Search Results - "Chan, Jeniffer"

Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain by Hirsch-Reinshagen, Veronica, Zhou, Steven, Burgess, Braydon L., Bernier, Lise, McIsaac, Sean A., Chan, Jeniffer Y., Tansley, Gavin H., Cohn, Jeffrey S., Hayden, Michael R., Wellington, Cheryl L.

“…ABCA1 is a cholesterol transporter that is widely expressed throughout the body. Outside the central nervous system (CNS), ABCA1 functions in the biogenesis of…”
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Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus by Stukas, Sophie, Robert, Jerome, Lee, Michael, Kulic, Iva, Carr, Michael, Tourigny, Katherine, Fan, Jianjia, Namjoshi, Dhananjay, Lemke, Kalistyne, DeValle, Nicole, Chan, Jeniffer, Wilson, Tammy, Wilkinson, Anna, Chapanian, Rafi, Kizhakkedathu, Jayachandran N., Cirrito, John R., Oda, Michael N., Wellington, Cheryl L.

“…Background Brain lipoprotein metabolism is dependent on lipoprotein particles that resemble plasma high‐density lipoproteins but that contain apolipoprotein…”
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Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer’s disease mouse models with abundant Aβ in plasma by Burgess, Braydon L., McIsaac, Sean A., Naus, Kathryn E., Chan, Jeniffer Y., Tansley, Gavin H.K., Yang, Jing, Miao, Fudan, Ross, Colin J.D., van Eck, Miranda, Hayden, Michael R., van Nostrand, William, St. George-Hyslop, Peter, Westaway, David, Wellington, Cheryl L.

“…Dietary or pharmacological manipulation of plasma lipids markedly influences amyloid deposition in animal models of Alzheimer’s Disease (AD). However, it is…”
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Hormonal modulators of glial ABCA1 and apoE levels[S] by Fan, Jianjia, Shimizu, Yoko, Chan, Jeniffer, Wilkinson, Anna, Ito, Ayaka, Tontonoz, Peter, Dullaghan, Edie, Galea, LiisaA.M., Pfeifer, Tom, Wellington, Cheryl L.

“…Apolipoprotein E (apoE) is the major lipid carrier in the central nervous system. As apoE plays a major role in the pathogenesis of Alzheimer disease (AD) and…”
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ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo by Burgess, Braydon L., Parkinson, Pamela F., Racke, Margaret M., Hirsch-Reinshagen, Veronica, Fan, Jianjia, Wong, Charmaine, Stukas, Sophie, Theroux, Louise, Chan, Jeniffer Y., Donkin, James, Wilkinson, Anna, Balik, Danielle, Christie, Brian, Poirier, Judes, Lütjohann, Dieter, DeMattos, Ronald B., Wellington, Cheryl L.

“…Cholesterol homeostasis is of emerging therapeutic importance for Alzheimer's disease (AD). Agonists of liver-X-receptors (LXRs) stimulate several genes that…”
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LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice[S] by Stukas, Sophie, Freeman, Lita, Lee, Michael, Wilkinson, Anna, Ossoli, Alice, Vaisman, Boris, Demosky, Stephen, Chan, Jeniffer, Hirsch-Reinshagen, Veronica, Remaley, Alan T., Wellington, Cheryl L.

“…A key step in plasma HDL maturation from discoidal to spherical particles is the esterification of cholesterol to cholesteryl ester, which is catalyzed by…”
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The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of β-amyloid precursor protein by Tansley, Gavin H., Burgess, Braydon L., Bryan, Matt T., Yuan, Su, Veronica, Hirsch-Reinshagen, Jonathan, Pearce, Chan, Jeniffer Y., Anna, Wilkinson, Jeanette, Evans, Naus, Kathryn E., Sean, McIsaac, Kelley, Bromley, Weihong, Song, Hsui-Chiung, Yang, Nan, Wang, DeMattos, Ronald B., Wellington, Cheryl L.

“…Although intracellular cholesterol levels are known to influence the proteolysis of β-amyloid precursor protein (APP), the effect of specific genes that…”
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The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility by Selva, David M., Hirsch-Reinshagen, Veronica, Burgess, Braydon, Zhou, Steven, Chan, Jeniffer, McIsaac, Sean, Hayden, Michael R., Hammond, Geoffrey L., Vogl, A. Wayne, Wellington, Cheryl L.

