, Martine, Wichner, Sara, Li, Jenny, Chang, Jiun Chiun, Tam, Christine, Franke, Yvonne, Li, Hong, Chan, Pamela, Blanchette, Craig

“…Despite the need to monitor the impact of Cancer Immunotherapy (CI)/Immuno‐Oncology (IO) therapeutics on neoantigen‐specific T‐cell responses, very few…”
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Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid by Sadekar, Shraddha S., Bowen, Mayumi, Cai, Hao, Jamalian, Samira, Rafidi, Hanine, Shatz‐Binder, Whitney, Lafrance‐Vanasse, Julien, Chan, Pamela, Meilandt, William J., Oldendorp, Amy, Sreedhara, Alavattam, Daugherty, Ann, Crowell, Susan, Wildsmith, Kristin R., Atwal, Jasvinder, Fuji, Reina N., Horvath, Joshua

“…Delivery of biologics via cerebrospinal fluid (CSF) has demonstrated potential to access the tissues of the central nervous system (CNS) by circumventing the…”
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