Search Results - "Chan, H. T. Henry"

Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification by Brewitz, Lennart, Henry Chan, H T, Lukacik, Petra, Strain-Damerell, Claire, Walsh, Martin A, Duarte, Fernanda, Schofield, Christopher J

“…The SARS-CoV-2 papain-like protease (PL ) and main protease (M ) are nucleophilic cysteine enzymes that catalyze hydrolysis of the viral polyproteins pp1a/1ab…”
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Discovery of SARS-CoV-2 M pro peptide inhibitors from modelling substrate and ligand binding by Chan, H T Henry, Moesser, Marc A, Walters, Rebecca K, Malla, Tika R, Twidale, Rebecca M, John, Tobias, Deeks, Helen M, Johnston-Wood, Tristan, Mikhailov, Victor, Sessions, Richard B, Dawson, William, Salah, Eidarus, Lukacik, Petra, Strain-Damerell, Claire, Owen, C David, Nakajima, Takahito, Świderek, Katarzyna, Lodola, Alessio, Moliner, Vicent, Glowacki, David R, Spencer, James, Walsh, Martin A, Schofield, Christopher J, Genovese, Luigi, Shoemark, Deborah K, Mulholland, Adrian J, Duarte, Fernanda, Morris, Garrett M

“…The main protease (M ) of SARS-CoV-2 is central to viral maturation and is a promising drug target, but little is known about structural aspects of how it…”
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Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M pro inhibitors by Malla, Tika R, Tumber, Anthony, John, Tobias, Brewitz, Lennart, Strain-Damerell, Claire, Owen, C David, Lukacik, Petra, Chan, H T Henry, Maheswaran, Pratheesh, Salah, Eidarus, Duarte, Fernanda, Yang, Haitao, Rao, Zihe, Walsh, Martin A, Schofield, Christopher J

“…The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a…”
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Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism by Aertker, Kristina M.J., Chan, H.T. Henry, Lohans, Christopher T., Schofield, Christopher J.

“…An important mechanism of resistance to β-lactam antibiotics is via their β-lactamase–catalyzed hydrolysis. Recent work has shown that, in addition to the…”
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Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants by Lohans, Christopher T., Chan, H. T. Henry, Malla, Tika R., Kumar, Kiran, Kamps, Jos J. A. G., McArdle, Darius J. B., van Groesen, Emma, de Munnik, Mariska, Tooke, Catherine L., Spencer, James, Paton, Robert S., Brem, Jürgen, Schofield, Christopher J.

“…Enzymes often use nucleophilic serine, threonine, and cysteine residues to achieve the same type of reaction; the underlying reasons for this are not…”
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Dynamical Nonequilibrium Molecular Dynamics Simulations Identify Allosteric Sites and Positions Associated with Drug Resistance in the SARS-CoV‑2 Main Protease by Chan, H. T. Henry, Oliveira, A. Sofia F., Schofield, Christopher J., Mulholland, Adrian J., Duarte, Fernanda

“…The SARS-CoV-2 main protease (Mpro) plays an essential role in the coronavirus lifecycle by catalyzing hydrolysis of the viral polyproteins at specific sites…”
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Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2′ proline of the viral polyprotein by Chan, H. T. Henry, Brewitz, Lennart, Lukacik, Petra, Strain-Damerell, Claire, Walsh, Martin A, Schofield, Christopher J, Duarte, Fernanda

“…The SARS-CoV-2 papain-like protease (PL pro ) is an antiviral drug target that catalyzes the hydrolysis of the viral polyproteins pp1a/1ab, so releasing the…”
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Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding by Chan, H T Henry, Moesser, Marc A, Walters, Rebecca K, Malla, Tika R, Twidale, Rebecca M, Tobias, John, Deeks, Helen M, Johnston-Wood, Tristan, Mikhailov, Victor, Sessions, Richard B, Dawson, William, Eidarus Salah, Lukacik, Petra, Strain-Damerell, Claire, Owen, C David, Nakajima, Takahito, Świderek, Katarzyna, Lodola, Alessio, Moliner, Vicent, Glowacki, David R, Spencer, James, Walsh, Martin A, Schofield, Christopher J, Genovese, Luigi, Shoemark, Deborah K, Mulholland, Adrian J, Duarte, Fernanda, Morris, Garrett M

“…The main protease (Mpro) of SARS-CoV-2 is central to viral maturation and is a promising drug target, but little is known about structural aspects of how it…”
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Voltammetry using multiple cycles: Porous electrodes by Chan, Henry T.H., Kätelhön, Enno, Compton, Richard G.

“…Simulations are reported for the cyclic voltammetry of both electrochemically reversible and irreversible one-electron processes at porous electrodes where the…”
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Voltammetry at electrodes decorated with an insulating porous film: Understanding the effects of adsorption by Chan, Henry T.H., Kätelhön, Enno, Compton, Richard G.

“…Recent literature has evinced a keen interest in porous electrodes. Numerous applications have been discussed and some aspects of the voltammetry investigated,…”
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Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants by Lohans, Christopher T., Chan, H. T. Henry, Malla, Tika R., Kumar, Kiran, Kamps, Jos J. A. G., McArdle, Darius J. B., van Groesen, Emma, de Munnik, Mariska, Tooke, Catherine L., Spencer, James, Paton, Robert S., Brem, Jürgen, Schofield, Christopher J.

“…Enzymes often use nucleophilic serine, threonine, and cysteine residues to achieve the same type of reaction; the underlying reasons for this are not…”
Get full text

Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism by Aertker, Kristina M J, Chan, H T Henry, Lohans, Christopher T, Schofield, Christopher J

“…An important mechanism of resistance to β-lactam antibiotics is via their β-lactamase-catalyzed hydrolysis. Recent work has shown that, in addition to the…”
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Discovery of SARS-CoV-2 M peptide inhibitors from modelling substrate and ligand binding by Chan, H. T. Henry, Moesser, Marc A, Walters, Rebecca K, Malla, Tika R, Twidale, Rebecca M, John, Tobias, Deeks, Helen M, Johnston-Wood, Tristan, Mikhailov, Victor, Sessions, Richard B, Dawson, William, Salah, Eidarus, Lukacik, Petra, Strain-Damerell, Claire, Owen, C. David, Nakajima, Takahito, widerek, Katarzyna, Lodola, Alessio, Moliner, Vicent, Glowacki, David R, Spencer, James, Walsh, Martin A, Schofield, Christopher J, Genovese, Luigi, Shoemark, Deborah K, Mulholland, Adrian J, Duarte, Fernanda, Morris, Garrett M

“…The main protease (M pro ) of SARS-CoV-2 is central to viral maturation and is a promising drug target, but little is known about structural aspects of how it…”
Get full text