“…The liver X receptor/retinoid X receptor (LXR/RXR)-regulated gene ABCA1 effluxes cellular cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is…”
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ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice by Donkin, James J., Stukas, Sophie, Hirsch-Reinshagen, Veronica, Namjoshi, Dhananjay, Wilkinson, Anna, May, Sharon, Chan, Jeniffer, Fan, Jianjia, Collins, Jon, Wellington, Cheryl L.

“…The cholesterol transpoter ATP-binding cassette transporter A1 (ABCA1) moves lipids onto apolipoproteins including apolipoprotein E (apoE), which is the major…”
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The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1 by Stukas, Sophie, May, Sharon, Wilkinson, Anna, Chan, Jeniffer, Donkin, James, Wellington, Cheryl L.

“…Lipoprotein metabolism in the central nervous system (CNS) is based on high-density lipoprotein-like particles that use apoE as their predominant…”
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Overexpression of Human ABCG1 Does Not Affect Atherosclerosis in Fat-Fed ApoE-Deficient Mice by Burgess, Braydon, Naus, Kathryn, Chan, Jeniffer, Hirsch-Reinshagen, Veronica, Tansley, Gavin, Matzke, Lisa, Chan, Benny, Wilkinson, Anna, Fan, Jianjia, Donkin, James, Balik, Danielle, Tanaka, Tracie, Ou, George, Dyer, Roger, Innis, Sheila, McManus, Bruce, Lütjohann, Dieter, Wellington, Cheryl

“…OBJECTIVE—The purpose of this study was to evaluate the effects of whole body overexpression of human ABCG1 on atherosclerosis in apoE mice. METHODS AND…”
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P4‐218: The liver X receptor agonist GW3965 improves cognitive deficits, reduces beta‐amyloid elevation and suppresses neuronal damage following mild repetitive closed head injury in mice by Namjoshi, Dhananjay, Martin, Georgina, Donkin, James, Stukas, Sophie, Wilkinson, Anna, Fan, Jianjia, Carr, Mike, Chan, Jeniffer, Wellington, Cheryl

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The liver X receptor agonist GW3965 improves cognitive deficits, reduces beta-amyloid elevation and suppresses neuronal damage following mild repetitive closed head injury in mice by Namjoshi, Dhananjay, Martin, Georgina, Donkin, James, Stukas, Sophie, Wilkinson, Anna, Fan, Jianjia, Carr, Mike, Chan, Jeniffer, Wellington, Cheryl

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P3‐290: ABCA1 is required for the beneficial effects of the liver‐X‐receptor agonist GW3965 on biochemical and cognitive outcomes in the APP/PS1 mouse model of Alzheimer's disease by Donkin, James, Stukas, Sophie, Namjoshi, Dhananjay, Hirsch‐Reinshagen, Veronica, Chan, Jeniffer, Wilkinson, Anna, Collins, Jon, Wellington, Cheryl L.

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ABCA1 is required for the beneficial effects of the liver-X-receptor agonist GW3965 on biochemical and cognitive outcomes in the APP/PS1 mouse model of Alzheimer's disease by Donkin, James, Stukas, Sophie, Namjoshi, Dhananjay, Hirsch-Reinshagen, Veronica, Chan, Jeniffer, Wilkinson, Anna, Collins, Jon, Wellington, Cheryl L

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O1-03-07 ABCA1 modulates APOE levels in brain and plasma by Hirsch-Reinshagen, Veronica, Zhou, Steven, Chan, Jeniffer, McIsaac, Sean, Cohn, Jeffrey, Hayden, Michael, Wellington, Cheryl

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P1-053: Alzheimer’s disease neuropathology is not mitigated by the physiological expression of human ABCA1 in APP/PS1 mice by Hirsch-Reinshagen, Veronica, Chan, Jeniffer Y., McIsaac, Sean A., Naus, Kathryn E., Maia, Luis F., Burgess, Braydon L., Singaraja, Roshni R., Hayden, Michael R., Wellington, Cheryl L.

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P2-026: The cholesterol transporter ABCG1 modulates the proteolytic processing of amyloid precursor protein by Tansley, Gavin, Burgess, Braydon L., Bryan, Matt, Su, Yuan, Chan, Jeniffer Y., Naus, Kathryn E., McIsaac, Sean, Hirsch-Reinshagen, Veronica, Yang, Hsui-Chiung, DeMattos, Ronald B., Wellington, Cheryl L.

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