Search Results - "Chan, Juliana M"

Microfluidic Models of Vascular Functions by Wong, Keith H.K, Chan, Juliana M, Kamm, Roger D, Tien, Joe

“…In vitro studies of vascular physiology have traditionally relied on cultures of endothelial cells, smooth muscle cells, and pericytes grown on…”
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Lipid-coated polymeric nanoparticles for cancer drug delivery by Krishnamurthy, Sangeetha, Vaiyapuri, Rajendran, Zhang, Liangfang, Chan, Juliana M

“…Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but…”
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PLGA–lecithin–PEG core–shell nanoparticles for controlled drug delivery by Chan, Juliana M, Zhang, Liangfang, Yuet, Kai P, Liao, Grace, Rhee, June-Wha, Langer, Robert, Farokhzad, Omid C

“…Abstract Current approaches to encapsulate and deliver therapeutic compounds have focused on developing liposomal and biodegradable polymeric nanoparticles…”
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Engineering of in vitro 3D capillary beds by self-directed angiogenic sprouting by Chan, Juliana M, Zervantonakis, Ioannis K, Rimchala, Tharathorn, Polacheck, William J, Whisler, Jordan, Kamm, Roger D

“…In recent years, microfluidic systems have been used to study fundamental aspects of angiogenesis through the patterning of single-layered, linear or geometric…”
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Spatiotemporal controlled delivery of nanoparticles to injured vasculature by Chan, Juliana M, Zhang, Liangfang, Tong, Rong, Ghosh, Debuyati, Gao, Weiwei, Liao, Grace, Yuet, Kai P, Gray, David, Rhee, June-Wha, Cheng, Jianjun, Golomb, Gershon, Libby, Peter, Langer, Robert, Farokhzad, Omid C

“…There are a number of challenges associated with designing nanoparticles for medical applications. We define two challenges here: (i) conventional targeting…”
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Polymeric Materials for Gene Delivery and DNA Vaccination by Nguyen, David N., Green, Jordan J., Chan, Juliana M., Langer, Robert, Anderson, Daniel G.

“…Gene delivery holds great potential for the treatment of many different diseases. Vaccination with DNA holds particular promise, and may provide a solution to…”
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In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid—polymeric nanoparticles by Chan, Juliana M., Rhee, June-Wha, Drum, Chester L., Bronson, Roderick T., Golomb, Gershon, Langer, Robert, Farokhzad, Omid C.

“…Following recent successes with percutaneous coronary intervention (PCI) for treating coronary artery disease (CAD), many challenges remain. In particular,…”
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Thermostable exoshells fold and stabilize recombinant proteins by Deshpande, Siddharth, Masurkar, Nihar D., Girish, Vallerinteavide Mavelli, Desai, Malan, Chakraborty, Goutam, Chan, Juliana M., Drum, Chester L.

“…The expression and stabilization of recombinant proteins is fundamental to basic and applied biology. Here we have engineered a thermostable protein…”
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Biofunctionalized targeted nanoparticles for therapeutic applications by Wang, Andrew Z, Gu, Frank, Zhang, Liangfang, Chan, Juliana M, Radovic-Moreno, Aleksander, Shaikh, Mariam R, Farokhzad, Omid C

“…The development of nanoparticles for the delivery of therapeutic agents has introduced new opportunities for the improvement of medical treatment. Recent…”
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pH-Responsive Nanoparticles for Drug Delivery by Gao, Weiwei, Chan, Juliana M, Farokhzad, Omid C

“…First-generation nanoparticles (NPs) have been clinically translated as pharmaceutical drug delivery carriers for their ability to improve on drug…”
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Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform by Zhang, Liangfang, Chan, Juliana M, Gu, Frank X, Rhee, June-Wha, Wang, Andrew Z, Radovic-Moreno, Aleksandar F, Alexis, Frank, Langer, Robert, Farokhzad, Omid C

“…We report the engineering of a novel lipid−polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and…”
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Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection by Xiao, Zeyu, Levy-Nissenbaum, Etgar, Alexis, Frank, Lupták, Andrej, Teply, Benjamin A, Chan, Juliana M, Shi, Jinjun, Digga, Elise, Cheng, Judy, Langer, Robert, Farokhzad, Omid C

