Search Results - "Chan, Hua‐Chen"

Role of Low‐Density Lipoprotein in Early Vascular Aging Associated With Systemic Lupus Erythematosus by Chan, Hua‐Chen, Chan, Hsiu‐Chuan, Liang, Chan‐Jung, Lee, Hsiang‐Chun, Su, Hung, Lee, An‐Sheng, Shiea, Jentaie, Tsai, Wen‐Chan, Ou, Tsan‐Teng, Wu, Cheng‐Chin, Chu, Chih‐Sheng, Dixon, Richard A., Ke, Liang‐Yin, Yen, Jeng‐Hsien, Chen, Chu‐Huang

“…Objective Patients with systemic lupus erythematosus (SLE) often have atherosclerotic complications at a young age but normal low‐density lipoprotein (LDL)…”
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Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects by Kakino, Akemi, Fujita, Yoshiko, Ke, Liang-Yin, Chan, Hua-Chen, Tsai, Ming-Hsien, Dai, Chia-Yen, Chen, Chu-Huang, Sawamura, Tatsuya

“…Adiponectin, an adipocyte-derived protein, has antiatherogenic and antidiabetic effects, but how it confers the atherogenic effects is not well known. To study…”
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Untargeted Lipidomic Profiling Reveals Lysophosphatidylcholine and Ceramide as Atherosclerotic Risk Factors in apolipoprotein E Knockout Mice by Law, Shi-Hui, Chan, Hua-Chen, Ke, Guan-Ming, Kamatam, Swetha, Marathe, Gopal Kedihithlu, Ponnusamy, Vinoth Kumar, Ke, Liang-Yin

“…Despite the availability and use of numerous cholesterol-lowering drugs, atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality…”
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Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo by Wang, Yu‐Chen, Lee, An‐Sheng, Lu, Long‐Sheng, Ke, Liang‐Yin, Chen, Wei‐Yu, Dong, Jian‐Wen, Lu, Jonathan, Chen, Zhenping, Chu, Chih‐Sheng, Chan, Hua‐Chen, Kuzan, Taha Y., Tsai, Ming‐Hsien, Hsu, Wen‐Li, Dixon, Richard A. F., Sawamura, Tatsuya, Chang, Kuan‐Cheng, Chen, Chu‐Huang

“…Summary Dysregulation of plasma lipids is associated with age‐related cardiovascular diseases. L5, the most electronegative subfraction of chromatographically…”
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Increased APOE glycosylation plays a key role in the atherogenicity of L5 low‐density lipoprotein by Ke, Liang‐Yin, Chan, Hua‐Chen, Chen, Chih‐Chieh, Chang, Chuan‐Fa, Lu, Po‐Liang, Chu, Chih‐Sheng, Lai, Wen‐Ter, Shin, Shyi‐Jang, Liu, Fu‐Tong, Chen, Chu‐Huang

“…Low‐density lipoprotein (LDL) is heterogeneous, composed of particles with variable atherogenicity. Electronegative L5 LDL exhibits atherogenic properties in…”
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Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation by Shen, Ming-Yi, Chen, Fang-Yu, Hsu, Jing-Fang, Fu, Ru-Huei, Chang, Chia-Ming, Chang, Chiz-Tzung, Liu, Chung-Hsiang, Wu, Jia-Rong, Lee, An-Sheng, Chan, Hua-Chen, Sheu, Joen-Rong, Lin, Shinn-Zong, Shyu, Woei-Cherng, Sawamura, Tatsuya, Chang, Kuan-Cheng, Hsu, Chung Y., Chen, Chu-Huang

“…L5, the most electronegative and atherogenic subfraction of low-density lipoprotein (LDL), induces platelet activation. We hypothesized that plasma L5 levels…”
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A novel CD209 polymorphism is associated with rheumatoid arthritis patients in Taiwan by Chan, Hua‐Chen, Wang, Shu‐Chen, Lin, Chia‐Hui, Lin, Yuan‐Zhao, Li, Ruei‐Nian, Yen, Jeng‐Hsien

