Search Results - "Chan, Kyle W."

Endometrial regenerative cells: a novel stem cell population by Meng, Xiaolong, Ichim, Thomas E, Zhong, Jie, Rogers, Andrea, Yin, Zhenglian, Jackson, James, Wang, Hao, Ge, Wei, Bogin, Vladimir, Chan, Kyle W, Thébaud, Bernard, Riordan, Neil H

“…Angiogenesis is a critical component of the proliferative endometrial phase of the menstrual cycle. Thus, we hypothesized that a stem cell-like population…”
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The novel protein homeostatic modulator BTX306 is active in myeloma and overcomes bortezomib and lenalidomide resistance by Zou, Jianxuan, Jones, Richard J., Wang, Hua, Kuiatse, Isere, Shirazi, Fazal, Manasanch, Elisabet E., Lee, Hans C., Sullivan, Robert, Fung, Leah, Richard, Normand, Erdman, Paul, Torres, Eduardo, Hecht, David, Lam, Imelda, McElwee, Brooke, Chourasia, Aparajita H., Chan, Kyle W. H., Mercurio, Frank, Stirling, David I., Orlowski, Robert Z.

“…Small molecules targeting the cereblon-containing E3 ubiquitin ligase including thalidomide, lenalidomide, and pomalidomide modulate turnover of downstream…”
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Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells by VERHELLE, Dominique, CORRAL, Laura G, LOPEZ-GIRONA, Antonia, MUTTER, George W, BRADY, Helen A, CHAN, Kyle W. H, WONG, Kevin, MUELLER, Jessica H, MOUTOUH-DE PARSEVAL, Laure, JENSEN-PERGAKES, Kristen, SCHAFER, Peter H, CHEN, Roger, GLEZER, Emilia, FERGUSON, Gregory D

“…Clinical studies involving patients with myelodysplastic syndromes or multiple myeloma have shown the efficacy of lenalidomide by reducing and often…”
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A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure by Bradley, Jessica M, Spaletra, Pablo, Li, Zhen, Sharp, 3rd, Thomas E, Goodchild, Traci T, Corral, Laura G, Fung, Leah, Chan, Kyle W H, Sullivan, Robert W, Swindlehurst, Cathy A, Lefer, David J

“…Cardiac fibroblasts are critical mediators of fibrotic remodeling in the failing heart and transform into myofibroblasts in the presence of profibrotic factors…”
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Circulating endothelial progenitor cells: a new approach to anti-aging medicine? by Mikirova, Nina A, Jackson, James A, Hunninghake, Ron, Kenyon, Julian, Chan, Kyle W H, Swindlehurst, Cathy A, Minev, Boris, Patel, Amit N, Murphy, Michael P, Smith, Leonard, Alexandrescu, Doru T, Ichim, Thomas E, Riordan, Neil H

“…Endothelial dysfunction is associated with major causes of morbidity and mortality, as well as numerous age-related conditions. The possibility of preserving…”
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Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects by Mikirova, Nina A, Jackson, James A, Hunninghake, Ron, Kenyon, Julian, Chan, Kyle W H, Swindlehurst, Cathy A, Minev, Boris, Patel, Amit N, Murphy, Michael P, Smith, Leonard, Ramos, Famela, Ichim, Thomas E, Riordan, Neil H

“…The medical significance of circulating endothelial or hematopoietic progenitors is becoming increasing recognized. While therapeutic augmentation of…”
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Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors by Dulmovits, Brian M., Appiah-Kubi, Abena O., Papoin, Julien, Hale, John, He, Mingzhu, Al-Abed, Yousef, Didier, Sebastien, Gould, Michael, Husain-Krautter, Sehba, Singh, Sharon A., Chan, Kyle W.H., Vlachos, Adrianna, Allen, Steven L., Taylor, Naomi, Marambaud, Philippe, An, Xiuli, Gallagher, Patrick G., Mohandas, Narla, Lipton, Jeffrey M., Liu, Johnson M., Blanc, Lionel

“…Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin. Pomalidomide, a third-generation immunomodulatory drug, was…”
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Substituent Effects on the C−H Bond Dissociation Energy of Toluene. A Density Functional Study by Wu, Yun-Dong, Wong, Chui-Ling, Chan, Kyle W. K, Ji, Guo-Zhen, Jiang, Xi-Kui

“…The bond dissociation energies of the benzylic C−H bond of a series of 16 para-substituted toluene compounds (p-X-C6H4CH3) have been calculated with the…”
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Porphyrin Isomers:  Geometry, Tautomerism, Geometrical Isomerism, and Stability by Wu, Yun-Dong, Chan, Kyle W. K, Yip, Cong-Ping, Vogel, Emanuel, Plattner, Dietmar A, Houk, K. N

“…Density functional calculations have been carried out on free-base porphyrin (1) and its seven possible isomers (2−8) with an N4-metal coordination core. A…”
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Theoretical Study of Peptides Formed by Aminoxy Acids by Wu, Yun-Dong, Wang, De-Ping, Chan, Kyle W. K, Yang, Dan

“…Quantum mechanics methods have been applied to study the conformational features of peptides formed by aminoxy acids. Geometry and vibration frequencies were…”
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An Unusual Turn Structure in Peptides Containing α-Aminoxy Acids by Yang, Dan, Ng, Fei-Fu, Li, Zhan-Ji, Wu, Yun-Dong, Chan, Kyle W. K, Wang, De-Ping

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Abstract LB-211: Synergistic anti-metastatic effect of pembrolizumab in combination with a novel mTORC1 inhibitor/AMPK agonist in a CAM metastatic triple negative breast cancer model by Fung, Leah, Corral, Laura G., Sullivan, Robert W., Chan, Kyle W., Swindlehurst, Cathy A.