“…One of the major challenges in the development of targeted nanoparticles (NPs) for cancer therapy is to discover targeting ligands that allow for differential…”
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Polymeric nanoparticles for drug delivery by Chan, Juliana M, Valencia, Pedro M, Zhang, Liangfang, Langer, Robert, Farokhzad, Omid C

“…The use of biodegradable polymeric nanoparticles (NPs) for controlled drug delivery has shown significant therapeutic potential. Concurrently, targeted…”
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Surface protein engineering increases the circulation time of a cell membrane-based nanotherapeutic by Krishnamurthy, Sangeetha, Muthukumaran, Padmalosini, Jayakumar, Muthu Kumara Gnanasammandhan, Lisse, Domenik, Masurkar, Nihar D., Xu, Chenjie, Chan, Juliana M., Drum, Chester L.

“…Mammalian cell membranes are often incompatible with chemical modifications typically used to increase circulation half-life. Using cellular nanoghosts as a…”
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Examining public acquisition of science knowledge from social media in Singapore: an extension of the cognitive mediation model by Ho, Shirley S., Yang, Xiaodong, Thanwarani, Amber, Chan, Juliana M.

“…This study extends the cognitive mediation model (CMM) by examining the role of social media in cultivating public science knowledge. A sample of 901…”
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Evidence for allosteric effects on p53 oligomerization induced by phosphorylation by Muller, Petr, Chan, Juliana M., Simoncik, Oliver, Fojta, Miroslav, Lane, David P., Hupp, Ted, Vojtesek, Borivoj

“…p53 is a tetrameric protein with a thermodynamically unstable deoxyribonucleic acid (DNA)‐binding domain flanked by intrinsically disordered regulatory domains…”
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Microengineering in cardiovascular research: new developments and translational applications by Chan, Juliana M, Wong, Keith H K, Richards, Arthur Mark, Drum, Chester L

“…Microfluidic, cellular co-cultures that approximate macro-scale biology are important tools for refining the in vitro study of organ-level function and…”
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Perspectives in micro- and nanotechnology for biomedical applications: edited by Juliana M. Chan, Chenjie Xu, Nanyang Technological University, Singapore by Chan, Juliana M, Xu, Chenjie

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Rationale and Design of the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) Trial by Holman, Rury R., FRCP, FMedSci, Bethel, M. Angelyn, MD, George, Jyothis, MRCPE, MRCP (UK), PhD, Sourij, Harald, MD, Doran, Zoë, RN, Keenan, Joanne, BA, Khurmi, Nardev S., MD, Mentz, Robert J., MD, Oulhaj, Abderrahim, PhD, Buse, John B., MD, PhD, Chan, Juliana C., MD, Iqbal, Nayyar, MD, Kundu, Sudeep, PhD, Maggioni, Aldo P., MD, Marso, Steven P., MD, Öhman, Peter, MD, PhD, Pencina, Michael J., PhD, Poulter, Neil, FMedSci, Porter, Lisa E., MD, Ramachandran, Ambady, MD, Zinman, Bernard, MD, Hernandez, Adrian F., MD, MHS

“…Abstract Exenatide once-weekly is an extended release formulation of exenatide, a glucagon-like peptide (GLP)-1 receptor agonist, which can improve glycemic…”
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Premature Mortality and Comorbidities in Young-onset Diabetes: A 7-Year Prospective Analysis by Chan, Juliana C.N., MD, Lau, Eric S.H., MPhil, Luk, Andrea O.Y., MRCP, Cheung, Kitty K.T., MRCP, Kong, Alice P.S., MD, Yu, Linda W.L., MRCP, Choi, Kai-Chow, PhD, Chow, Francis C.C., FRACP, Ozaki, Risa, MRCP, Brown, Nicola, MSc, Yang, Xilin, PhD, Bennett, Peter H., MD, Ma, Ronald C.W., MD, So, Wing-Yee, MD

“…Abstract Background There is an increasing prevalence of young-onset diabetes, especially in developing areas. We compared the clinical outcomes and predictors…”
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