“…Single nucleotide polymorphisms (SNPs) in the promoter region of CD209 (cluster of differentiation 209) may influence expression levels, and higher expression…”
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Range of L5 LDL levels in healthy adults and L5’s predictive power in patients with hyperlipidemia or coronary artery disease by Chu, Chih-Sheng, Chan, Hua-Chen, Tsai, Ming-Hsien, Stancel, Nicole, Lee, Hsiang-Chun, Cheng, Kai-Hung, Tung, Yi-Ching, Chan, Hsiu-Chuan, Wang, Chung-Ya, Shin, Shyi-Jang, Lai, Wen-Ter, Yang, Chao-Yuh, Dixon, Richard A., Chen, Chu-Huang, Ke, Liang-Yin

“…Electronegative L5 low-density lipoprotein (LDL) level may be a useful biomarker for predicting cardiovascular disease. We determined the range of plasma L5…”
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Electronegative Low-Density Lipoprotein L5 Induces Adipose Tissue Inflammation Associated With Metabolic Syndrome by Ke, Liang-Yin, Chan, Hua-Chen, Chan, Hsiu-Chuan, Kalu, Franklin Chikodi Udo, Lee, Hsiang-Chun, Lin, I-Ling, Jhuo, Shih-Jie, Lai, Wen-Ter, Tsao, Chen-Rong, Sawamura, Tatsuya, Dixon, Richard A, Chen, Chu-Huang, Chu, Chih-Sheng, Shin, Shyi-Jang

“…Abstract Context Electronegative low-density lipoprotein (LDL) L5 is a naturally occurring, atherogenic entity found at elevated levels in the plasma of…”
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Electronegative low‐density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade by Chen, Chao‐Hung, Ke, Liang‐Yin, Chan, Hua‐Chen, Chu, Chih‐Sheng, Lee, An‐Sheng, Lin, Kun‐Der, Lee, Mei‐Yueh, Hsiao, Pi‐Jung, Chen, Chu‐Huang, Shin, Shyi‐Jang

“…Aims/Introduction Electronegative low‐density lipoprotein (L5) is the most atherogenic fraction of low‐density lipoprotein and is elevated in people with…”
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Lower HDAC6 mRNA expression and promoter hypomethylation are associated with RA susceptibility by Fang, Tzu-Jung, Lin, Chia-Hui, Lin, Yuan-Zhao, Chiu, Min-HSi, Li, Ruei-Nian, Chan, Hua-Chen, Yeh, Yao-Tsung, Yen, Jeng-Hsien

“…Recent studies showed that Histone deacetylases 6 (HDAC6) inhibitors could improve arthritis in rheumatoid arthritis (RA) rodent models, whereas lower HDAC6…”
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Molecular and Cellular Mechanisms of Electronegative Lipoproteins in Cardiovascular Diseases by Ke, Liang-Yin, Law, Shi Hui, Mishra, Vineet Kumar, Parveen, Farzana, Chan, Hua-Chen, Lu, Ye-Hsu, Chu, Chih-Sheng

“…Dysregulation of glucose and lipid metabolism increases plasma levels of lipoproteins and triglycerides, resulting in vascular endothelial damage. Remarkably,…”
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Enhanced Sphingomyelinase Activity Contributes to the Apoptotic Capacity of Electronegative Low-Density Lipoprotein by Ke, Liang-Yin, Chan, Hua-Chen, Chen, Chih-Chieh, Lu, Jonathan, Marathe, Gopal K, Chu, Chih-Sheng, Chan, Hsiu-Chuan, Wang, Chung-Ya, Tung, Yi-Ching, McIntyre, Thomas M, Yen, Jeng-Hsien, Chen, Chu-Huang