“…Triple negative breast cancer (TNBC) is highly aggressive and has higher rates of recurrence, resistance, and death than other breast cancers. Ten year…”
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Abstract 15417: Dual Ampk Activator/mtor Inhibitor Improves Metabolic Parameters in T2d Mice and Protects Cardiomyocytes Against Ischemic Injury by Kraskauskas, Donatas, Ni, Bin, Mauro, Adolfo G, Lau, Valerie, Kodali, Varun, Samidurai, Arun, Belka, Igor, Corral, Laura, Chan, Kyle W, Swindlehurst, Cathy A, Salloum, Fadi N, Das, Anindita

“…BackgroundType 2 diabetes (T2D) is a major metabolic disorder associated with increased morbidity and mortality, predominantly due to heart failure resulting…”
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Computational and Experimental Studies on the Thermolysis Mechanism of Zirconium and Hafnium Tetraalkyl Complexes. Difference between Titanium and Zirconium Complexes by Wu, Yun-Dong, Peng, Zhi-Hui, Chan, Kyle W. K, Liu, Xiaozhan, Tuinman, Albert A, Xue, Ziling

“…The first reaction step in the thermolysis of zirconium and hafnium tetraalkyl complexes has been studied with ab initio molecular orbital calculations in…”
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Abstract 17055: Novel Dual mTOR Inhibitor/AMPK Activator Mitigates Doxorubicin Cardiotoxicity and Potentiates Its Chemotherapeutic Efficacy Against Triple Negative Breast Cancer by Das, Anindita, Hovsepian, Sahak, Das, Sayantanee, Samidurai, Arun, Mauro, Adolfo G, Cain, Chad, Kraskauskas, Donatas, Corral, Laura, Fung, Leah, Sullivan, Robert, Chan, Kyle W, Swindlehurst, Cathy A, Salloum, Fadi N

“…BackgroundDoxorubicin (DOX) is a first-line anticancer drug for the treatment of triple negative breast cancer (TNBC). However, its dose-dependent delayed and…”
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Abstract 3341: Targeting CXCR4 via the small molecule inhibitor NMX1 as a therapeutic strategy to treat high-risk malignancies by Sipila, Patrick, Tran, Son, Zhang, Chunfen, Corral, Laura G., Chan, Kyle W., Swindlehurst, Cathy A., Narendran, Aru

“…Introduction: Cytokines are secreted by various cells of the immune system, endothelium, and stroma that play a critical role in cell survival. The activation…”
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Transition Structures of Methane Elimination in Pentamethylniobium and Pentamethyltantalum by Wu, Yun-Dong, Chan, Kyle W. K, Xue, Ziling

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Abstract 1963: Targeting hematological malignancies with two functionally and mechanistically distinct classes of cereblon mediated protein homeostatic modulators by Chourasia, Aparajita Hoskote, Fung, Leah, Pasis, Angela, McElwee, Brooke, Schoolmeesters, Angela, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle W., Mercurio, Frank, Stirling, David I.

“…BioTheryX's novel and unique Protein Homeostatic Modulators (PHMsTM) are small molecule “molecular glues” that promote ubiquitination of substrate proteins by…”
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Abstract 14309: A Novel Fibroblast Activation Inhibitor, NM922, Attenuates Maladaptive Fibrotic Remodeling to Preserve Cardiac Function Following the Onset of Heart Failure by Bradley, Jessica M, Ziblich, Craig M, Islam, Kazi N, Rushing, Amanda M, Polhemus, David J, Corral, Laura G, Sullivan, Robert W, Fung, Leah, Chan, Kyle W, Swindlehurst, Cathy A, Lefer, David J

“…BackgroundCardiac fibroblasts are critical mediators of fibrotic remodeling in the failing heart. These maladaptive structural changes can worsen cardiac…”
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Abstract 4527: Oral multi-pathway inhibitors for the treatment of triple negative breast cancer by Swindlehurst, Cathy A., Chan, Kyle W. H., Fung, Leah, Sullivan, Robert W., Ottilie, Sabine, Slepenkov, Sergey V., Huang, Shile, Rhoads, Robert E.

“…Triple negative breast cancer (TNBC: estrogen and progesterone receptor and Her2/Neu negative) is a high grade malignancy that is more aggressive with a higher…”
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