“…Sphingomyelinase (SMase) catalyzes the degradation of sphingomyelin to ceramide. In patients with metabolic syndrome or diabetes, circulating plasma ceramide…”
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Electronegative low density lipoprotein induces renal apoptosis and fibrosis: STRA6 signaling involved[S] by Chen, Chao-Hung, Ke, Liang-Yin, Chan, Hua-Chen, Lee, An-Sheng, Lin, Kun-Der, Chu, Chih-Sheng, Lee, Mei-Yueh, Hsiao, Pi-Jung, Hsu, Chin, Chen, Chu-Huang, Shin, Shyi-Jang

“…Dyslipidemia has been proven to capably develop and aggravate chronic kidney disease. We also report that electronegative LDL (L5) is the most atherogenic LDL…”
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Human electronegative low-density lipoprotein modulates cardiac repolarization via LOX-1-mediated alteration of sarcolemmal ion channels by Lee, An-Sheng, Xi, Yutao, Lai, Chin-Hu, Chen, Wei-Yu, Peng, Hsien-Yu, Chan, Hua-Chen, Chen, Chu-Huang, Chang, Kuan-Cheng

“…Dyslipidemia is associated with greater risk of ventricular tachyarrhythmias in patients with cardiovascular diseases. We aimed to examine whether the most…”
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Lysophosphatidylcholine Impairs the Mitochondria Homeostasis Leading to Trophoblast Dysfunction in Gestational Diabetes Mellitus by Hung, Shao-Chi, Chan, Te-Fu, Chan, Hsiu-Chuan, Wu, Chia-Ying, Chan, Mei-Lin, Jhuang, Jie-Yang, Tan, Ji-Qin, Mei, Jia-Bin, Law, Shi-Hui, Ponnusamy, Vinoth Kumar, Chan, Hua-Chen, Ke, Liang-Yin

“…Gestational diabetes mellitus (GDM) is a common pregnancy disorder associated with an increased risk of pre-eclampsia and macrosomia. Recent research has shown…”
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Efficiency comparison of PGBR extract and γ‐oryzanol in antioxidative stress and anti‐inflammatory properties against metabolic syndrome by Lin, Hui‐Li, Lin, Shih‐Hsiung, Shen, Kuo‐Ping, Chan, Hua‐Chen, Tseng, Yu‐Hsiu, Yen, Hsueh‐Wei, Law, Shi‐Hui, Ke, Liang‐Yin

“…This research aims to delineate the anti‐inflammatory effect of pregerminated brown rice extract (PE) and γ‐oryzanol on improving metabolic features of…”
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Clinical Significance of Electronegative Low-Density Lipoprotein Cholesterol in Atherothrombosis by Chu, Chih-Sheng, Law, Shi Hui, Lenzen, David, Tan, Yong-Hong, Weng, Shih-Feng, Ito, Etsuro, Wu, Jung-Chou, Chen, Chu-Huang, Chan, Hua-Chen, Ke, Liang-Yin

“…Despite the numerous risk factors for atherosclerotic cardiovascular diseases (ASCVD), cumulative evidence shows that electronegative low-density lipoprotein…”
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An Increased Plasma Level of ApoCIII-Rich Electronegative High-Density Lipoprotein May Contribute to Cognitive Impairment in Alzheimer's Disease by Chan, Hua-Chen, Ke, Liang-Yin, Lu, Hsiao-Ting, Weng, Shih-Feng, Chan, Hsiu-Chuan, Law, Shi-Hui, Lin, I-Ling, Chang, Chuan-Fa, Lu, Ye-Hsu, Chen, Chu-Huang, Chu, Chih-Sheng

“…High-density lipoprotein (HDL) plays a vital role in lipid metabolism and anti-inflammatory activities; a dysfunctional HDL impairs cholesterol efflux…”
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Chemical composition-oriented receptor selectivity of L5, a naturally occurring atherogenic low-density lipoprotein by Ke, Liang-Yin, Engler, David A., Lu, Jonathan, Matsunami, Risë K., Chan, Hua-Chen, Wang, Guei-Jane, Yang, Chao-Yuh, Chang, Jan-Gowth, Chen, Chu-Huang

“…Anion-exchange chromatography resolves human plasma low-density lipoprotein (LDL) into 5 subfractions, with increasing negative surface charge in the direction…”
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